A role for WRN in telomere-based DNA damage responses

scholarly article

A role for WRN in telomere-based DNA damage responses is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2006PNAS..10315073E
P356DOI10.1073/PNAS.0607332103
P8608Fatcat IDrelease_myywllxlsndfbfg4igkycotite
P932PMC publication ID1586178
P698PubMed publication ID17015833
P5875ResearchGate publication ID6778922

P50authorHelena BackvallQ76400253
Vilhelm A. BohrQ89667423
Barbara GilchrestQ93373562
P2093author name stringMark S Eller
Patricia L Opresko
Xiaodong Liao
Helena Bäckvall
Kendra Hanna
SuiYang Liu
P2860cites workMammalian telomeres end in a large duplex loopQ22009893
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complexQ24298863
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomesQ24302611
A human telomeric proteinQ24304466
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicasesQ24304488
Nucleolar localization of the Werner syndrome protein in human cellsQ24323083
The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotidesQ24793800
Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2Q24793970
TRF2 Protects Human Telomeres from End-to-End FusionsQ28111898
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2Q28116237
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139Q28131715
The Werner syndrome protein: an updateQ28138573
How to activate p53Q28143809
Interaction of the Fanconi anemia proteins and BRCA1 in a common pathwayQ28203777
Telomere length regulationQ28290143
Senescence Induced by Altered Telomere State, Not Telomere LossQ28315731
DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletionQ28507823
p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2Q28609749
The Werner syndrome protein: an updateQ29544598
The serial cultivation of human diploid cell strainsQ29547356
DNA damage foci at dysfunctional telomeresQ29614811
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activityQ29615388
A DNA damage checkpoint response in telomere-initiated senescenceQ29615919
Protection of mammalian telomeresQ29618391
Stimulation of melanogenesis by DNA oligonucleotides: effect of size, sequence and 5' phosphorylationQ31871227
Functional human telomeres are recognized as DNA damage in G2 of the cell cycleQ33227804
Human telomeres maintain their overhang length at senescenceQ33707650
Requirement of ATM in phosphorylation of the human p53 protein at serine 15 following DNA double-strand breaksQ33957738
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process.Q34200511
Replicative life-span of cultivated human cells. Effects of donor's age, tissue, and genotypeQ34233470
TRF2 recruits the Werner syndrome (WRN) exonuclease for processing of telomeric DNA.Q34288672
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere statusQ34441492
Evidence that exposure of the telomere 3' overhang sequence induces senescenceQ34470102
Telomere dysfunction: multiple paths to the same end.Q34535652
Phosphorylation of H2AX at short telomeres in T cells and fibroblastsQ34550319
In vivostability and kinetics of absorption and disposition of 3' phosphopropyl amine oligonucleotidesQ35012323
Reversal of human cellular senescence: roles of the p53 and p16 pathwaysQ35561999
Senescence and immortalization: role of telomeres and telomeraseQ35912152
A DNA fragment with an alpha-phosphorothioate nucleotide at one end is asymmetrically blocked from digestion by exonuclease III and can be replicated in vivoQ36381814
Topical DNA oligonucleotide therapy reduces UV-induced mutations and photocarcinogenesis in hairless mice.Q37095361
Induction of apoptosis by telomere 3' overhang-specific DNA.Q38288992
Signaling pathway requirements for induction of senescence by telomere homolog oligonucleotidesQ38334543
Induction of a p95/Nbs1-mediated S phase checkpoint by telomere 3' overhang specific DNA.Q38358265
The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitroQ38361135
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.Q40481955
Telomere-based DNA damage responses: a new approach to melanomaQ40521591
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiationQ40570996
The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathwaysQ40584861
Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanismsQ40666765
Replicative senescence: an old lives' tale?Q40968415
Escape from senescence in human diploid fibroblasts induced directly by mutant p53.Q43459665
Molecular responses to photogenotoxic stress induced by the antibiotic lomefloxacin in human skin cells: from DNA damage to apoptosis.Q44553535
Werner syndrome protein contains three structure-specific DNA binding domainsQ44611028
Telomerase expression prevents replicative senescence but does not fully reset mRNA expression patterns in Werner syndrome cell strainsQ46330790
Kinetics of G-quartet-mediated tetramer formationQ46658951
Bypass of telomere-dependent replicative senescence (M1) upon overexpression of Cdk4 in normal human epithelial cells.Q52832311
Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.Q53422893
Checkpoints: How to activate p53Q56602132
Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cellsQ57250868
Werner syndrome cells escape hydrogen peroxide-induced cell proliferation arrestQ64048010
A role for both RB and p53 in the regulation of human cellular senescenceQ64378339
Erosion of the telomeric single-strand overhang at replicative senescenceQ73161631
Impaired nuclear localization of defective DNA helicases in Werner's syndromeQ73552946
P433issue41
P407language of work or nameEnglishQ1860
P921main subjectDNA damageQ5205747
P304page(s)15073-15078
P577publication date2006-10-02
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleA role for WRN in telomere-based DNA damage responses
P478volume103

Reverse relations

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