Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus

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Molecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1032871874
P356DOI10.1186/1750-1326-6-41
P932PMC publication ID3121598
P698PubMed publication ID21651786
P5875ResearchGate publication ID51200362

P50authorGurdeep MarwarhaQ42779729
P2093author name stringBhanu Dasari
Jaya Rp Prasanthi
Othman Ghribi
Jared Schommer
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Apoptotic neurons in Alzheimer's disease frequently show intracellular Abeta42 labeling.Q33184297
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Leptin: a novel therapeutic strategy for Alzheimer's diseaseQ34015256
Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slicesQ34075070
Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway.Q34155161
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Serum growth factors and neuroprotective surveillance: focus on IGF-1.Q34265977
β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathwayQ34267894
Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholineQ34474707
Microglia mediate the clearance of soluble Abeta through fluid phase macropinocytosisQ34554154
Databases on transcriptional regulation: TRANSFAC, TRRD and COMPELQ34650759
Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob miceQ34841988
Translational control of C/EBPalpha and C/EBPbeta isoform expression.Q35199785
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML.Q35751042
Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity.Q36146984
Growth hormone regulation of insulin-like growth factor-I gene expression may be mediated by multiple distal signal transducer and activator of transcription 5 binding sitesQ36578881
Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cellsQ36959116
The mammalian target of rapamycin complex 1 regulates leptin biosynthesis in adipocytes at the level of translation: the role of the 5'-untranslated region in the expression of leptin messenger ribonucleic acidQ36971815
The insulin/Akt signaling pathway is targeted by intracellular beta-amyloidQ37112633
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cellsQ37189912
Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimersQ77847011
Beyond nutrition: neuropeptide signaling and muscle mass maintenance in chronic kidney diseaseQ81556313
Differential expression of insulin-like growth factor genes in rat central nervous systemQ37481277
Defective STAT signaling by the leptin receptor in diabetic miceQ37509613
Leptin immunoreactivity is localized to neurons in rat brainQ38289768
Inhibition of preproinsulin gene expression by leptin induction of suppressor of cytokine signaling 3 in pancreatic beta-cellsQ38318483
Leptin action in intestinal cellsQ38333089
The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell lineQ38347442
Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridizationQ38356905
Phylogenetic position of the order Lagomorpha (rabbits, hares and allies)Q38564638
TRANSFAC, TRRD and COMPEL: towards a federated database system on transcriptional regulation.Q39718549
IGF-1 stimulates protein synthesis by enhanced signaling through mTORC1 in bovine mammary epithelial cellsQ39738168
Increased SULT1E1 activity in HepG2 hepatocytes decreases growth hormone stimulation of STAT5b phosphorylationQ39933161
The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanismsQ40088322
Hypoxia activates the IGF-1 expression through STAT5b in human HepG2 cellsQ40131696
The immunosuppressant rapamycin exacerbates neurotoxicity of Abeta peptideQ40235082
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Control of p70 s6 kinase by kinase activity of FRAP in vivoQ41284168
Adipocyte differentiation and leptin expressionQ41689365
The insulin and insulin-like growth factor-I receptor substrate IRS-1 associates with and activates phosphatidylinositol 3-kinase in vitroQ42810511
Regulation of adipocyte differentiation and insulin action with rapamycin.Q42825624
Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic miceQ44182586
Nutrient-sensing mTOR-mediated pathway regulates leptin production in isolated rat adipocytes.Q44185388
Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channelsQ44249848
Interaction between leptin and insulin signaling pathways differentially affects JAK-STAT and PI 3-kinase-mediated signaling in rat liver.Q44389682
Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expressionQ44908013
Obesity-related leptin regulates Alzheimer's AbetaQ45171528
Amyloid-beta interrupts the PI3K-Akt-mTOR signaling pathway that could be involved in brain-derived neurotrophic factor-induced Arc expression in rat cortical neuronsQ46081180
Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.Q46350343
In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and functionQ46771769
Circulating leptin levels and weight loss in Alzheimer's disease patientsQ47220287
Leptin immunoreactivity in the central nervous system in normal and diabetic ratsQ48236766
Specific uptake of Aβ1-40 in rat brain occurs in astrocyte, but not in microgliaQ48319506
Beta-amyloid peptide toxicity in organotypic hippocampal slice culture involves Akt/PKB, GSK-3beta, and PTEN.Q48405509
Serum insulin-like growth factor I regulates brain amyloid-beta levelsQ48454367
Localization of insulin-like growth factor-1 mRNA in murine central nervous system during postnatal developmentQ48661654
Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysisQ48704603
Insulin-like growth factor I mRNA levels are developmentally regulated in specific regions of the rat brainQ48740296
Leptin, peroxisome proliferator-activated receptor-gamma, and CCAAT/enhancer binding protein-alpha mRNA expression in adipose tissue of humans and their relation to cardiovascular risk factors.Q51558242
Use of serum insulin-like growth factor-I levels to predict psychiatric non-response to donepezil in patients with Alzheimer's disease.Q51900209
Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease.Q51945012
Insulin-like growth factors cross the blood-brain barrierQ52213519
Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.Q53218504
Protective and rescuing abilities of IGF-I and some putative free radical scavengers against beta-amyloid-inducing toxicity in neurons.Q53232949
FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive ConditionsQ57371808
Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neuronsQ74154135
Regulation of leptin promoter function by Sp1, C/EBP, and a novel factorQ74278137
P433issue1
P304page(s)41
P577publication date2011-06-08
P1433published inMolecular NeurodegenerationQ15817329
P1476titleMolecular interplay between leptin, insulin-like growth factor-1, and β-amyloid in organotypic slices from rabbit hippocampus
P478volume6

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cites work (P2860)
Q38630244Beneficial Effect of Leptin on Spatial Learning and Memory in Streptozotocin-Induced Diabetic Rats
Q37347999Combining radiotherapy with MEK1/2, STAT5 or STAT6 inhibition reduces survival of head and neck cancer lines
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