Birth, life and death of nascent polypeptide chains.

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Birth, life and death of nascent polypeptide chains. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1002/BIOT.201000327
P932PMC publication ID3130931
P698PubMed publication ID21538896
P5875ResearchGate publication ID51094840

P50authorAnton KomarQ56224301
P2093author name stringSujata Jha
P2860cites workThe ribosomal tunnel as a functional environment for nascent polypeptide folding and translational stallingQ37840649
Proteolytic processing of picornaviral polyproteinQ38004542
Cotranslational folding of globinQ38346734
A tunnel in the large ribosomal subunit revealed by three-dimensional image reconstructionQ69004129
Acylation of proteins with myristic acid occurs cotranslationallyQ69457820
Role of the code redundancy in determining cotranslational protein foldingQ69648000
Translationally associated helix-destabilizing activity in rabbit reticulocyte lysateQ72406218
Synonymous codon substitutions affect ribosome traffic and protein folding during in vitro translationQ73327926
Secondary structure formation of a transmembrane segment in Kv channelsQ81818122
Co-translational binding of GroEL to nascent polypeptides is followed by post-translational encapsulation by GroES to mediate protein foldingQ83929508
Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recyclingQ24296405
The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complexQ24307372
A protein complex required for signal-sequence-specific sorting and translocationQ24315826
Human N-myristoyltransferase amino-terminal domain involved in targeting the enzyme to the ribosomal subcellular fractionQ24323068
The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptidesQ24653224
The complete atomic structure of the large ribosomal subunit at 2.4 A resolutionQ27626400
A peptide deformylase-ribosome complex reveals mechanism of nascent chain processingQ27649896
Structure of Monomeric Yeast and Mammalian Sec61 Complexes Interacting with the Translating RibosomeQ27658307
Structural insight into nascent polypeptide chain-mediated translational stalling.Q27658309
Recognition of a signal peptide by the signal recognition particleQ27660413
Cryo-EM structure and rRNA model of a translating eukaryotic 80S ribosome at 5.5-A resolutionQ27665394
Crystal structure of the eukaryotic ribosomeQ27666069
Cryo-EM structure of the E. coli translating ribosome in complex with SRP and its receptorQ27666368
Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1Q27666453
The Sec translocaseQ27691857
RING domain E3 ubiquitin ligasesQ27860546
A functional chaperone triad on the yeast ribosomeQ27930569
Systems analyses reveal two chaperone networks with distinct functions in eukaryotic cellsQ27932599
N-terminal acetyltransferases and sequence requirements for N-terminal acetylation of eukaryotic proteinsQ27932762
Role of a ribosome-associated E3 ubiquitin ligase in protein quality controlQ27936843
Yeast methionine aminopeptidase type 1 is ribosome-associated and requires its N-terminal zinc finger domain for normal function in vivo.Q27937078
RAC, a stable ribosome-associated complex in yeast formed by the DnaK-DnaJ homologs Ssz1p and zuotin.Q27938678
Nascent-polypeptide-associated complexQ28217074
Signal peptidasesQ28217085
Principles that govern the folding of protein chainsQ28236872
Human Mpp11 J protein: ribosome-tethered molecular chaperones are ubiquitousQ28242853
Tissue-specific differences in human transfer RNA expressionQ28469081
The mechanism of eukaryotic translation initiation and principles of its regulationQ29547270
Molecular chaperones and protein quality controlQ29617795
Codon usage and tRNA content in unicellular and multicellular organismsQ29618300
Folding of newly translated proteins in vivo: the role of molecular chaperonesQ29619368
A "silent" polymorphism in the MDR1 gene changes substrate specificityQ29619435
Identification of an SH3-binding motif in a new class of methionine aminopeptidases from Mycobacterium tuberculosis suggests a mode of interaction with the ribosomeQ30160246
Ribosomal pausing at a frameshifter RNA pseudoknot is sensitive to reading phase but shows little correlation with frameshift efficiencyQ39529314
23S rRNA assisted folding of cytoplasmic malate dehydrogenase is distinctly different from its self-foldingQ39615665
The path of the growing peptide chain through the 23S rRNA in the 50S ribosomal subunit; a comparative cross-linking study with three different peptide familiesQ39722844
Identification of nascent chain interaction sites on trigger factorQ40171796
Mapping the path of the nascent peptide chain through the 23S in the 50S ribosomal subunitQ40394669
Contacts between the growing peptide chain and the 23S RNA in the 50S ribosomal subunitQ40399358
Signal sequence recognition and protein targeting to the endoplasmic reticulum membraneQ40611469
Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.Q40883590
Nonuniform size distribution of nascent peptides. The effect of messenger RNA structure upon the rate of translationQ41044314
Controlled proteolysis of nascent polypeptides in rat liver cell fractions. I. Location of the polypeptides within ribosomesQ41121462
The efficiency of folding of some proteins is increased by controlled rates of translation in vivo. A hypothesisQ41429992
alpha-Helical nascent polypeptide chains visualized within distinct regions of the ribosomal exit tunnelQ41619420
Three-dimensional structures of translating ribosomes by Cryo-EM.Q41628474
Nascent peptide-dependent translation arrest leads to Not4p-mediated protein degradation by the proteasomeQ41927521
Effects on translation pausing of alterations in protein and RNA components of the ribosome exit tunnelQ42406802
Nascent peptide in the ribosome exit tunnel affects functional properties of the A-site of the peptidyl transferase centerQ42688854
Translation of the poly(A) tail plays crucial roles in nonstop mRNA surveillance via translation repression and protein destabilization by proteasome in yeastQ42924383
Stereochemical analysis of ribosomal transpeptidation. Conformation of nascent peptideQ43424112
Does the channel for nascent peptide exist inside the ribosome? Immune electron microscopy studyQ43431144
Flexibility of the nascent polypeptide chain within the ribosome--contacts from the peptide N-terminus to a specific region of the 30S subunitQ43656210
L23 protein functions as a chaperone docking site on the ribosomeQ44134061
Instruction of translating ribosome by nascent peptideQ44135169
Detecting and measuring cotranslational protein degradation in vivoQ44397626
Trigger factor peptidyl-prolyl cis/trans isomerase activity is not essential for the folding of cytosolic proteins in Escherichia coliQ44732908
[Role of the rare codon clusters in defining the boundaries of polypeptide chain regions with identical secondary structures in the process of co-translational folding of proteins]Q44969368
Nonuniform size distribution of nascent globin peptides, evidence for pause localization sites, and a cotranslational protein-folding modelQ44984080
Human catechol-O-methyltransferase haplotypes modulate protein expression by altering mRNA secondary structure.Q45345781
Features of ribosome-peptidyl-tRNA interactions essential for tryptophan induction of tna operon expressionQ46227073
Folding zones inside the ribosomal exit tunnelQ46813554
Gel chromatographic analysis of nascent globin chains. Evidence of nonuniform size distribution.Q47357823
Partial resistance of nascent polypeptide chains to proteolytic digestion due to ribosomal shieldingQ47708573
Nascent membrane and secretory proteins differ in FRET-detected folding far inside the ribosome and in their exposure to ribosomal proteins.Q47987631
Folding of the MS2 coat protein in Escherichia coli is modulated by translational pauses resulting from mRNA secondary structure and codon usage: a hypothesis.Q49168556
Transient ribosomal attenuation coordinates protein synthesis and co-translational folding.Q51836617
An analysis of the helix-to-strand transition between peptides with identical sequence.Q52074685
Signal recognition particle binds to ribosome-bound signal sequences with fluorescence-detected subnanomolar affinity that does not diminish as the nascent chain lengthens.Q52842432
The functional half-life of an mRNA depends on the ribosome spacing in an early coding region.Q54369921
Translation arrest requires two-way communication between a nascent polypeptide and the ribosome.Q54463767
Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins.Q54500735
Growth rate-optimised tRNA abundance and codon usage.Q54561817
Ribosomes and ribosomal RNA as chaperones for folding of proteins.Q54573724
The "+70 pause": hypothesis of a translational control of membrane protein assembly.Q54580621
[Is there a channel for a peptide synthesized on a ribosome? Labeling of translating ribosomes with atomic tritium]Q54771320
Mapping the electrostatic potential within the ribosomal exit tunnelQ57132363
The Geometry of the Ribosomal Polypeptide Exit TunnelQ57954617
Opportunism knocks?Q59079003
Role of the ribosome in protein foldingQ63378946
Ribosomes pause at specific sites during synthesis of membrane-bound chloroplast reaction center protein D1Q67941202
Nascent polypeptide chains emerge from the exit domain of the large ribosomal subunit: immune mapping of the nascent chainQ36295457
Nascent peptide in the "birth canal" of the ribosomeQ36335638
Conserved residues Asp16 and Pro24 of TnaC-tRNAPro participate in tryptophan induction of Tna operon expressionQ36747828
The ribosomal peptidyl transferaseQ36820538
Origins and evolution of cotranslational transport to the ER.Q36988945
Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minimaQ37066299
Multiple conformational switches in a GTPase complex control co-translational protein targetingQ37100829
Modulating the activity of the peptidyl transferase center of the ribosome.Q37120124
Tertiary interactions within the ribosomal exit tunnelQ37161999
Folding at the rhythm of the rare codon beatQ37215108
The plasticity of a translation arrest motif yields insights into nascent polypeptide recognition inside the ribosome tunnelQ37245890
A pause for thought along the co-translational folding pathwayQ37321409
A structural view of translation initiation in bacteriaQ37326466
Recent mechanistic insights into eukaryotic ribosomesQ37401502
The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries.Q37462924
The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteinsQ37506110
Cotranslational processing mechanisms: towards a dynamic 3D modelQ37568889
Interaction of secreted nascent chains with surrounding membrane in Bacillus subtilisQ37595984
Silent (synonymous) SNPs: should we care about them?Q37600712
N-glycan structures: recognition and processing in the ER.Q37620688
Divergent stalling sequences sense and control cellular physiology.Q37684316
Protein folding on the ribosomeQ37690961
Early targeting events during membrane protein biogenesis in Escherichia coliQ37777484
Protein acetylation in archaea, bacteria, and eukaryotesQ37795592
Participation of lectin chaperones and thiol oxidoreductases in protein folding within the endoplasmic reticulumQ37811281
Adjustment of codon usage frequencies by codon harmonization improves protein expression and foldingQ37815057
Combining experiment and simulation in protein folding: closing the gap for small model systemsQ31145148
Peptide deformylase as an antibacterial target: a critical assessmentQ33253699
Protein folding by domain V of Escherichia coli 23S rRNA: specificity of RNA-protein interactionsQ33321822
Rare codons clusterQ33377033
A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substratesQ33491261
The ribosome-bound Hsp70 homolog Ssb of Saccharomyces cerevisiaeQ33540464
Transient tertiary structure formation within the ribosome exit portQ33742605
A folding zone in the ribosomal exit tunnel for Kv1.3 helix formationQ33831957
Structure and function of the methionine aminopeptidasesQ33857472
Binding specificity of Escherichia coli trigger factorQ33951759
What recent ribosome structures have revealed about the mechanism of translationQ34019810
An evolutionarily conserved mechanism for controlling the efficiency of protein translationQ34022113
A role for codon order in translation dynamics.Q34022117
Codon usage patterns in Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster and Homo sapiens; a review of the considerable within-species diversityQ34049097
N-terminal acetylation of cellular proteins creates specific degradation signalsQ34095411
Structure and function of the molecular chaperone Trigger Factor.Q34096951
The ribosomal exit tunnel functions as a discriminating gateQ34118341
Post-translational myristoylation: Fat matters in cellular life and deathQ34148521
The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptideQ34148533
N(α)-Acetylation of yeast ribosomal proteins and its effect on protein synthesisQ34156533
The Ribosome Comes AliveQ34292076
Localization of eukaryote-specific ribosomal proteins in a 5.5-Å cryo-EM map of the 80S eukaryotic ribosomeQ34359294
Sequence requirements for ribosome stalling by the arginine attenuator peptideQ34412752
Organellar peptide deformylases: universality of the N-terminal methionine cleavage mechanism.Q34460014
An evolving view of the eukaryotic oligosaccharyltransferaseQ34471377
Hearing silence: non-neutral evolution at synonymous sites in mammalsQ34485607
Yeast N(alpha)-terminal acetyltransferases are associated with ribosomesQ34633391
Three-dimensional electron cryomicroscopy of ribosomesQ34948162
Control of SecA and SecM translation by protein secretionQ35737959
Theory of protein foldingQ35753216
Protein N-terminal methionine excision.Q35805452
Unraveling the mechanism of protein N-glycosylationQ35980135
NAC covers ribosome-associated nascent chains thereby forming a protective environment for regions of nascent chains just emerging from the peptidyl transferase centerQ36235831
Molecular guardians for newborn proteins: ribosome-associated chaperones and their role in protein foldingQ36288962
P275copyright licenseCreative Commons Attribution 2.5 GenericQ18810333
P433issue6
P921main subjectmessenger RNAQ188928
protein biosynthesisQ211935
peptideQ172847
cellQ7868
P304page(s)623-640
P577publication date2011-04-29
2011-06-01
P1433published inBiotechnology JournalQ15716480
P1476titleBirth, life and death of nascent polypeptide chains
P478volume6

Reverse relations

cites work (P2860)
Q41909628"Naked" FACT is unstable.
Q36846535Autotransporters: The Cellular Environment Reshapes a Folding Mechanism to Promote Protein Transport
Q36978293Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex
Q39222310Folding of proteins with a flavodoxin-like architecture
Q38027048Isolation of ribosome bound nascent polypeptides in vitro to identify translational pause sites along mRNA.
Q30485422Large-scale analysis of conserved rare codon clusters suggests an involvement in co-translational molecular recognition events
Q55487507Modeling protein folding in vivo.
Q61800363Molecular interactions between Hel2 and RNA supporting ribosome-associated quality control
Q28118314Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design
Q27027216The Not4 RING E3 Ligase: A Relevant Player in Cotranslational Quality Control
Q34438774The cell-free integration of a polytopic mitochondrial membrane protein into liposomes occurs cotranslationally and in a lipid-dependent manner
Q37957794The role of RNA in mammalian prion protein conversion
Q37924093Understanding the contribution of synonymous mutations to human disease

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