Gremlin1 is required for skeletal development and postnatal skeletal homeostasis

scientific article

Gremlin1 is required for skeletal development and postnatal skeletal homeostasis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JCP.22730
P932PMC publication ID3132213
P698PubMed publication ID21412775
P5875ResearchGate publication ID50410280

P50authorErnesto CanalisQ56269284
Stefano ZanottiQ56269901
Kristen ParkerQ117248443
P2093author name stringErnesto Canalis
P2860cites workGuidelines for assessment of bone microstructure in rodents using micro-computed tomographyQ37763651
Effect of primary and secondary structure of oligodeoxyribonucleotides on the fluorescent properties of conjugated dyesQ39600740
Multiplex quantitative PCR using self-quenched primers labeled with a single fluorophoreQ39600850
Notch 1 overexpression inhibits osteoblastogenesis by suppressing Wnt/beta-catenin but not bone morphogenetic protein signalingQ40331060
Expression of the BMP 2 gene during bone cell differentiation.Q40607137
Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cellsQ41638851
The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways.Q42823613
Protein related to DAN and cerberus is a bone morphogenetic protein antagonist that participates in ovarian paracrine regulationQ44811143
Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strengthQ46186977
Age-related changes in trabecular architecture differ in female and male C57BL/6J mice.Q51009028
C/EBP homologous protein is necessary for normal osteoblastic function.Q53566901
Skeletal Overexpression of Noggin Results in Osteopenia and Reduced Bone FormationQ57936901
Bone morphogenetic proteins in bone stimulate osteoclasts and osteoblasts during bone developmentQ79822578
Activation of the ERK pathway in osteoblastic cells, role of gremlin and BMP-2Q80735928
Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone massQ83924358
Skeletal overexpression of gremlin impairs bone formation and causes osteopeniaQ24314447
The Xenopus dorsalizing factor Gremlin identifies a novel family of secreted proteins that antagonize BMP activitiesQ24314690
Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strengthQ28274891
Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteinsQ28293474
Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosisQ28302443
Gremlin-mediated BMP antagonism induces the epithelial-mesenchymal feedback signaling controlling metanephric kidney and limb organogenesisQ28506504
Gremlin is the BMP antagonist required for maintenance of Shh and Fgf signals during limb patterningQ28507504
Identification of drm, a novel gene whose expression is suppressed in transformed cells and which can inhibit growth of normal but not transformed cells in cultureQ28576024
Biosynthesis, post-translation modification, and functional characterization of Drm/GremlinQ28578839
Bone histomorphometry: standardization of nomenclature, symbols, and units. Report of the ASBMR Histomorphometry Nomenclature CommitteeQ29616160
Generation and Selection of Novel Fully Human Monoclonal Antibodies That Neutralize Dickkopf-1 (DKK1) Inhibitory Function in Vitro and Increase Bone Mass in VivoQ30497635
Validation of peripheral dual-energy X-ray absorptiometry for the measurement of bone mineral in intact and excised long bones of ratsQ31970416
Signal transduction by bone morphogenetic protein receptors: functional roles of Smad proteinsQ33697455
Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblastsQ33927389
Connective tissue growth factor is required for skeletal development and postnatal skeletal homeostasis in male miceQ34132427
Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferationQ34569128
Bone morphogenetic proteins and their antagonistsQ34572394
Conditional deletion of gremlin causes a transient increase in bone formation and bone massQ34676851
Bone morphogenetic proteins, their antagonists, and the skeletonQ35109618
Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts.Q35156225
The CCN family: a new stimulus packageQ35194555
Wnt signaling in osteoblasts and bone diseasesQ35913119
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-betaQ36663630
Skeletal overexpression of connective tissue growth factor impairs bone formation and causes osteopeniaQ36908891
BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.Q37222697
Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblastsQ37388231
Enhanced osteoclastogenesis causes osteopenia in twisted gastrulation-deficient mice through increased BMP signalingQ37396641
Phosphatidylinositol 3 kinase/Akt signal relay cooperates with smad in bone morphogenetic protein-2-induced colony stimulating factor-1 (CSF-1) expression and osteoclast differentiationQ37418214
P433issue1
P304page(s)269-277
P577publication date2012-01-01
P1433published inJournal of Cellular PhysiologyQ1524270
P1476titleGremlin1 is required for skeletal development and postnatal skeletal homeostasis
P478volume227

Reverse relations

cites work (P2860)
Q36132931A soluble bone morphogenetic protein type IA receptor increases bone mass and bone strength
Q36219733Adipose Tissue Residing Progenitors (Adipocyte Lineage Progenitors and Adipose Derived Stem Cells (ADSC).
Q38896053Agonists and Antagonists of TGF-β Family Ligands
Q36889250Bone mineral properties in growing Col1a2(+/G610C) mice, an animal model of osteogenesis imperfecta
Q35872773Conditional inactivation of noggin in the postnatal skeleton causes osteopenia
Q46012172Expression of Noggin and Gremlin1 and its implications in fine-tuning BMP activities in mouse cartilage tissues.
Q27323315Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.
Q33867359Gremlin1 plays a key role in kidney development and renal fibrosis
Q38942069Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7.
Q35755147High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes
Q91688877New Insights on Properties and Spatial Distributions of Skeletal Stem Cells
Q44824506Use of locally weighted scatterplot smoothing (LOWESS) regression to study selection signatures in Piedmontese and Italian Brown cattle breeds.

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