Bridging molecular genetics and biomarkers in lewy body and related disorders

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Bridging molecular genetics and biomarkers in lewy body and related disorders is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.4061/2011/842475
P932PMC publication ID3132544
P698PubMed publication ID21760990
P5875ResearchGate publication ID51494337

P50authorEliezer MasliahQ28324209
P2093author name stringMasaaki Waragai
Makoto Hashimoto
Kazunari Sekiyama
Gilbert J Ho
Willie Liang
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Parkinson's disease-associated parkin colocalizes with Alzheimer's disease and multiple sclerosis brain lesionsQ39806585
Expression and role of DJ-1 in leukemiaQ39947928
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Synuclein activates microglia in a model of Parkinson's diseaseQ40126232
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Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.Q40405368
A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.Q40601003
Influence of Alzheimer pathology on clinical diagnostic accuracy in dementia with Lewy bodiesQ42442006
Mapping of brain acetylcholinesterase alterations in Lewy body disease by PET.Q42454450
DJ-1 degrades transthyretin and an inactive form of DJ-1 is secreted in familial amyloidotic polyneuropathy.Q42828536
LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.Q42873469
Association of an interleukin 1B gene polymorphism (-511) with Parkinson's disease in Finnish patientsQ43074720
Decreased cardiac MIBG uptake, its correlation with clinical symptoms in dementia with Lewy bodiesQ43274217
Severity of neuropsychiatric symptoms and dopamine transporter levels in dementia with Lewy bodies: a 123I-FP-CIT SPECT study.Q43286528
Correlation between changes in CSF dopamine turnover and development of dyskinesia in Parkinson's disease.Q43792598
A mutation in the human neurofilament M gene in Parkinson's disease that suggests a role for the cytoskeleton in neuronal degenerationQ43962617
Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231.Q44091581
Assessment of CSF homovanillic acid levels distinguishes dementia with Lewy bodies from Alzheimer's diseaseQ44208377
Dopamine transporter loss visualized with FP-CIT SPECT in the differential diagnosis of dementia with Lewy bodies.Q44946964
Value of 123I-MIBG radioactivity in the differential diagnosis of DLB from AD.Q45135867
Clinical genetic analysis of Parkinson's disease in the Contursi kindredQ45235440
Improved discrimination of autopsy-confirmed Alzheimer's disease (AD) from non-AD dementias using CSF P-tau(181P).Q45970470
Inflammatory cytokine gene polymorphisms and increased risk of Parkinson diseaseQ46072995
Human recombinant NACP/alpha-synuclein is aggregated and fibrillated in vitro: relevance for Lewy body diseaseQ46084408
Quantitative proteomic analysis of mitochondrial proteins: relevance to Lewy body formation and Parkinson's diseaseQ46404066
Gene expression profiling of Lewy body-bearing neurons in Parkinson's diseaseQ46535275
Cardiac (123)I-metaiodobenzylguanidine imaging allows early identification of dementia with Lewy bodies during lifeQ46569969
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's diseaseQ46683999
DJ-1 is essential for long-term depression at hippocampal CA1 synapsesQ46774588
Comparative value of brain perfusion SPECT and [(123)I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer's diseaseQ46836076
Neuropathology provides clues to the pathophysiology of Gaucher diseaseQ47247270
DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementiaQ48101646
Dementia with Lewy bodies: choline acetyltransferase parallels nucleus basalis pathologyQ48139333
The impact of the E46K mutation on the properties of alpha-synuclein in its monomeric and oligomeric statesQ48155270
Imaging beta-amyloid burden in aging and dementia.Q48168226
Alpha-synuclein implicated in Parkinson's disease is present in extracellular biological fluids, including human plasmaQ48183703
Diagnostic markers for diagnosing dementia with Lewy bodies: CSF and MIBG cardiac scintigraphy studyQ48188599
Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patientsQ48191627
Cerebrospinal fluid markers in dementia with lewy bodies compared with Alzheimer diseaseQ48198034
Diffusion tensor imaging in dementia with Lewy bodies and Alzheimer's diseaseQ48217265
Proteomic identification of novel proteins in cortical lewy bodiesQ48227693
Sensitivity and specificity of dopamine transporter imaging with 123I-FP-CIT SPECT in dementia with Lewy bodies: a phase III, multicentre studyQ48240563
Plasma alpha-synuclein is decreased in subjects with Parkinson's diseaseQ48295840
The cerebrospinal fluid amyloid beta42/40 ratio in the differentiation of Alzheimer's disease from non-Alzheimer's dementiaQ48360091
Interleukin-6 levels in cerebrospinal fluid inversely correlate to severity of Parkinson's diseaseQ48402580
Glucocerebrosidase mutations are an important risk factor for Lewy body disorders.Q48491146
Diagnostic performance of a CSF-biomarker panel in autopsy-confirmed dementia.Q51976242
CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from dementia with Lewy bodies. Phospho-Tau International Study Group.Q52057738
Remarkable reduction in acetylcholine concentration in the cerebrospinal fluid from patients with Alzheimer type dementia.Q53203247
Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.Q53213249
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Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions.Q53315139
Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.Q53417610
α-synuclein antibodies recognize a protein present at lower levels in the CSF of patients with dementia with Lewy bodiesQ57947893
Polymorphism in the human DJ-1 gene is not associated with sporadic dementia with Lewy bodies or Parkinson's diseaseQ63194317
Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson's diseaseQ64784256
Influence of interleukin-1beta gene polymorphisms on age-at-onset of sporadic Parkinson's diseaseQ64786053
Increased cerebrospinal fluid levels of neurofilament protein in progressive supranuclear palsy and multiple-system atrophy compared with Parkinson's diseaseQ64922770
Localization of phosphoneuroprotein 14 (PNP 14) and its mRNA expression in rat brain determined by immunocytochemistry and in situ hybridizationQ72595899
18F-fluorodopa PET study of striatal dopamine uptake in the diagnosis of dementia with Lewy bodiesQ73230794
Cerebrospinal fluid tau levels in neurodegenerative diseases with distinct tau-related pathologyQ73551190
Glucocerebrosidase level in the cerebrospinal fluid during enzyme replacement therapy--unsuccessful treatment of the neurological abnormality in type 2 Gaucher diseaseQ73622229
Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutationQ79267853
Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's diseaseQ80424021
Plasma levels of DJ-1 as a possible marker for progression of sporadic Parkinson's diseaseQ80845388
Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onsetQ81147302
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Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's diseaseQ82686303
Increased incidence of Parkinson disease among relatives of patients with Gaucher diseaseQ83228051
Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy BodiesQ83514686
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Alpha-Synuclein contributes to GSK-3beta-catalyzed Tau phosphorylation in Parkinson's disease modelsQ33552220
Leucine-rich repeat kinase 2 regulates the progression of neuropathology induced by Parkinson's-disease-related mutant alpha-synuclein.Q33594388
Distinct region-specific alpha-synuclein oligomers in A53T transgenic mice: implications for neurodegenerationQ33747872
Lysosomal degradation of alpha-synuclein in vivo.Q33810012
Molecular genetics of Alzheimer's disease.Q33842568
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beta-Synuclein inhibits alpha-synuclein aggregation: a possible role as an anti-parkinsonian factorQ34099593
Biomarker discovery in neurodegenerative diseases: a proteomic approach.Q34125681
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The neuropathology and biochemistry of frontotemporal dementiaQ34209946
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Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.Q34303003
The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous systemQ34318718
Demonstration of a role for alpha-synuclein as a functional microtubule-associated proteinQ34345614
Mutations in the glucocerebrosidase gene and Parkinson's disease in Ashkenazi JewsQ34365028
Snaring the function of alpha-synucleinQ34465204
Effect of familial Parkinson's disease point mutations A30P and A53T on the structural properties, aggregation, and fibrillation of human alpha-synucleinQ34517780
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Alpha-synuclein can function as an antioxidant preventing oxidation of unsaturated lipid in vesiclesQ34541894
Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the consortium on DLB international workshopQ34736093
Gaucher disease and the synucleinopathiesQ34795306
Aggregation and neurotoxicity of alpha-synuclein and related peptidesQ34797480
alpha-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activityQ34980191
LRRK2 in Parkinson's disease and dementia with Lewy bodiesQ35214380
Parkinsonism among Gaucher disease carriersQ35444509
Gaucher disease: complexity in a "simple" disorderQ35908938
Neurofilament proteins in neurodegenerative diseasesQ35975762
Tau phosphorylation: physiological and pathological consequencesQ35992168
Mechanisms of cell signaling and inflammation in Alzheimer's diseaseQ36107658
Dementia with Lewy bodies: a comparison of clinical diagnosis, FP-CIT single photon emission computed tomography imaging and autopsy.Q36226812
CSF neurofilament proteins in the differential diagnosis of dementiaQ36227579
Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer diseaseQ36426239
Association of alpha-, beta-, and gamma-Synuclein with diffuse lewy body diseaseQ36504239
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectbiomarkerQ864574
P304page(s)842475
P577publication date2011-07-03
P1433published inInternational journal of Alzheimer's diseaseQ27722932
P1476titleBridging molecular genetics and biomarkers in lewy body and related disorders
P478volume2011

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cites work (P2860)
Q64085064A proteomic signature for dementia with Lewy bodies
Q38283550Biomarkers in biological fluids for dementia with Lewy bodies

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