DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair

scientific article

DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKU1307
P932PMC publication ID4333375
P698PubMed publication ID25539916
P5875ResearchGate publication ID270002937

P50authorMichael J. HendzelQ42407069
P2093author name stringGuy G Poirier
Michael Weinfeld
Ismail Abdou
P2860cites workDNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formationQ21144955
The role of poly(ADP-ribose) in the DNA damage signaling networkQ22306473
Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cellsQ24313256
The DNA ligase III zinc finger stimulates binding to DNA secondary structure and promotes end joiningQ24523839
An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase IIIQ24615666
Two DNA-binding and nick recognition modules in human DNA ligase IIIQ24646413
PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibilityQ24653009
The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc FingerQ27666697
Genome maintenance mechanisms for preventing cancerQ28131737
DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatinQ28236172
Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repairQ28248511
Role of a BRCT domain in the interaction of DNA ligase III-alpha with the DNA repair protein XRCC1Q28279796
DNA Topoisomerase I Inhibitors: Chemistry, Biology, and Interfacial InhibitionQ29400901
Single-strand break repair and genetic diseaseQ29615347
PARP inhibition: PARP1 and beyondQ29619617
Comparative analysis of different laser systems to study cellular responses to DNA damage in mammalian cellsQ30487741
Differential recruitment of DNA Ligase I and III to DNA repair sitesQ33251083
Activation of multiple DNA repair pathways by sub-nuclear damage induction methodsQ33291497
Feedback-regulated poly(ADP-ribosyl)ation by PARP-1 is required for rapid response to DNA damage in living cellsQ33304975
PARP1-dependent kinetics of recruitment of MRE11 and NBS1 proteins to multiple DNA damage sitesQ33306325
DNA ligase III is recruited to DNA strand breaks by a zinc finger motif homologous to that of poly(ADP-ribose) polymerase. Identification of two functionally distinct DNA binding regions within DNA ligase III.Q33869047
XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damageQ33970153
Sensing DNA damage by PARP-like fingersQ33987203
Involvement of XRCC1 and DNA ligase III gene products in DNA base excision repair.Q34439025
Poly(ADP-ribose) polymerase and XPF-ERCC1 participate in distinct pathways for the repair of topoisomerase I-induced DNA damage in mammalian cellsQ34946954
Using FRAP and mathematical modeling to determine the in vivo kinetics of nuclear proteins.Q35051219
Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repairQ35099098
Disconnecting XRCC1 and DNA ligase IIIQ35878514
Base excision repair and design of small molecule inhibitors of human DNA polymerase β.Q35882620
A requirement for PARP-1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damageQ36119231
The interaction between polynucleotide kinase phosphatase and the DNA repair protein XRCC1 is critical for repair of DNA alkylation damage and stable association at DNA damage sitesQ36385995
Repair of topoisomerase I-mediated DNA damageQ36557533
XRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaksQ36629377
Distinct spatiotemporal patterns and PARP dependence of XRCC1 recruitment to single-strand break and base excision repairQ36684843
Protein ADP-ribosylation and the cellular response to DNA strand breaksQ38206322
Base excision repair is efficient in cells lacking poly(ADP-ribose) polymerase 1.Q39584636
Poly (ADP-ribose) polymerase (PARP) is not involved in base excision repair but PARP inhibition traps a single-strand intermediateQ39616281
XRCC1 polypeptide interacts with DNA polymerase beta and possibly poly (ADP-ribose) polymerase, and DNA ligase III is a novel molecular 'nick-sensor' in vitroQ39718210
Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.Q40529875
Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymeraseQ43839560
DNA strand break and rejoining in cultured human fibroblasts exposed to fast neutrons or gamma raysQ64390625
PCR Mutagenesis by Overlap Extension and Gene SOEQ83488138
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)875-892
P577publication date2014-12-24
P1433published inNucleic Acids ResearchQ135122
P1476titleDNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair
P478volume43

Reverse relations

cites work (P2860)
Q26853144Alternative Okazaki Fragment Ligation Pathway by DNA Ligase III
Q35961937Human DNA ligase III bridges two DNA ends to promote specific intermolecular DNA end joining
Q47154064Meta-analysis of DNA double-strand break response kinetics
Q35690306Micro-irradiation tools to visualize base excision repair and single-strand break repair
Q33557991Microhomology-mediated end joining is activated in irradiated human cells due to phosphorylation-dependent formation of the XRCC1 repair complex
Q28608504Nuclear Localization of the DNA Repair Scaffold XRCC1: Uncovering the Functional Role of a Bipartite NLS
Q38726326Overlapping roles for PARP1 and PARP2 in the recruitment of endogenous XRCC1 and PNKP into oxidized chromatin
Q38296607Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein.
Q33580476Tankyrase1-mediated poly(ADP-ribosyl)ation of TRF1 maintains cell survival after telomeric DNA damage
Q42292345The DNA repair function of CUX1 contributes to radioresistance
Q49605139The Role of DNA Repair in Maintaining Mitochondrial DNA Stability
Q35679372The XRCC1 phosphate-binding pocket binds poly (ADP-ribose) and is required for XRCC1 function
Q49872152The small GTPase RhoU lays downstream of JAK/STAT signaling and mediates cell migration in multiple myeloma.
Q47445015XRCC1-mediated repair of strand breaks independent of PNKP binding.

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