Membrane type-matrix metalloproteinases (MT-MMP)

scientific article published on January 1, 2003

Membrane type-matrix metalloproteinases (MT-MMP) is …
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scholarly articleQ13442814

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P356DOI10.1016/S0070-2153(03)54004-2
P698PubMed publication ID12696745

P50authorCarlos López OtínQ2919877
P2093author name stringDuanqing Pei
Jian Cao
Stanley Zucker
P2860cites workCloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family membersQ22001456
Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumorsQ22009965
Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumorsQ22253287
Membrane-type 6 matrix metalloproteinase (MT6-MMP, MMP-25) is the second glycosyl-phosphatidyl inositol (GPI)-anchored MMPQ24290409
Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injuryQ24290646
Suppression of membrane-type 1 matrix metalloproteinase (MMP)-mediated MMP-2 activation and tumor invasion by testican 3 and its splicing variant gene product, N-TesQ24292053
Identification of the second membrane-type matrix metalloproteinase (MT-MMP-2) gene from a human placenta cDNA library. MT-MMPs form a unique membrane-type subclass in the MMP familyQ24310476
A matrix metalloproteinase expressed on the surface of invasive tumour cellsQ24312733
Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertasesQ24550531
Transmembrane transforming growth factor-alpha tethers to the PDZ domain-containing, Golgi membrane-associated protein p59/GRASP55Q24595955
Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysmsQ24623052
Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitorQ27729709
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1Q27742927
Furin-dependent intracellular activation of the human stromelysin-3 zymogenQ28115242
cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane SegmentQ28115693
Cloning of three Caenorhabditis elegans genes potentially encoding novel matrix metalloproteinasesQ28116117
Tissue inhibitors of metalloproteinases: evolution, structure and functionQ28138083
Domain interactions in the gelatinase A.TIMP-2.MT1-MMP activation complex. The ectodomain of the 44-kDa form of membrane type-1 matrix metalloproteinase does not modulate gelatinase A activationQ28138867
Tenascin-C in development and disease: gene regulation and cell functionQ28139238
Matrix metalloproteinasesQ28140451
Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XIIQ28142828
Collagenase-3 binds to a specific receptor and requires the low density lipoprotein receptor-related protein for internalizationQ28145656
Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinasesQ28198043
Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regenerationQ28203290
Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndromeQ28204201
Upregulated expression of human membrane type-5 matrix metalloproteinase in kidneys from diabetic patientsQ28206832
The hemopexin-like C-terminal domain of membrane type 1 matrix metalloproteinase regulates proteolysis of a multifunctional protein, gC1qRQ28214381
Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion.Q28215016
Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13)Q28236176
Induction of Cell Migration by Matrix Metalloprotease-2 Cleavage of Laminin-5Q28242922
Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by alternatively spliced mRNAQ28256375
Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP)Q28258413
Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domainQ28278203
Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzymeQ28282027
The human collagenase-3 (CLG3) gene is located on chromosome 11q22.3 clustered to other members of the matrix metalloproteinase gene familyQ28293228
Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectivelyQ28306053
Expression of three membrane-type matrix metalloproteinases (MT-MMPs) in rat vascular smooth muscle cells and characterization of MT3-MMPs with and without transmembrane domainQ28307087
Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active speciesQ28367213
The membrane-anchored MMP inhibitor RECK is a key regulator of extracellular matrix integrity and angiogenesisQ28504785
Inactivating mutation of the mouse tissue inhibitor of metalloproteinases-2(Timp-2) gene alters proMMP-2 activationQ28509009
TIMP-2 is required for efficient activation of proMMP-2 in vivoQ28512714
Heparan sulfate proteoglycans as extracellular docking molecules for matrilysin (matrix metalloproteinase 7)Q28564762
Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantationQ28587897
The proprotein convertasesQ28609903
Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domainQ28610274
Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 releaseQ28611028
Membrane-type matrix metalloproteinases 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinasesQ28611036
Matrix metalloproteinase degradation of extracellular matrix: biological consequencesQ28611041
Activation of membrane-type matrix metalloproteinase 3 zymogen by the proprotein convertase furin in the trans-Golgi networkQ28616788
Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloproteaseQ28618841
Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activityQ28618997
The TIMP2 membrane type 1 metalloproteinase "receptor" regulates the concentration and efficient activation of progelatinase A. A kinetic studyQ28619177
Matrix metalloproteinases: effectors of development and normal physiologyQ28679038
New functions for the matrix metalloproteinases in cancer progressionQ29547738
Matrix metalloproteinases: a reviewQ29620220
How matrix metalloproteinases regulate cell behaviorQ29620360
Identification of substrate sequences for membrane type-1 matrix metalloproteinase using bacteriophage peptide display libraryQ30641764
Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysinsQ34479986
Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24.Q34486182
Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomasQ34497741
Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.Q34733220
Invasiveness of hepatocellular carcinoma cell lines: contribution of membrane-type 1 matrix metalloproteinaseQ34786196
Differential expression and origin of membrane-type 1 and 2 matrix metalloproteinases (MT-MMPs) in association with MMP2 activation in injured human liversQ35753435
Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytesQ35765296
MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cellsQ59571869
Collagen-induced proMMP-2 activation by MT1-MMP in human dermal fibroblasts and the possible role of ?2?1 integrinsQ59591366
Tissue Inhibitor of Matrix Metalloproteinase-2 Regulates Matrix Metalloproteinase-2 Activation by Modulation of Membrane-type 1 Matrix Metalloproteinase Activity in High and Low Invasive Melanoma Cell LinesQ59591367
Role of MT-MMPs and MMP-2 in pancreatic cancer progressionQ60609532
Down-regulation of vascular endothelial growth factor by tissue inhibitor of metalloproteinase-2: effect on in vivo mammary tumor growth and angiogenesisQ64379930
Soluble laminin and arginine-glycine-aspartic acid containing peptides differentially regulate type IV collagenase messenger RNA, activation, and localization in testicular cell cultureQ68272557
Assignment of the human membrane-type matrix metalloproteinase (MMP14) gene to 14q11-q12 by in situ hybridizationQ70807863
Inhibition of matrix metalloproteinase activity inhibits smooth muscle cell migration but not neointimal thickening after arterial injuryQ71006325
MT-MMP expression and localisation in human lung and breast cancersQ71116140
Cell surface binding and activation of gelatinase A induced by expression of membrane-type-1-matrix metalloproteinase (MT1-MMP)Q71118438
Activation of 72-kDa type IV collagenase/gelatinase by normal fibroblasts in collagen lattices is mediated by integrin receptors but is not related to lattice contractionQ71637835
Thrombin induces the activation of progelatinase A in vascular endothelial cells. Physiologic regulation of angiogenesisQ71743251
Activation of the precursor of gelatinase A/72 kDa type IV collagenase/MMP-2 in lung carcinomas correlates with the expression of membrane-type matrix metalloproteinase (MT-MMP) and with lymph node metastasisQ71820200
Dual over-expression pattern of membrane-type metalloproteinase-1 in cancer and stromal cells in human gastrointestinal carcinoma revealed by in situ hybridization and immunoelectron microscopyQ71821481
Membrane type matrix metalloproteinase 1 activates pro-gelatinase A without furin cleavage of the N-terminal domainQ71825162
Expression of membrane-type matrix metalloproteinase in human gastric carcinomasQ71887264
Basement Membrane Collagen: Degradation by Migrating Endothelial CellsQ72699515
The distribution of epidermal growth factor binding sites in the developing mouse palateQ72734558
MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnoverQ73082300
Proteolytic activation of the precursor of membrane type 1 matrix metalloproteinase by human plasmin. A possible cell surface activatorQ73082573
Matrix mattersQ73085842
Characterization of stromelysin 1 (MMP-3), matrilysin (MMP-7), and membrane type 1 matrix metalloproteinase (MT1-MMP) derived fibrin(ogen) fragments D-dimer and D-like monomer: NH2-terminal sequences of late-stage digest fragmentsQ73101332
Gelatinase A activation is regulated by the organization of the polymerized actin cytoskeletonQ73119529
Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP-8) to stability and collagenolytic activity by alanine scanning mutagenesisQ73204885
Matrix metalloproteinase homologues from Arabidopsis thaliana. Expression and activityQ73212038
Thrombin promotes activation of matrix metalloproteinase-2 produced by cultured vascular smooth muscle cellsQ73221005
Remodeling of carotid artery is associated with increased expression of matrix metalloproteinases in mouse blood flow cessation modelQ73265468
Type IV collagen induces matrix metalloproteinase 2 activation in HT1080 fibrosarcoma cellsQ73286853
Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP.Q30656169
Expression and localization of transcripts of MT5-MMP and its related MMP in the ovary of the medaka fish Oryzias latipesQ30660273
Identification of a novel class of small-molecule antiangiogenic agents through the screening of combinatorial libraries which function by inhibiting the binding and localization of proteinase MMP2 to integrin alpha(V)beta(3).Q30663571
Determination of protease cleavage site motifs using mixture-based oriented peptide librariesQ30702360
Tumor targeting with a selective gelatinase inhibitorQ30747366
Membrane type 1 matrix metalloproteinase and gelatinase A synergistically degrade type 1 collagen in a cell modelQ32148378
Shedding of membrane type 1 matrix metalloproteinase in a human breast carcinoma cell lineQ33179117
Matrix metalloproteinases: a tail of a frog that became a princeQ33337157
Membrane-type matrix metalloproteinasesQ33586502
Regulation of matrix metalloproteinase expression in tumor invasion.Q33605726
Matrix metalloproteinases in angiogenesis: a moving target for therapeutic interventionQ33606833
Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applicationsQ33692926
Extracellular matrix degradation by metalloproteinases and central nervous system diseasesQ33737455
Proteolysis and cell migration: creating a path?Q33744936
Extracellular matrix-driven matrix metalloproteinase production in endothelial cells: implications for angiogenesisQ33782645
The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesisQ33783677
Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5.Q33843796
Membrane type 4 matrix metalloproteinase (MT4-MMP, MMP-17) is a glycosylphosphatidylinositol-anchored proteinase.Q33880837
Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor.Q33885867
Changing concepts of atherogenesisQ33890391
Myocardial matrix degradation and metalloproteinase activation in the failing heart: a potential therapeutic targetQ33895469
Membrane type 4 matrix metalloproteinase (MMP17) has tumor necrosis factor-alpha convertase activity but does not activate pro-MMP2.Q33900860
Cysteine array matrix metalloproteinase (CA-MMP)/MMP-23 is a type II transmembrane matrix metalloproteinase regulated by a single cleavage for both secretion and activationQ33914246
Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25).Q33935969
Subcellular distribution and cytokine- and chemokine-regulated secretion of leukolysin/MT6-MMP/MMP-25 in neutrophilsQ33941026
Furin inhibition results in absent or decreased invasiveness and tumorigenicity of human cancer cellsQ33943172
Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosisQ33949968
Tumor angiogenesis: thrombin and metalloproteinases in focusQ33966003
Matrix metalloproteinases in tumor invasion and metastasisQ34136635
Critical appraisal of the use of matrix metalloproteinase inhibitors in cancer treatmentQ34293595
The soluble catalytic domain of membrane type 1 matrix metalloproteinase cleaves the propeptide of progelatinase A and initiates autoproteolytic activation. Regulation by TIMP-2 and TIMP-3.Q34384684
Cellular strategies for proteolytic targeting during migration and invasionQ34395533
Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysemaQ34457903
Tumorigenic potential of extracellular matrix metalloproteinase inducerQ35842240
Activity of type IV collagenases in benign and malignant breast diseaseQ35976755
Cyclooxygenase-2 expression in human colon cancer cells increases metastatic potentialQ36085224
Membrane-type 1 matrix metalloprotease (MT1-MMP) enables invasive migration of glioma cells in central nervous system white matterQ36255730
Expression of matrix metalloproteinases during rat skin wound healing: evidence that membrane type-1 matrix metalloproteinase is a stromal activator of pro-gelatinase AQ36274038
TGF-beta3-induced palatogenesis requires matrix metalloproteinasesQ36284069
Regulation of cell invasion and morphogenesis in a three-dimensional type I collagen matrix by membrane-type matrix metalloproteinases 1, 2, and 3.Q36328263
Matrix metalloproteinases (MMPs) regulate fibrin-invasive activity via MT1-MMP-dependent and -independent processesQ36369835
Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivoQ36376907
A regulatory cascade involving retinoic acid, Cbfa1, and matrix metalloproteinases is coupled to the development of a process of perichondrial invasion and osteogenic differentiation during bone formationQ36381389
Cloning of a human gene potentially encoding a novel matrix metalloproteinase having a C-terminal transmembrane domainQ36700680
Isolation of a mouse MT2-MMP gene from a lung cDNA library and identification of its productQ36847047
Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarctionQ37527656
Calreticulin is directly involved in anti-alpha3 integrin antibody-mediated secretion and activation of matrix metalloprotease-2.Q38301395
Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic miceQ38525299
Membrane-type 1 matrix metalloproteinase-mediated progelatinase A activation in non-tumorigenic and tumorigenic human keratinocytesQ38785129
Proteinases in cardiovascular aneurysms and rupture: targets for therapy?Q40365142
Matrix metalloproteinases and cardiovascular diseaseQ40410789
Structural features of a superfamily of zinc-endopeptidases: the metzincinsQ40428339
Complex pattern of membrane type 1 matrix metalloproteinase shedding. Regulation by autocatalytic cells surface inactivation of active enzymeQ40732890
Oligomerization through hemopexin and cytoplasmic domains regulates the activity and turnover of membrane-type 1 matrix metalloproteinaseQ40758551
Cellular activation of MMP-2 (gelatinase A) by MT2-MMP occurs via a TIMP-2-independent pathwayQ40777137
Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1.Q40778640
Regulation of the alpha-secretase ADAM10 by its prodomain and proprotein convertases.Q40789097
Shedding of membrane type matrix metalloproteinase 5 by a furin-type convertase: a potential mechanism for down-regulationQ40790178
Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migrationQ40802553
The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domainQ40818712
Down-Regulation of MT1-MMP expression by the alpha3 chain of type IV collagen inhibits bronchial tumor cell line invasionQ40822760
Elevated expression of membrane type 1 metalloproteinase (MT1-MMP) in reactive astrocytes following neurodegeneration in mouse central nervous systemQ40852287
Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.Q40853467
In vivo migration of transplanted myoblasts requires matrix metalloproteinase activity.Q40868335
Hepatocyte growth factor enhances MMP activity in human endothelial cellsQ40873055
Binding of active (57 kDa) membrane type 1-matrix metalloproteinase (MT1-MMP) to tissue inhibitor of metalloproteinase (TIMP)-2 regulates MT1-MMP processing and pro-MMP-2 activation.Q40886684
Structural analysis and promoter characterization of the human membrane-type matrix metalloproteinase-1 (MT1-MMP) gene.Q40893331
Activation of matrix metalloproteinase-2 in human breast cancer cells overexpressing cyclooxygenase-1 or -2.Q40916497
Overview of expression of matrix metalloproteinases (MMP-17, MMP-18, and MMP-20) in cultured human cellsQ40947666
Proteolytic remodeling of extracellular matrixQ40952583
Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): mechanisms that control enzyme activity, transcription, and mRNA stabilityQ40955756
Regulation of matrix metalloproteinase-2 (gelatinase A, MMP-2), membrane-type matrix metalloproteinase-1 (MT1-MMP) and tissue inhibitor of metalloproteinases-2 (TIMP-2) expression by elastin-derived peptides in human HT-1080 fibrosarcoma cell lineQ40984834
Proteolytic processing of membrane-type-1 matrix metalloproteinase is associated with gelatinase A activation at the cell surfaceQ41013800
Role of tissue inhibitor of metalloproteinases-2 (TIMP-2) in regulation of pro-gelatinase A activation catalyzed by membrane-type matrix metalloproteinase-1 (MT1-MMP) in human cancer cellsQ41020537
Expression and localization of membrane type matrix metalloproteinase-1 (MT1-MMP) in trophoblast cells of cultured mouse blastocysts and ectoplacental conesQ41063211
c-Ras is required for the activation of the matrix metalloproteinases by concanavalin A in 3Y1 cellsQ41116569
Cell-cell contact down-regulates expression of membrane type metalloproteinase-1 (MT1-MMP) in a mouse mammary gland epithelial cell lineQ41128912
Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromoleculesQ41133261
Membrane-type matrix metalloproteinases (MT-MMPs) in tumor metastasisQ41178387
Regulation of membrane-type matrix metalloproteinase-1 expression by growth factors and phorbol 12-myristate 13-acetate.Q41184688
The C-terminal region of membrane type matrix metalloproteinase is a functional transmembrane domain required for pro-gelatinase A activationQ41380842
Secretion of gelatinases and tissue inhibitors of metalloproteinases by human lung cancer cell lines and revertant cell lines: not an invariant correlation with metastasisQ41602595
Affinity of integrins for damaged extracellular matrix: alpha v beta 3 binds to denatured collagen type I through RGD sitesQ41639991
Inflammatory cytokines and oxidized low density lipoproteins increase endothelial cell expression of membrane type 1-matrix metalloproteinaseQ41646524
Matrix metalloproteinases and coronary artery disease: a novel therapeutic targetQ41722548
Extraction of type-IV collagenase/gelatinase from plasma membranes of human cancer cellsQ41730868
Cellular activation of mesangial gelatinase A by cytochalasin D is accompanied by enhanced mRNA expression of both gelatinase A and its membrane-associated gelatinase A activator (MT-MMP).Q41868757
The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinasesQ41943469
Ligation of alpha4ss1 integrin on human intestinal mucosal mesenchymal cells selectively Up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotypeQ41943857
Expression and tissue localization of membrane-type 1, 2, and 3 matrix metalloproteinases in human astrocytic tumorsQ42048997
Analysis of tissue inhibitor of metalloproteinases-2 effect on pro-matrix metalloproteinase-2 activation by membrane-type 1 matrix metalloproteinase using baculovirus/insect-cell expression systemQ42158569
Immunohistochemical detection of membrane-type-1-matrix metalloproteinase in colorectal carcinomaQ42279639
Enhancement of membrane-type 1-matrix metalloproteinase (MT1-MMP) production and sequential activation of progelatinase A on human squamous carcinoma cells co-cultured with human dermal fibroblastsQ42279993
Membrane type 1-matrix metalloproteinase (MT1-MMP) and MMP-2 immunolocalization in human prostate: change in cellular localization associated with high-grade prostatic intraepithelial neoplasiaQ42482174
Degradation of type IV collagen by matrix metalloproteinases is an important step in the epithelial-mesenchymal transformation of the endocardial cushionsQ42495701
Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptorQ42653828
A plasma membrane-associated component of ovarian adenocarcinoma cells enhances the catalytic efficiency of matrix metalloproteinase-2.Q42806172
Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cellsQ42855929
Localization of membrane-type 1 matrix metalloproteinase in caveolae membrane domainsQ42998517
Tissue inhibitor of metalloproteinases-2 (TIMP-2) suppresses TKR-growth factor signaling independent of metalloproteinase inhibitionQ43508547
Perivascular cells regulate endothelial membrane type-1 matrix metalloproteinase activityQ43636531
Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodelingQ43670946
Insight into the complex and dynamic process of activation of matrix metalloproteinasesQ43677712
A conserved sequence within the propeptide domain of membrane type 1 matrix metalloproteinase is critical for function as an intramolecular chaperoneQ43796757
An alternative processing of integrin alpha(v) subunit in tumor cells by membrane type-1 matrix metalloproteinaseQ43821714
MT1-MMP-dependent and -independent regulation of gelatinase A activation in long-term, ascorbate-treated fibroblast cultures: regulation by fibrillar collagenQ43845368
Rapid trafficking of membrane type 1-matrix metalloproteinase to the cell surface regulates progelatinase a activation.Q44248212
Cancer cell invasion and metastasisQ44379278
MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cellsQ46095406
Structural and enzymatic characterization of Drosophila Dm2-MMP, a membrane-bound matrix metalloproteinase with tissue-specific expression.Q47071821
The involvement of the fibronectin type II-like modules of human gelatinase A in cell surface localization and activationQ47761007
Function of the plasminogen/plasmin and matrix metalloproteinase systems after vascular injury in mice with targeted inactivation of fibrinolytic system genesQ47810211
Dm1-MMP, a matrix metalloproteinase from Drosophila with a potential role in extracellular matrix remodeling during neural developmentQ47833577
Expression of membrane type 1 matrix metalloproteinase (MT1-MMP) in A2058 melanoma cells is associated with MMP-2 activation and increased tumor growth and vascularizationQ47848846
Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domainQ47850733
Immunological characterization of cell-surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblastsQ47878293
Expression of membrane-type matrix metalloproteinase-1 in human pancreatic adenocarcinomasQ47880855
Stretch-induced membrane type matrix metalloproteinase and tissue plasminogen activator in cardiac fibroblast cellsQ47903075
Activation of MMP-2 by human GCT23 giant cell tumour cells induced by osteopontin, bone sialoprotein and GRGDSP peptides is RGD and cell shape change dependent.Q47930008
Expression of membrane-type matrix metalloproteinase in rabbit neointimal tissue and its correlation with matrix-metalloproteinase-2 activationQ48040095
The matrix metalloproteinase-14 (MMP-14) gene is structurally distinct from other MMP genes and is co-expressed with the TIMP-2 gene during mouse embryogenesisQ48043742
Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase.Q48159635
Regulation of matrix metalloproteinase-2 (MMP-2) by hepatocyte growth factor/scatter factor (HGF/SF) in human glioma cells: HGF/SF enhances MMP-2 expression and activation accompanying up-regulation of membrane type-1 MMP.Q48173251
Membrane-type 1 matrix metalloproteinase mRNA expression in colorectal cancerQ48561841
Metastatic mouse melanoma cells release collagen-gelatin degrading metalloproteinases as components of shed membrane vesicles.Q51197764
Diminished matrix metalloproteinase 2 (MMP-2) in ectomesenchyme-derived tissues of the Patch mutant mouse: regulation of MMP-2 by PDGF and effects on mesenchymal cell migration.Q52175351
Cloning and developmental expression of a membrane-type matrix metalloproteinase from chicken.Q52199399
Collagen and elastin degradation by matrix metalloproteinases and tissue inhibitors of matrix metalloproteinase in aortic dissection.Q52539773
Rapid activation of matrix metalloproteinase-2 by glioma cells occurs through a posttranslational MT1-MMP-dependent mechanism.Q52541045
White matter microglia produce membrane-type matrix metalloprotease, an activator of gelatinase A, in human brain tissues.Q53210682
Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion.Q55474490
Expression of emmprin (CD147), a cell surface inducer of matrix metalloproteinases, in normal human brain and gliomas.Q55475249
Functional activation of integrin alpha V beta 3 in tumor cells expressing membrane-type 1 matrix metalloproteinaseQ57167800
Distinct roles for matrix metalloproteinase-2 and alpha4 integrin in autoimmune T cell extravasation and residency in brain parenchyma during experimental autoimmune encephalomyelitisQ74340538
Elevated cyclic AMP suppresses ConA-induced MT1-MMP expression in MDA-MB-231 human breast cancer cellsQ74350293
Membrane-type matrix metalloproteinase-1(MT1-MTP) gene is overexpressed in highly invasive hepatocellular carcinomasQ74351891
Inhibition of membrane-type 1 matrix metalloproteinase by hydroxamate inhibitors: an examination of the subsite pocketQ74457179
CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migrationQ74528310
Activation of the extracellular signal-regulated protein kinase (ERK) cascade by membrane-type-1 matrix metalloproteinase (MT1-MMP)Q77086987
Vascular extracellular matrix remodeling in cerebral aneurysmsQ77180718
Plasma membrane-bound tissue inhibitor of metalloproteinases (TIMP)-2 specifically inhibits matrix metalloproteinase 2 (gelatinase A) activated on the cell surfaceQ77228964
Ventilator-induced lung injury upregulates and activates gelatinases and EMMPRIN: attenuation by the synthetic matrix metalloproteinase inhibitor, Prinomastat (AG3340)Q77300084
Matrix metalloproteases: variations on a themeQ77455726
Membrane type 1-matrix metalloproteinase is involved in the formation of hepatocyte growth factor/scatter factor-induced branching tubules in madin-darby canine kidney epithelial cellsQ77472189
Membrane-type metalloproteinases in tumor invasionQ77635815
The interrelationship of alpha4 integrin and matrix metalloproteinase-2 in the pathogenesis of experimental autoimmune encephalomyelitisQ77639447
Two-step sandwich enzyme immunoassay using monoclonal antibodies for detection of soluble and membrane-associated human membrane type 1-matrix metalloproteinaseQ77645044
SPARC/osteonectin induces matrix metalloproteinase 2 activation in human breast cancer cell linesQ77670137
Soluble latent membrane-type 1 matrix metalloprotease secreted by human mesangial cells is activated by urokinaseQ77682531
MMP-2 and TIMP-2 expression correlates with poor prognosis in cervical carcinoma--a clinicopathologic study using immunohistochemistry and mRNA in situ hybridizationQ77874142
New collagenolytic enzymes/cascade identified at the pannus-hard tissue junction in rheumatoid arthritis: destruction from aboveQ77922271
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human papillary thyroid carcinomasQ77931928
Presence of high levels of MT1-MMP protein in fibroblastic cells of human invasive carcinomasQ77947962
Expression of gelatinase A and its activator MT1-MMP in the inflammatory periprosthetic response to polyethyleneQ77953566
Regulation of gelatinases in human airway smooth muscle cells: mechanism of progelatinase A activationQ78009358
Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase in endotheliumQ78069867
Expression of messenger RNAs for membrane-type 1, 2, and 3 matrix metalloproteinases in human renal cell carcinomasQ78161400
Extracellular matrix metalloproteinase 2 levels are regulated by the low density lipoprotein-related scavenger receptor and thrombospondin 2Q73288795
Progesterone inhibits activation of latent matrix metalloproteinase (MMP)-2 by membrane-type 1 MMP: enzymes coordinately expressed in human endometriumQ73302075
MMP-2 colocalizes with caveolae on the surface of endothelial cellsQ73306221
Hypercholesterolemia causes mechanical weakening of rabbit atheroma : local collagen loss as a prerequisite of plaque ruptureQ73333660
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomasQ73352931
Activation of gelatinase A (72-kDa type IV collagenase) induced by monensin in normal human fibroblastsQ73381249
Human membrane type-2 matrix metalloproteinase is defective in cell-associated activation of progelatinase AQ73445365
Neutrophil-derived serine proteinases enhance membrane type-1 matrix metalloproteinase-dependent tumor cell invasionQ73474651
Analysis of MT1-MMP and MMP2 expression in human gastric cancersQ73507947
Heat shock-mediated transient increase in intracellular 3',5'-cyclic AMP results in tumor specific suppression of membrane type 1-matrix metalloproteinase production and progelatinase A activationQ73581114
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: implications for lymph node metastasisQ73581133
Membrane type 1 matrix metalloproteinase-associated degradation of tissue inhibitor of metalloproteinase 2 in human tumor cell linesQ73643352
Three-dimensional collagen matrices induce delayed but sustained activation of gelatinase A in human endothelial cells via MT1-MMPQ73720926
All-trans-retinoic acid decreases vein graft intimal hyperplasia and matrix metalloproteinase activity in vivoQ73739972
Thrombin receptor-mediated increase of two matrix metalloproteinases, MMP-1 and MMP-3, in human endothelial cellsQ73832884
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in rheumatoid synoviumQ73833090
Rac1 mediates type I collagen-dependent MMP-2 activation. role in cell invasion across collagen barrierQ73842972
Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cellsQ73855117
Tyrosine phosphorylation mediates ConA-induced membrane type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in MDA-MB-231 human breast carcinoma cellsQ73883829
Atherosclerotic arterial remodeling and the localization of macrophages and matrix metalloproteases 1, 2 and 9 in the human coronary arteryQ73901878
Differential expression pattern of membrane-type matrix metalloproteinases in rheumatoid arthritisQ73904628
Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progressionQ73949261
Macrophage-derived MT1-MMP and increased MMP-2 activity are associated with glomerular damage in crescentic glomerulonephritisQ73949287
cAMP involvement in the expression of MMP-2 and MT-MMP1 metalloproteinases in human endothelial cellsQ73965958
The propeptide domain of membrane type 1-matrix metalloproteinase acts as an intramolecular chaperone when expressed in trans with the mature sequence in COS-1 cellsQ73977875
Intact vitronectin induces matrix metalloproteinase-2 and tissue inhibitor of metalloproteinases-2 expression and enhanced cellular invasion by melanoma cellsQ73995916
Increased expression of membrane-type matrix metalloproteinase and preferential localization of matrix metalloproteinase-2 to the neointima of balloon-injured rat carotid arteriesQ74093557
Matrix metalloproteinases and collagen ultrastructure in moderate myocardial ischemia and reperfusion in vivoQ74103792
Membrane type-1 matrix metalloprotease and stromelysin-3 cleave more efficiently synthetic substrates containing unusual amino acids in their P1' positionsQ74105851
Production of membrane-type matrix metalloproteinase-1 (MT-MMP-1) in early human placenta. A possible role in placental implantation?Q74106703
Don't mess with the matrixQ74115790
Three-dimensional type I collagen lattices induce coordinate expression of matrix metalloproteinases MT1-MMP and MMP-2 in microvascular endothelial cellsQ74129035
Membrane type 1-matrix metalloproteinase expression is regulated by E-cadherin through the suppression of mitogen-activated protein kinase cascadeQ74148127
MT1-MMP on the cell surface causes focal degradation of gelatin filmsQ74191580
Furin and membrane type-1 metalloproteinase mRNA levels and activation of metalloproteinase-2 are associated with arterial remodelingQ74214731
Matrix metalloproteinases and tissue inhibitor of metalloproteinase-2 in fetal rabbit lungQ74219130
MT1-MMP and MMP-2 mRNA expression in human ovarian tumors: possible implications for the role of desmoplastic fibroblastsQ74268786
Calmodulin antagonists increase the expression of membrane-type-1 matrix metalloproteinase in human uterine cervical fibroblastsQ74279403
Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: conversion of prothrombin to thrombin results in progelatinase A activation and cell proliferationQ74292354
Reduced angiogenesis and tumor progression in gelatinase A-deficient miceQ74309789
Clinical significance of expression of membrane type 1 matrix metalloproteinase and matrix metalloproteinase-2 in human head and neck squamous cell carcinomaQ74314745
Localization of MT1-MMP, TIMP-1, TIMP-2, and TIMP-3 messenger RNA in normal, hyperplastic, and neoplastic endometrium. Enhanced expression by endometrial adenocarcinomas is associated with low differentiationQ74318565
P407language of work or nameEnglishQ1860
P304page(s)1-74
P577publication date2003-01-01
P1433published inCurrent Topics in Developmental BiologyQ15745419
P1476titleMembrane type-matrix metalloproteinases (MT-MMP)
P478volume54

Reverse relations

cites work (P2860)
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