Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo

scholarly article

Expression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2006PNAS..10316930K
P356DOI10.1073/PNAS.0604902103
P932PMC publication ID1629449
P698PubMed publication ID17077140
P5875ResearchGate publication ID6719696

P50authorJohn DickQ6229356
Jeremy A. SquireQ39802515
P2093author name stringD L Barber
J A Kennedy
J Bayani
F Barabé
B J Patterson
P2860cites workThe Janus kinases (Jaks)Q21194856
Retroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cellsQ24669651
Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivoQ28210990
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia veraQ28241887
The t(8;9)(p22;p24) is a recurrent abnormality in chronic and acute leukemia that fuses PCM1 to JAK2Q28243103
Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemiaQ28250886
A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemiaQ28253771
PCM1-JAK2 fusion in myeloproliferative disorders and acute erythroid leukemia with t(8;9) translocationQ28263004
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosisQ29614337
A gain-of-function mutation of JAK2 in myeloproliferative disordersQ29618851
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disordersQ29618853
JAK2V617F expression in murine hematopoietic cells leads to MPD mimicking human PV with secondary myelofibrosis.Q33371084
Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genesQ33889476
Dissociation of telomerase activity and telomere length maintenance in primitive human hematopoietic cellsQ34063522
Expression of a homodimeric type I cytokine receptor is required for JAK2V617F-mediated transformationQ34245259
Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant modelQ35849674
A BCR-JAK2 fusion gene as the result of a t(9;22)(p24;q11.2) translocation in a patient with a clinically typical chronic myeloid leukemiaQ36185370
Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiationQ36402468
TEL-JAK2 constitutively activates the extracellular signal-regulated kinase (ERK), stress-activated protein/Jun kinase (SAPK/JNK), and p38 signaling pathwaysQ40714424
TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathwayQ40795252
Transforming properties of chimeric TEL-JAK proteins in Ba/F3 cellsQ40895260
Fusion of the ets transcription factor TEL to Jak2 results in constitutive Jak-Stat signalingQ40949830
Modulation of p210(BCR-ABL) activity in transduced primary human hematopoietic cells controls lineage programmingQ43966206
Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cellsQ44471784
Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera.Q44854570
AML1/ETO promotes the maintenance of early hematopoietic progenitors in NOD/SCID mice but does not abrogate their lineage specific differentiationQ45204173
BCR-ABL-transduced human cord blood cells produce abnormal populations in immunodeficient miceQ45240581
Engraftment of immune-deficient mice with primitive hematopoietic cells from beta-thalassemia and sickle cell anemia patients: implications for evaluating human gene therapy protocols.Q45869160
Distinct classes of human stem cells that differ in proliferative and self-renewal potentialQ45873643
The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion geneQ46643222
Myelodysplastic/myeloproliferative disease with erythropoietic hyperplasia (erythroid preleukemia) and the unique translocation (8;9)(p23;p24): first description of a caseQ46753958
Letter: Bone-marrow responses in polycythemia veraQ47871256
Myeloproliferative disorders carrying the t(8;9) (PCM1-JAK2) translocation.Q53630624
Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2Q57054898
Human short-term repopulating stem cells are efficiently detected following intrafemoral transplantation into NOD/SCID recipients depleted of CD122+ cellsQ59599864
Opinion: Comparative biology of mouse versus human cells: modelling human cancer in miceQ75312804
Prominent role of TGF-beta 1 in thrombopoietin-induced myelofibrosis in miceQ78410479
A t(8;9) translocation with PCM1-JAK2 fusion in a patient with T-cell lymphomaQ82314612
Constitutive activation of STAT5 and Bcl-xL overexpression can induce endogenous erythroid colony formation in human primary cellsQ83310312
P433issue45
P407language of work or nameEnglishQ1860
P921main subjecterythropoietinQ218706
myelofibrosisQ1752571
P304page(s)16930-16935
P577publication date2006-10-31
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleExpression of TEL-JAK2 in primary human hematopoietic cells drives erythropoietin-independent erythropoiesis and induces myelofibrosis in vivo
P478volume103

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cites work (P2860)
Q36079807Context Matters: Distinct Disease Outcomes as a Result of Crebbp Hemizygosity in Different Mouse Bone Marrow Compartments
Q38598868Cytokine Signaling in Tumor Progression
Q38999178Dominant-negative Ikaros cooperates with BCR-ABL1 to induce human acute myeloid leukemia in xenografts
Q37237331Investigating human leukemogenesis: from cell lines to in vivo models of human leukemia
Q36285745JAK Kinases in Health and Disease: An Update
Q33378737JAK and MPL mutations in myeloid malignancies
Q34641224JAK/STAT signaling in hematological malignancies.
Q21285040JAK2 Inhibition: Reviewing a New Therapeutical Option in Myeloproliferative Neoplasms
Q24322021Janus kinases in immune cell signaling
Q37379320Molecular drug targets in myeloproliferative neoplasms: mutant ABL1, JAK2, MPL, KIT, PDGFRA, PDGFRB and FGFR1.
Q33753094Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis
Q54633559Pathology of the bone marrow and spleen in a case of myelodysplastic/myeloproliferative neoplasm associated with t(8;9)(p22;p24) involving PCM1 and JAK2 genes
Q42133453Physiological Jak2V617F expression causes a lethal myeloproliferative neoplasm with differential effects on hematopoietic stem and progenitor cells

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