BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia.

scientific article

BCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BCMD.2015.01.001
P932PMC publication ID4341902
P698PubMed publication ID25703683
P5875ResearchGate publication ID272027874

P50authorPaola SebastianiQ7132103
Martin H SteinbergQ37380250
Lindsay A. FarrerQ37380266
Heather L EdwardQ58179715
P2093author name stringS Wang
J J Farrell
C T Baldwin
P K Patra
H Bae
A K Al-Ali
H Shappell
D Ngo
A Alsultan
A Alsuliman
A M Al-Rubaish
D H K Chui
F Al-Muhanna
J N Milton
V Vathipadiekal
Z Naserullah
P2860cites workGenome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemiaQ24652468
Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene clusterQ33706399
Sickle cell disease in Saudi Arabia: the phenotype in adults with the Arab-Indian haplotype is not benign.Q33888761
Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patientsQ34165031
Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotypeQ34610322
A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.Q34674466
Ancestry of African Americans with sickle cell diseaseQ35049741
A functional element necessary for fetal hemoglobin silencingQ35217485
Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypesQ35558802
Fetal hemoglobin in sickle cell anemia: molecular characterization of the unusually high fetal hemoglobin phenotype in African Americans.Q35827878
Genetic modifiers of sickle cell diseaseQ36035471
Sparing effect of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin S at physiologic ligand saturationsQ36333394
DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell diseaseQ36800496
Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variationQ37088889
Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencingQ37102932
Structural bases of the inhibitory effects of hemoglobin F and hemoglobin A2 on the polymerization of hemoglobin SQ37314123
An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level.Q39081873
Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.Q39908659
Natural history of sickle cell anemia in Saudi Arabs. A study of 270 subjectsQ40108760
The cooperative study of sickle cell disease: review of study design and objectives.Q40343580
Geographical survey of beta S-globin gene haplotypes: evidence for an independent Asian origin of the sickle-cell mutation.Q40591317
BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathiesQ41827242
Meta-analysis of 2040 sickle cell anemia patients: BCL11A and HBS1L-MYB are the major modifiers of HbF in African AmericansQ42322732
A functional promoter polymorphism of the δ-globin gene is a specific marker of the Arab-Indian haplotypeQ44362006
Fetal hemoglobin in sickle cell anemia: Saudi patients from the Southwestern province have similar HBB haplotypes but higher HbF levels than African AmericansQ46327662
The hematologic characteristics of sickle cell anemia bearing the Bantu haplotype: the relationship between G gamma and HbF levelQ46384824
Hematologically and genetically distinct forms of sickle cell anemia in Africa. The Senegal type and the Benin typeQ46597587
Haplotypes in tribal Indians bearing the sickle gene: evidence for the unicentric origin of the beta S mutation and the unicentric origin of the tribal populations of IndiaQ46837730
Estimation and tests of haplotype-environment interaction when linkage phase is ambiguousQ47724047
Amplification-refractory mutation system (ARMS) analysis of point mutations.Q54535992
cMYB is involved in the regulation of fetal hemoglobin production in adults.Q54591078
Fetal haemoglobin production and the sickle gene in the oases of Eastern Saudi ArabiaQ67447872
Variable phenotypes of sickle cell disease in India with the Arab-Indian haplotypeQ87611221
Benign sickle-cell anaemiaQ93730107
P433issue3
P921main subjectsickle-cell diseaseQ185034
P304page(s)224-230
P577publication date2015-01-30
P1433published inBlood Cells, Molecules and DiseasesQ15758051
P1476titleBCL11A enhancer haplotypes and fetal hemoglobin in sickle cell anemia
P478volume54

Reverse relations

cites work (P2860)
Q42711553A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia
Q36191670Association between Variants at BCL11A Erythroid-Specific Enhancer and Fetal Hemoglobin Levels among Sickle Cell Disease Patients in Cameroon: Implications for Future Therapeutic Interventions
Q90619256BCL11A rs1427407 Genotypes in Sickle Cell Anemia Patients Undergo to Stroke Problems in Sudan
Q88101760Biological impact of α genes, β haplotypes, and G6PD activity in sickle cell anemia at baseline and with hydroxyurea
Q97542138Combinatorial and statistical prediction of gene expression from haplotype sequence
Q47147613Concise Review: Epigenetic Regulation of Hematopoiesis: Biological Insights and Therapeutic Applications
Q38253721Demystifying the secret mission of enhancers: linking distal regulatory elements to target genes
Q41957583Existence of HbF Enhancer Haplotypes at HBS1L-MYB Intergenic Region in Transfusion-Dependent Saudi β-Thalassemia Patients.
Q39453785Fetal hemoglobin in sickle cell anemia: The Arab-Indian haplotype and new therapeutic agents
Q51080070Genetic Variants at BCL11A and HBS1L-MYB loci Influence Hb F Levels in Chinese Zhuang β-Thalassemia Intermedia Patients.
Q26799214Genomic approaches to identifying targets for treating β hemoglobinopathies
Q41959356Homozygosity for a haplotype in the HBG2-OR51B4 region is exclusive to Arab-Indian haplotype sickle cell anemia
Q37107201Original Research: A case-control genome-wide association study identifies genetic modifiers of fetal hemoglobin in sickle cell disease
Q45874809Pharmacological and molecular approaches for the treatment of β-hemoglobin disorders.
Q40278751Protective BCL11A and HBS1L-MYB polymorphisms in a cohort of 102 Congolese patients suffering from sickle cell anemia.
Q35996218Pulmonary function indices in children with sickle cell anemia in Enugu, south-east Nigeria
Q53174215Reduced rate of sickle-related complications in Brazilian patients carrying HbF-promoting alleles at the BCL11A and HMIP-2 loci.

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