Conformational changes in the P site and mRNA entry channel evoked by AUG recognition in yeast translation preinitiation complexes

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Conformational changes in the P site and mRNA entry channel evoked by AUG recognition in yeast translation preinitiation complexes is …
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scholarly articleQ13442814

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P356DOI10.1093/NAR/GKV028
P8608Fatcat IDrelease_caehipbxzvfhrb7dzwankoxjhe
P932PMC publication ID4344491
P698PubMed publication ID25670678
P5875ResearchGate publication ID272190958

P50authorAdesh K SainiQ56670325
P2093author name stringFan Zhang
Alan G Hinnebusch
Byung-Sik Shin
Jagpreet Nanda
P2860cites workStructure of the mammalian ribosomal 43S preinitiation complex bound to the scanning factor DHX29Q24293558
Domains of eIF1A that mediate binding to eIF2, eIF3 and eIF5B and promote ternary complex recruitment in vivoQ24540322
The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codonQ24630664
The eIF1A solution structure reveals a large RNA-binding surface important for scanning functionQ27621444
Comprehensive Molecular Structure of the Eukaryotic RibosomeQ27658581
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The initiation of mammalian protein synthesis and mRNA scanning mechanismQ27679159
The crystal structure of the eukaryotic 40S ribosomal subunit in complex with eIF1 and eIF1AQ27685218
A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codonQ27932344
The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosomeQ27934357
Development and characterization of a reconstituted yeast translation initiation system.Q27934924
Uncharged tRNA activates GCN2 by displacing the protein kinase moiety from a bipartite tRNA-binding domainQ27936337
Yeast eIF4B binds to the head of the 40S ribosomal subunit and promotes mRNA recruitment through its N-terminal and internal repeat domainsQ27936401
New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sitesQ28131597
5-Fluoroorotic acid as a selective agent in yeast molecular geneticsQ28131614
Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNA(i)(Met) binding to the ribosomeQ33573600
The eIF1A C-terminal domain promotes initiation complex assembly, scanning and AUG selection in vivoQ34116876
The mechanism of eukaryotic translation initiation: new insights and challengesQ34289214
Structural changes enable start codon recognition by the eukaryotic translation initiation complexQ34440678
Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivoQ34628703
Molecular mechanism of scanning and start codon selection in eukaryotesQ35192105
Initiation factor eIF2γ promotes eIF2-GTP-Met-tRNAi(Met) ternary complex binding to the 40S ribosomeQ35534370
N- and C-terminal residues of eIF1A have opposing effects on the fidelity of start codon selectionQ35691356
Coordinated movements of eukaryotic translation initiation factors eIF1, eIF1A, and eIF5 trigger phosphate release from eIF2 in response to start codon recognition by the ribosomal preinitiation complexQ36636060
Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selectionQ36843520
Kinetic analysis of late steps of eukaryotic translation initiationQ37124823
Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing.Q37318477
Conserved residues in yeast initiator tRNA calibrate initiation accuracy by regulating preinitiation complex stability at the start codonQ37631233
The scanning mechanism of eukaryotic translation initiationQ38185457
Kinetic and thermodynamic analysis of the role of start codon/anticodon base pairing during eukaryotic translation initiationQ42003947
Yeast initiator tRNA identity elements cooperate to influence multiple steps of translation initiationQ43076728
Pi release from eIF2, not GTP hydrolysis, is the step controlled by start-site selection during eukaryotic translation initiationQ46772123
Reconstitution of yeast translation initiation.Q46968946
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)2293-2312
P577publication date2015-02-10
P1433published inNucleic Acids ResearchQ135122
P1476titleConformational changes in the P site and mRNA entry channel evoked by AUG recognition in yeast translation preinitiation complexes
P478volume43