The mechanisms of calcium cycling and action potential dynamics in cardiac alternans

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The mechanisms of calcium cycling and action potential dynamics in cardiac alternans is …
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scholarly articleQ13442814

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P356DOI10.1161/CIRCRESAHA.116.305404
P932PMC publication ID4344847
P698PubMed publication ID25532796

P50authorGiedrius KanaporisQ84746786
P2093author name stringLothar A Blatter
P2860cites workDifferential expression of small-conductance Ca2+-activated K+ channels SK1, SK2, and SK3 in mouse atrial and ventricular myocytesQ28507538
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Model of intracellular calcium cycling in ventricular myocytesQ34183912
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Repolarization alternans reveals vulnerability to human atrial fibrillationQ35103212
Role of substrate and triggers in the genesis of cardiac alternans, from the myocyte to the whole heart: implications for therapyQ35762284
Mechanisms by which cytoplasmic calcium wave propagation and alternans are generated in cardiac atrial myocytes lacking T-tubules-insights from a simulation studyQ35866809
Refractoriness of sarcoplasmic reticulum Ca2+ release determines Ca2+ alternans in atrial myocytesQ36042661
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Calcium alternans in a couplon network model of ventricular myocytes: role of sarcoplasmic reticulum loadQ36176145
A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart ratesQ36303175
Regulation of cardiac alternans by β-adrenergic signaling pathwaysQ36312540
From pulsus to pulseless: the saga of cardiac alternansQ36489923
Calcium alternans in cardiac myocytes: order from disorderQ36604970
Proarrhythmic effect of blocking the small conductance calcium activated potassium channel in isolated canine left atrium.Q36874619
Mechanisms of calcium transient and action potential alternans in cardiac cells and tissuesQ36977081
Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart: ryanodine receptor refractoriness during alternans and fibrillationQ37724865
T-wave alternans as a therapeutic marker for antiarrhythmic agentsQ37765792
Ultra-rapid delayed rectifier channels: molecular basis and therapeutic implicationsQ37821136
Alternans and arrhythmias: from cell to heartQ37826594
Atrial cardiomyocyte calcium signalling.Q37835985
Role of calcium cycling versus restitution in the mechanism of repolarization alternansQ39678571
Action potential duration alternans in dog Purkinje and ventricular muscle fibers. Further evidence in support of two different mechanismsQ41273169
Alternans of action potential duration after abrupt shortening of cycle length: differences between dog Purkinje and ventricular muscle fibersQ41435751
Sarcolipin and phospholamban mRNA and protein expression in cardiac and skeletal muscle of different species.Q41768288
Non-linear dynamics of cardiac alternans: subcellular to tissue-level mechanisms of arrhythmiaQ42064986
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T-tubule remodeling during transition from hypertrophy to heart failure.Q42488509
Subcellular Ca2+ alternans represents a novel mechanism for the generation of arrhythmogenic Ca2+ waves in cat atrial myocytesQ44218016
Increasing prevalence of atrial fibrillation and flutter in the United StatesQ44353676
Depletion of T-tubules and specific subcellular changes in sarcolemmal proteins in tachycardia-induced heart failure.Q44493079
Sarcoplasmic reticulum calcium content fluctuation is the key to cardiac alternansQ44748799
Action potential duration determines sarcoplasmic reticulum Ca2+ reloading in mammalian ventricular myocytesQ44970472
Atrium-specific Kir3.x determines inducibility, dynamics, and termination of fibrillation by regulating restitution-driven alternans.Q45065186
Action potential duration restitution and alternans in rabbit ventricular myocytes: the key role of intracellular calcium cycling.Q45232102
Calcium-activated chloride current contributes to action potential alternations in left ventricular hypertrophy rabbitQ45402555
The effects of membrane potential, SR Ca2+ content and RyR responsiveness on systolic Ca2+ alternans in rat ventricular myocytesQ46157374
Effect of ischemia on calcium-dependent fluorescence transients in rabbit hearts containing indo 1. Correlation with monophasic action potentials and contractionQ46210593
Molecular correlates of repolarization alternans in cardiac myocytesQ46606487
Discordant repolarization alternans-induced atrial fibrillation is suppressed by verapamilQ46772503
Remodeling of T-tubules and reduced synchrony of Ca2+ release in myocytes from chronically ischemic myocardiumQ46850862
Regional differences in spontaneous Ca2+ spark activity and regulation in cat atrial myocytesQ46949460
Calcium-activated transient membrane currents are carried mainly by chloride ions in isolated atrial, ventricular and Purkinje cells of rabbit heartQ48479533
Period-doubling bifurcation in an array of coupled stochastically excitable elements subjected to global periodic forcingQ50324142
Diagnosis of malignant pericarditis: a single centre experience.Q50894030
Are SR Ca content fluctuations or SR refractoriness the key to atrial cardiac alternans?: insights from a human atrial model.Q51103578
Mechanism of repolarization alternans has restitution of action potential duration dependent and independent components.Q51284789
Condition for alternans and its control in a two-dimensional mapping model of paced cardiac dynamics.Q51999348
Mathematical analysis of dynamics of cardiac memory and accommodation: theory and experiment.Q52013924
Expression of cardiac calcium regulatory proteins in atrium v ventricle in different species.Q52176417
Gene expression profiling of human cardiac potassium and sodium channels.Q54633508
Alternans of intracellular calcium: Mechanism and significanceQ60182021
Sarcoplasmic reticulum and L-type Ca²⁺ channel activity regulate the beat-to-beat stability of calcium handling in human atrial myocytesQ61479656
A graphic method for the study of alternation in cardiac action potentialsQ72080012
Analysis of mechanical alternans in rabbit papillary muscleQ72685731
Regional expression of phospholamban in the human heartQ73119983
Cellular and ionic basis for T-wave alternans under long-QT conditionsQ74624503
Ionic mechanism of electrical alternansQ77481025
Effect of action potential duration and conduction velocity restitution and their spatial dispersion on alternans and the stability of arrhythmiasQ78637534
Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuationsQ80199022
Altered dynamics of action potential restitution and alternans in humans with structural heart diseaseQ81203192
Microvolt T-wave alternans testing has a role in arrhythmia risk stratificationQ83932912
Atrial repolarization alternans as a path to atrial fibrillationQ84567144
The TRPM4 non-selective cation channel contributes to the mammalian atrial action potentialQ86139215
P433issue5
P304page(s)846-856
P577publication date2014-12-22
P1433published inCirculation ResearchQ2599020
P1476titleThe mechanisms of calcium cycling and action potential dynamics in cardiac alternans
P478volume116

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cites work (P2860)
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Q39360546Calcium Signaling and Cardiac Arrhythmias
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Q42353140Mesenchymal stem cells suppress cardiac alternans by activation of PI3K mediated nitroso-redox pathway
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Q46728303Stochastic pacing reveals the propensity to cardiac action potential alternans and uncovers its underlying dynamics
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Q89479718The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2+-ATPase, is a major determinant of Ca2+ alternans in intact mouse hearts
Q90698920Transient outward K+ current can strongly modulate action potential duration and initiate alternans in the human atrium
Q89178787Transverse cardiac slicing and optical imaging for analysis of transmural gradients in membrane potential and Ca2+ transients in murine heart

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