The effects of membrane potential, SR Ca2+ content and RyR responsiveness on systolic Ca2+ alternans in rat ventricular myocytes

scientific article published on 19 January 2009

The effects of membrane potential, SR Ca2+ content and RyR responsiveness on systolic Ca2+ alternans in rat ventricular myocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1113/JPHYSIOL.2008.164368
P932PMC publication ID2674997
P698PubMed publication ID19153161
P5875ResearchGate publication ID23800877

P50authorMary E DíazQ59544922
David A. EisnerQ29382788
P2093author name stringYatong Li
Stephen O'Neill
P2860cites workDepressed ryanodine receptor activity increases variability and duration of the systolic Ca2+ transient in rat ventricular myocytes.Q44167970
Sarcoplasmic reticulum calcium content fluctuation is the key to cardiac alternansQ44748799
Modulation of CICR has no maintained effect on systolic Ca2+: simultaneous measurements of sarcoplasmic reticulum and sarcolemmal Ca2+ fluxes in rat ventricular myocytes.Q52082843
Model of mechanical alternans in the mammalian myocardium.Q52204263
A mechanism distinct from the L-type Ca current or Na–Ca exchange contributes to Ca entry in rat ventricular myocytesQ60182020
Alternans of intracellular calcium: Mechanism and significanceQ60182021
A novel, rapid and reversible method to measure Ca buffering and time-course of total sarcoplasmic reticulum Ca content in cardiac ventricular myocytesQ60182050
A mechanism for the effects of caffeine on Ca2+ release during diastole and systole in isolated rat ventricular myocytesQ60182124
The effects of metabolic inhibition on intracellular calcium and pH in isolated rat ventricular cellsQ60182151
Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuationsQ80199022
Coordinated control of cell Ca(2+) loading and triggered release from the sarcoplasmic reticulum underlies the rapid inotropic response to increased L-type Ca(2+) currentQ31829229
Pacing-induced heterogeneities in intracellular Ca2+ signaling, cardiac alternans, and ventricular arrhythmias in intact rat heartQ33256786
Integrative analysis of calcium cycling in cardiac muscleQ34101069
Simulated calcium current can both cause calcium loading in and trigger calcium release from the sarcoplasmic reticulum of a skinned canine cardiac Purkinje cellQ36409341
From pulsus to pulseless: the saga of cardiac alternansQ36489923
Cellular and subcellular alternans in the canine left ventricleQ36631301
Calsequestrin-mediated mechanism for cellular calcium transient alternansQ36908304
The link between repolarisation alternans and ventricular arrhythmia: does the cellular phenomenon extend to the clinical problem?Q37172611
Regulation of current flow through ryanodine receptors by luminal Ca2+.Q41602511
Alternans of cardiac calcium cycling in a cluster of ryanodine receptors: a simulation study.Q42119646
Luminal Ca2+ controls termination and refractory behavior of Ca2+-induced Ca2+ release in cardiac myocytesQ44128029
P433issuePt 6
P407language of work or nameEnglishQ1860
P921main subjectsystoleQ496359
P304page(s)1283-1292
P577publication date2009-01-19
P1433published inJournal of PhysiologyQ7743612
P1476titleThe effects of membrane potential, SR Ca2+ content and RyR responsiveness on systolic Ca2+ alternans in rat ventricular myocytes
P478volume587

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cites work (P2860)
Q37352873A unified theory of calcium alternans in ventricular myocytes
Q38699661Alternans in atria: Mechanisms and clinical relevance
Q42000857An Excel-based implementation of the spectral method of action potential alternans analysis
Q37499221Ca(2+)-activated chloride channel activity during Ca(2+) alternans in ventricular myocytes.
Q34333604Ca2+ Overload and Sarcoplasmic Reticulum Instability in tric-a Null Skeletal Muscle
Q90248065Calcium Handling Defects and Cardiac Arrhythmia Syndromes
Q36176145Calcium alternans in a couplon network model of ventricular myocytes: role of sarcoplasmic reticulum load
Q36604970Calcium alternans in cardiac myocytes: order from disorder
Q53245916Calcium-activated chloride current determines action potential morphology during calcium alternans in atrial myocytes.
Q34004209Cardiac alternans and intracellular calcium cycling
Q36042668Cardiac arrhythmia mechanisms in rats with heart failure induced by pulmonary hypertension.
Q37640381Cellular mechanism of cardiac alternans: an unresolved chicken or egg problem
Q36943418Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarizations, and fibrillation
Q60182008Do calcium waves propagate between cells and synchronize alternating calcium release in rat ventricular myocytes?
Q42367438Increased Ca buffering underpins remodelling of Ca2+ handling in old sheep atrial myocytes
Q60181996Increased Vulnerability to Atrial Fibrillation Is Associated With Increased Susceptibility to Alternans in Old Sheep
Q27009543Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence
Q34245774Nonlinear and Stochastic Dynamics in the Heart
Q36042661Refractoriness of sarcoplasmic reticulum Ca2+ release determines Ca2+ alternans in atrial myocytes
Q36312540Regulation of cardiac alternans by β-adrenergic signaling pathways
Q61479656Sarcoplasmic reticulum and L-type Ca²⁺ channel activity regulate the beat-to-beat stability of calcium handling in human atrial myocytes
Q33946288Spark-induced sparks as a mechanism of intracellular calcium alternans in cardiac myocytes
Q37408468Spatiotemporal intracellular calcium dynamics during cardiac alternans
Q35069142T-tubule disruption promotes calcium alternans in failing ventricular myocytes: mechanistic insights from computational modeling
Q37834308T-wave alternans and arrhythmogenesis in cardiac diseases
Q35132301The mechanisms of calcium cycling and action potential dynamics in cardiac alternans
Q34691870The role of mitochondria for the regulation of cardiac alternans

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