Global repression of host-associated genes of the Lyme disease spirochete through post-transcriptional modulation of the alternative sigma factor RpoS

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Global repression of host-associated genes of the Lyme disease spirochete through post-transcriptional modulation of the alternative sigma factor RpoS is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...993141D
P356DOI10.1371/JOURNAL.PONE.0093141
P932PMC publication ID3966842
P698PubMed publication ID24671196
P5875ResearchGate publication ID261138010

P2093author name stringPatricia A Rosa
Daniel P Dulebohn
Beth M Hayes
P2860cites workGenomic sequence of a Lyme disease spirochaete, Borrelia burgdorferiQ22122357
Lyme disease-a tick-borne spirochetosis?Q22242252
Borrelia burgdorferi OspC protein required exclusively in a crucial early stage of mammalian infectionQ24548272
Temporal changes in outer surface proteins A and C of the lyme disease-associated spirochete, Borrelia burgdorferi, during the chain of infection in ticks and miceQ24550778
Induction of an outer surface protein on Borrelia burgdorferi during tick feedingQ24564198
Outer-surface protein C of the Lyme disease spirochete: a protein induced in ticks for infection of mammalsQ24624698
DsrA RNA regulates translation of RpoS message by an anti-antisense mechanism, independent of its action as an antisilencer of transcriptionQ24645477
Ticks and biting insects infected with the etiologic agent of Lyme disease, Borrelia burgdorferiQ24645861
A trans-acting RNA as a control switch in Escherichia coli: DsrA modulates function by forming alternative structuresQ24652762
Temporal expression analysis of the Borrelia burgdorferi paralogous gene family 54 genes BBA64, BBA65, and BBA66 during persistent infection in miceQ24684956
Borrelia burgdorferi requires the alternative sigma factor RpoS for dissemination within the vector during tick-to-mammal transmissionQ27347529
Regulation and expression of bba66 encoding an immunogenic infection-associated lipoprotein in Borrelia burgdorferi.Q54593451
Lyme DiseaseQ57485891
The Spirochetal Etiology of Lyme DiseaseQ58402764
Human Phagocytic Cells in the Early Innate Immune Response toBorrelia burgdorferiQ58424640
Site-specific DNA binding and bending by the Borrelia burgdorferi Hbb proteinQ74130007
Immune evasion by tickborne and host-adapted Borrelia burgdorferiQ74184800
Modification of Borrelia burgdorferi to overproduce OspA or VlsE alters its infectious behaviourQ79716377
Temperature-induced regulation of RpoS by a small RNA in Borrelia burgdorferiQ80335083
Role of acetyl-phosphate in activation of the Rrp2-RpoN-RpoS pathway in Borrelia burgdorferiQ28475520
Increasing the interaction of Borrelia burgdorferi with decorin significantly reduces the 50 percent infectious dose and severely impairs disseminationQ30479936
Assessment of decorin-binding protein A to the infectivity of Borrelia burgdorferi in the murine models of needle and tick infectionQ33338260
Altered stationary-phase response in a Borrelia burgdorferi rpoS mutantQ33603276
Rrp1, a cyclic-di-GMP-producing response regulator, is an important regulator of Borrelia burgdorferi core cellular functionsQ33745332
Efficient targeted mutagenesis in Borrelia burgdorferiQ33789903
Effects of environmental pH on membrane proteins in Borrelia burgdorferi.Q33876130
Analysis of the ospC regulatory element controlled by the RpoN-RpoS regulatory pathway in Borrelia burgdorferiQ33885745
Borrelia burgdorferi sigma54 is required for mammalian infection and vector transmission but not for tick colonizationQ33935887
Expression of Borrelia burgdorferi OspC and DbpA is controlled by a RpoN-RpoS regulatory pathwayQ33948046
Borrelia burgdorferi requires glycerol for maximum fitness during the tick phase of the enzootic cycleQ33959174
HrpA, a DEAH-box RNA helicase, is involved in global gene regulation in the Lyme disease spirocheteQ33981476
DNA microarray analysis of differential gene expression in Borrelia burgdorferi, the Lyme disease spirocheteQ34010197
Clonal polymorphism of Borrelia burgdorferi strain B31 MI: implications for mutagenesis in an infectious strain backgroundQ34120882
Alternate sigma factor RpoS is required for the in vivo-specific repression of Borrelia burgdorferi plasmid lp54-borne ospA and lp6.6 genesQ34124377
Biology of Borrelia speciesQ34182983
The RpoS-mediated general stress response in Escherichia coliQ34189650
Genome stability of Lyme disease spirochetes: comparative genomics of Borrelia burgdorferi plasmids.Q34202850
Identification and function of the RNA chaperone Hfq in the Lyme disease spirochete Borrelia burgdorferi.Q34238399
lacZ Reporter System for Use in Borrelia burgdorferiQ34290283
Bacteriophage T4 regA protein binds to mRNAs and prevents translation initiationQ34362535
Analysis of an ordered, comprehensive STM mutant library in infectious Borrelia burgdorferi: insights into the genes required for mouse infectivityQ34469139
CsrA Modulates Levels of Lipoproteins and Key Regulators of Gene Expression Critical for Pathogenic Mechanisms of Borrelia burgdorferiQ34529598
Outer surface lipoproteins of Borrelia burgdorferi stimulate nitric oxide production by the cytokine-inducible pathwayQ34535919
Antigenic and genetic heterogeneity of Borrelia burgdorferi populations transmitted by ticksQ34625361
Defining the plasmid-borne restriction-modification systems of the Lyme disease spirochete Borrelia burgdorferi.Q34740450
Profiling of temperature-induced changes in Borrelia burgdorferi gene expression by using whole genome arraysQ34855118
Increasing RpoS expression causes cell death in Borrelia burgdorferiQ35073052
A stress sensor for the bacterial periplasmQ35101072
Nitrosative damage to free and zinc-bound cysteine thiols underlies nitric oxide toxicity in wild-type Borrelia burgdorferiQ35137909
The hybrid histidine kinase Hk1 is part of a two-component system that is essential for survival of Borrelia burgdorferi in feeding Ixodes scapularis ticksQ35139218
Decorin-binding proteins A and B confer distinct mammalian cell type-specific attachment by Borrelia burgdorferi, the Lyme disease spirocheteQ35163595
Borrelia burgdorferi linear plasmid 38 is dispensable for completion of the mouse-tick infectious cycle.Q35191923
Temperature-related differential expression of antigens in the Lyme disease spirochete, Borrelia burgdorferiQ35452406
Regulation of the virulence determinant OspC by bbd18 on linear plasmid lp17 of Borrelia burgdorferiQ38631499
BosR (BB0647) governs virulence expression in Borrelia burgdorferi.Q39372859
Sequential recognition of two distinct sites in sigma(S) by the proteolytic targeting factor RssB and ClpX.Q39832015
The cryptic ospC gene of Borrelia burgdorferi B31 is located on a circular plasmid.Q40267204
Hfq (HF1) stimulates ompA mRNA decay by interfering with ribosome bindingQ40443123
Verification and dissection of the ospC operator by using flaB promoter as a reporter in Borrelia burgdorferiQ41189015
Proteases and their targets in Escherichia coliQ41291324
Both decorin-binding proteins A and B are critical for the overall virulence of Borrelia burgdorferiQ41960261
Analysis of the RpoS regulon in Borrelia burgdorferi in response to mammalian host signals provides insight into RpoS function during the enzootic cycleQ42392366
Inactivation of bb0184, which encodes carbon storage regulator A, represses the infectivity of Borrelia burgdorferi.Q42706647
The cellular level of the recognition factor RssB is rate-limiting for sigmaS proteolysis: implications for RssB regulation and signal transduction in sigmaS turnover in Escherichia coli.Q44158542
Growth kinetics of the Lyme disease spirochete (Borrelia burgdorferi) in vector ticks (Ixodes dammini).Q44237385
Identification of an ospC operator critical for immune evasion of Borrelia burgdorferiQ44893885
A conservative amino acid change alters the function of BosR, the redox regulator of Borrelia burgdorferiQ45156915
Impaired host defense to infection and Toll-like receptor 2-independent killing of Borrelia burgdorferi clinical isolates in TLR2-deficient C3H/HeJ miceQ48029801
Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi.Q54517987
CsrA regulates glycogen biosynthesis by preventing translation of glgC in Escherichia coli.Q54543711
OspA antibodies inhibit the acquisition of Borrelia burgdorferi by Ixodes ticksQ35552349
Sigma factors and global gene regulation in Mycobacterium tuberculosisQ35648489
Rapid clearance of Lyme disease spirochetes lacking OspC from skinQ35689460
Evidence that RpoS (sigmaS) in Borrelia burgdorferi is controlled directly by RpoN (sigma54/sigmaN).Q35759377
Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferiQ35873530
The response regulator Rrp2 is essential for the expression of major membrane lipoproteins in Borrelia burgdorferiQ35978799
Insights into the complex regulation of rpoS in Borrelia burgdorferiQ35990803
Effect of levels of acetate on the mevalonate pathway of Borrelia burgdorferiQ36000800
Borrelia oxidative stress response regulator, BosR: a distinctive Zn-dependent transcriptional activatorQ36161498
Competitive advantage of Borrelia burgdorferi with outer surface protein BBA03 during tick-mediated infection of the mammalian hostQ36277353
Essential role for OspA/B in the life cycle of the Lyme disease spirocheteQ36403858
Borrelia burgdorferi membranes are the primary targets of reactive oxygen speciesQ36575540
Translational efficiency of rpoS mRNA from Borrelia burgdorferi: effects of the length and sequence of the mRNA leader region.Q36739625
Borrelia host adaptation Regulator (BadR) regulates rpoS to modulate host adaptation and virulence factors in Borrelia burgdorferi.Q36789833
Outer surface protein A protects Lyme disease spirochetes from acquired host immunity in the tick vectorQ36949994
Essential protective role attributed to the surface lipoproteins of Borrelia burgdorferi against innate defencesQ36953212
Borrelia burgdorferi bba66 gene inactivation results in attenuated mouse infection by tick transmissionQ36970853
Borrelia burgdorferi lacking DbpBA exhibits an early survival defect during experimental infectionQ36974447
An inverted repeat in the ospC operator is required for induction in Borrelia burgdorferiQ36980995
A Borrelia-specific monoclonal antibody binds to a flagellar epitopeQ37029399
Role of RpoS in the virulence of Citrobacter rodentiumQ37033120
Borrelia burgdorferi bba74 is expressed exclusively during tick feeding and is regulated by both arthropod- and mammalian host-specific signalsQ37157095
Regulation by destruction: design of the sigmaE envelope stress responseQ37317326
A new animal model for studying Lyme disease spirochetes in a mammalian host-adapted stateQ37382131
Abrogation of ospAB constitutively activates the Rrp2-RpoN-RpoS pathway (sigmaN-sigmaS cascade) in Borrelia burgdorferi.Q37471990
Combined effects of blood and temperature shift on Borrelia burgdorferi gene expression as determined by whole genome DNA arrayQ37521727
RpoS is not central to the general stress response in Borrelia burgdorferi but does control expression of one or more essential virulence determinantsQ37582867
Proteolysis of sigmaS (RpoS) and the general stress response in Escherichia coliQ37600115
BBE02 disruption mutants of Borrelia burgdorferi B31 have a highly transformable, infectious phenotypeQ37623542
Role of RpoS in virulence of pathogens.Q37641571
Lyme borreliosis: relation of its causative agent to its vectors and hosts in North America and EuropeQ37672965
Regulation of alternative sigma factor use.Q37884597
Gene regulation in Borrelia burgdorferiQ37908132
Constitutive expression of outer surface protein C diminishes the ability of Borrelia burgdorferi to evade specific humoral immunityQ38481937
P275copyright licenseCreative Commons CC0 LicenseQ6938433
P6216copyright statuscopyrighted, dedicated to the public domain by copyright holderQ88088423
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectLyme diseaseQ201989
P304page(s)e93141
P577publication date2014-03-26
P1433published inPLOS OneQ564954
P1476titleGlobal repression of host-associated genes of the Lyme disease spirochete through post-transcriptional modulation of the alternative sigma factor RpoS
P478volume9

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cites work (P2860)
Q35760195Absence of sodA Increases the Levels of Oxidation of Key Metabolic Determinants of Borrelia burgdorferi
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Q91700570DNA Methylation by Restriction Modification Systems Affects the Global Transcriptome Profile in Borrelia burgdorferi
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