| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Karin Fransén | Q101403077 |
| Geena Paramel Varghese | Q58427448 | ||
| P2093 | author name string | A Sirsjö | |
| K Fransén | |||
| P2860 | cites work | Lack of Interleukin-1β Decreases the Severity of Atherosclerosis in ApoE-Deficient Mice | Q62735862 |
| Genetics of ankylosing spondylitis | Q78605064 | ||
| The missense variation Q705K in CIAS1/NALP3/NLRP3 gene and an NLRP1 haplotype are associated with celiac disease | Q83232727 | ||
| Genetic association between NLRP3 variants and Crohn's disease does not replicate in a large UK panel | Q84075140 | ||
| Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome | Q84155882 | ||
| Cutting edge: nitric oxide inhibits the NLRP3 inflammasome | Q85277117 | ||
| Alzheimer's Disease | Q22248111 | ||
| Inflammatory Bowel Disease | Q22248115 | ||
| CARDINAL, a novel caspase recruitment domain protein, is an inhibitor of multiple NF-kappa B activation pathways | Q24291679 | ||
| Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome | Q24291856 | ||
| IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines | Q24294720 | ||
| Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction | Q24303900 | ||
| NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder | Q24317771 | ||
| Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls | Q24550675 | ||
| NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice | Q24604235 | ||
| New mutations of CIAS1 that are responsible for Muckle-Wells syndrome and familial cold urticaria: a novel mutation underlies both syndromes | Q24613164 | ||
| Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization | Q24631966 | ||
| The Nalp3 inflammasome is essential for the development of silicosis | Q24645580 | ||
| An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology | Q27004333 | ||
| A role for mitochondria in NLRP3 inflammasome activation | Q28131794 | ||
| Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data | Q28242645 | ||
| Tripartite-motif protein 30 negatively regulates NLRP3 inflammasome activation by modulating reactive oxygen species production | Q28593128 | ||
| A genome-wide in vitro bacterial-infection screen reveals human variation in the host response associated with inflammatory disease | Q28751982 | ||
| Common SNPs explain a large proportion of the heritability for human height | Q29547221 | ||
| Thioredoxin-interacting protein links oxidative stress to inflammasome activation | Q29614471 | ||
| The NALP3 inflammasome is involved in the innate immune response to amyloid-beta | Q29615595 | ||
| Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration | Q29615596 | ||
| NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals | Q29615704 | ||
| NLRP3 inflammasome activation: The convergence of multiple signalling pathways on ROS production? | Q29619524 | ||
| Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis | Q29619852 | ||
| Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations. Monitoring trends and determinants in cardiovascular disease. | Q50647592 | ||
| Polymorphisms in the NLRP3 gene and risk of primary gouty arthritis. | Q51066997 | ||
| The NLRP3 inflammasome is up-regulated in cardiac fibroblasts and mediates myocardial ischaemia-reperfusion injury. | Q51072106 | ||
| Combined polymorphisms in genes encoding the inflammasome components NALP3 and CARD8 confer susceptibility to Crohn's disease in Swedish men. | Q51752126 | ||
| T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. | Q51956133 | ||
| Two SNPs in NLRP3 gene are involved in the predisposition to type-1 diabetes and celiac disease in a pediatric population from northeast Brazil. | Q54433700 | ||
| Interaction of the inflammasome genes CARD8 and NLRP3 in abdominal aortic aneurysms | Q57154848 | ||
| Evidence of interaction of CARD8 rs2043211 with NALP3 rs35829419 in Crohn's disease | Q57154899 | ||
| Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation | Q57258441 | ||
| Genetic variants inCARD8but not inNLRP3are associated with ankylosing spondylitis | Q57623459 | ||
| Genetic variation in proteins of the cryopyrin inflammasome influences susceptibility and severity of rheumatoid arthritis (The Swedish TIRA project) | Q59727743 | ||
| CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis | Q30668600 | ||
| The Q705K polymorphism in NLRP3 is a gain-of-function alteration leading to excessive interleukin-1β and IL-18 production | Q31057510 | ||
| Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation | Q33644572 | ||
| CARD8 is a negative regulator for NLRP3 inflammasome, but mutant NLRP3 in cryopyrin-associated periodic syndromes escapes the restriction. | Q33765679 | ||
| Prediction and pathogenesis in type 1 diabetes. | Q33818896 | ||
| TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer. | Q33951635 | ||
| HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease | Q33998193 | ||
| The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. | Q34246151 | ||
| The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis | Q34313840 | ||
| The inflammatory response in myocardial infarction | Q34463456 | ||
| TUCAN (CARD8) genetic variants and inflammatory bowel disease. | Q34572565 | ||
| Myocardial reperfusion injury. | Q34687124 | ||
| Blocking interleukin-1 in rheumatic diseases | Q34822708 | ||
| Celiac disease: from pathogenesis to novel therapies | Q35004094 | ||
| Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome | Q35006409 | ||
| Cytokine profile in a cohort of healthy blood donors carrying polymorphisms in genes encoding the NLRP3 inflammasome | Q35009123 | ||
| Measles virus V protein inhibits NLRP3 inflammasome-mediated interleukin-1β secretion | Q35599347 | ||
| Clinical relevance of single nucleotide polymorphisms within the entire NLRP3 gene in patients with major blunt trauma | Q36073123 | ||
| Critical role for calcium mobilization in activation of the NLRP3 inflammasome | Q36094313 | ||
| Blocking IL-1 in systemic inflammation | Q36113777 | ||
| Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities | Q36321572 | ||
| High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome: results of an International Multicenter Collaborative Study | Q36399888 | ||
| CARD8 rs2043211 (p.C10X) polymorphism is not associated with disease susceptibility or cardiovascular events in Spanish rheumatoid arthritis patients | Q36490766 | ||
| Interleukin-18 in chronic joint diseases | Q36743382 | ||
| Effects of interleukin-1 blockade with anakinra on adverse cardiac remodeling and heart failure after acute myocardial infarction [from the Virginia Commonwealth University-Anakinra Remodeling Trial (2) (VCU-ART2) pilot study]. | Q36816882 | ||
| Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β. | Q37040409 | ||
| Interleukin-1 antagonism in type 1 diabetes of recent onset: two multicentre, randomised, double-blind, placebo-controlled trials | Q37307777 | ||
| Common variants in the NLRP3 region contribute to Crohn's disease susceptibility | Q37310504 | ||
| Interleukin 1 induces leukocyte infiltration and cartilage proteoglycan degradation in the synovial joint | Q37408069 | ||
| Q705K variant in NLRP3 gene confers protection against myocardial infarction in female individuals | Q37565584 | ||
| Regulation of CARD8 expression by ANRIL and association of CARD8 single nucleotide polymorphism rs2043211 (p.C10X) with ischemic stroke | Q37656227 | ||
| Heterogeneity of CNS myeloid cells and their roles in neurodegeneration | Q37939514 | ||
| Association of NLRP3 and CARD8 genetic polymorphisms with juvenile idiopathic arthritis in a Taiwanese population. | Q38167854 | ||
| Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth | Q39234393 | ||
| NLRP3 inflammasome activity is negatively controlled by miR-223. | Q39277506 | ||
| Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production | Q39277512 | ||
| Role of NLRP3 and CARD8 in the regulation of TNF-α induced IL-1β release in vascular smooth muscle cells | Q39600382 | ||
| Caspase recruitment domain-containing protein 8 (CARD8) negatively regulates NOD2-mediated signaling | Q39715701 | ||
| Expression and function of the NALP3 inflammasome in rheumatoid synovium. | Q39788053 | ||
| Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation. | Q40021792 | ||
| Gene polymorphisms in the NALP3 inflammasome are associated with interleukin-1 production and severe inflammation: relation to common inflammatory diseases? | Q40425740 | ||
| Association between celiac sprue and cryopyrin associated autoinflammatory disorders: a case report. | Q40448119 | ||
| Cytokines regulate vascular functions related to stability of the atherosclerotic plaque | Q41028054 | ||
| Morphology of left anterior descending coronary territory lesions as a predictor of anterior myocardial infarction: a CASS Registry Study | Q41232383 | ||
| Initial description of the human NLRP3 promoter | Q42410812 | ||
| Associations of functional NLRP3 polymorphisms with susceptibility to food-induced anaphylaxis and aspirin-induced asthma | Q43274045 | ||
| No association of the CARD8 (TUCAN) c.30T>A (p.C10X) variant with Crohn's disease: a study in 3 independent European cohorts | Q43433871 | ||
| CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation. | Q43781538 | ||
| Association of CARD8 with inflammatory bowel disease in Koreans | Q43850995 | ||
| The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis | Q44499855 | ||
| Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study). | Q44956453 | ||
| NLRP3 polymorphisms are associated with late-onset Alzheimer's disease in Han Chinese | Q45271670 | ||
| HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus | Q46138865 | ||
| CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis | Q47797398 | ||
| A poxvirus-encoded pyrin domain protein interacts with ASC-1 to inhibit host inflammatory and apoptotic responses to infection | Q48108353 | ||
| Deficiency of CARD8 is associated with increased Alzheimer's disease risk in women | Q48890548 | ||
| Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production | Q50335883 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P921 | main subject | peptide | Q172847 |
| transport protein | Q2111029 | ||
| neoplasm protein | Q66894191 | ||
| CARD signaling adaptor proteins | Q77040095 | ||
| P304 | page(s) | 846782 | |
| P577 | publication date | 2015-02-18 | |
| P1433 | published in | Mediators of Inflammation | Q2144494 |
| P1476 | title | Role of genetic alterations in the NLRP3 and CARD8 genes in health and disease | |
| P478 | volume | 2015 |
| Q64929997 | Association between caspase recruitment domain-containing protein 8 rs2043211 polymorphism and cardiovascular disease susceptibility: A systematic review and meta-analysis. |
| Q55233786 | Association of NLRP1 and NLRP3 Polymorphisms with Psoriasis Vulgaris Risk in the Chinese Han Population. |
| Q47795988 | Association of NLRP3 polymorphisms with susceptibility to primary gouty arthritis in a Chinese Han population |
| Q47661727 | COPs and POPs Patrol Inflammasome Activation |
| Q64102636 | Dual Role of PTPN22 but Not NLRP3 Inflammasome Polymorphisms in Type 1 Diabetes and Celiac Disease in Children |
| Q101403078 | Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells |
| Q91805448 | Fungal cutaneous microbiome and host determinants in preterm and term neonates |
| Q51025124 | Inhibition of NLRP3 Inflammasome Prevents LPS-Induced Inflammatory Hyperalgesia in Mice: Contribution of NF-κB, Caspase-1/11, ASC, NOX, and NOS Isoforms. |
| Q92309417 | Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury |
| Q88074638 | Lower activation of caspase-1 by Staphylococcus epidermidis isolated from prosthetic joint infections compared to commensals |
| Q36159273 | Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout |
| Q38680628 | NLR-regulated pathways in cancer: opportunities and obstacles for therapeutic interventions |
| Q43372985 | NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats. |
| Q46142019 | NLRP3 inflammasome driven liver injury and fibrosis: Roles of IL- 17 and TNF. |
| Q52728109 | Nlrp3-dependent IL-1β inhibits CD103+ dendritic cell differentiation in the gut. |
| Q40071267 | Periodic Fever with Aphthous Stomatitis, Pharyngitis, and Cervical Adenitis Syndrome Is Associated with a CARD8 Variant Unable To Bind the NLRP3 Inflammasome. |
| Q92755416 | Phytochemicals as Novel Therapeutic Strategies for NLRP3 Inflammasome-Related Neurological, Metabolic, and Inflammatory Diseases |
| Q92094375 | Polymorphism of nucleotide binding domain-like receptor protein 3 (NLRP3) increases susceptibility of total urinary arsenic to renal cell carcinoma |
| Q49915054 | Polymorphisms and expression of inflammasome genes are associated with the development and severity of rheumatoid arthritis in Brazilian patients |
| Q89810152 | Relationship of CARD8 Gene Polymorphisms with Susceptibility to Ankylosing Spondylitis: A Case-Control Study |
| Q26769682 | Small Heterodimer Partner and Innate Immune Regulation |
Search more.