Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes

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Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1100539
P8608Fatcat IDrelease_uvmz7n66mzbh3cehbrkwcveuoq
P932PMC publication ID3150302
P698PubMed publication ID21775681
P5875ResearchGate publication ID51508241

P50authorJohn M. LachinQ37391755
Kevan C HeroldQ87494800
P2093author name stringZhugong Liu
Lisa M Spain
Mark D Pescovitz
Kasia Bourcier
Paula McGee
Heidi Krause-Steinrauf
Adam Asare
Type 1 Diabetes TrialNet Anti-CD20 Study Group
H Michael Dosch
P2860cites workGenetics, pathogenesis and clinical interventions in type 1 diabetesQ28281029
T cell activation and anergy to islet cell antigen in type I diabetesQ28305536
Changes in B- and T-lymphocyte and chemokine levels with rituximab treatment in multiple sclerosis.Q34052870
A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responsesQ34778834
The role of B lymphocytes as key antigen-presenting cells in the development of T cell-mediated autoimmune type 1 diabetesQ34984434
B cells in autoimmune diabetesQ35612697
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in healthQ35632007
B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null miceQ36367653
Mixed-meal tolerance test versus glucagon stimulation test for the assessment of beta-cell function in therapeutic trials in type 1 diabetesQ36906207
B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic miceQ37220772
Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes.Q37400735
Autoimmune islet destruction in spontaneous type 1 diabetes is not beta-cell exclusive.Q38358439
IFN-alpha and IL-10 induce the differentiation of human type 1 T regulatory cells.Q40811244
ICA69(null) nonobese diabetic mice develop diabetes, but resist disease acceleration by cyclophosphamide.Q43829949
ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease?Q48563733
Type I diabetes and multiple sclerosis patients target islet plus central nervous system autoantigens; nonimmunized nonobese diabetic mice can develop autoimmune encephalitis.Q49071770
Abnormal T-cell reactivities in childhood inflammatory demyelinating disease and type 1 diabetes.Q53522198
Persistent T cell anergy in human type 1 diabetes.Q54070212
Analysis of T-Cell Assays to Measure Autoimmune Responses in Subjects With Type 1 DiabetesQ57158832
Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell FunctionQ57491711
Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic miceQ68123525
Following a diabetogenic T cell from genesis through pathogenesisQ70488192
T helper cell subsets in insulin-dependent diabetesQ72265872
IL-10 and TGF-beta induce alloreactive CD4+CD25- T cells to acquire regulatory cell functionQ73062421
B-cells are required for the initiation of insulitis and sialitis in nonobese diabetic miceQ73373664
CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetesQ79843146
Investigation of the role of B-cells in type 1 diabetes in the NOD mouseQ80787816
Treatment with CD20-specific antibody prevents and reverses autoimmune diabetes in miceQ95789881
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttype-1 diabetesQ124407
rituximabQ412323
monoclonal antibodyQ422248
P304page(s)1998-2005
P577publication date2011-07-20
P1433published inJournal of ImmunologyQ3521441
P1476titleIncreased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetes
P478volume187

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cites work (P2860)
Q97682159A quantitative measure of treatment response in recent-onset type 1 diabetes
Q34380329Altered B cell homeostasis and toll-like receptor 9-driven response in type 1 diabetes carriers of the C1858T PTPN22 allelic variant: implications in the disease pathogenesis
Q38021696Autoimmunity in 2011.
Q52623971B cell depletion reduces T cell activation in pancreatic islets in a murine autoimmune diabetes model.
Q38220863Biomarkers in type 1 diabetes: application to the clinical trial setting
Q64120222Cell type-specific immune phenotypes predict loss of insulin secretion in new-onset type 1 diabetes
Q38071420Cell-based interventions to halt autoimmunity in type 1 diabetes mellitus.
Q33413423Diabetes and immune thrombocytopenic purpura: a new association with good response to anti-CD20 therapy
Q37243204Effect of abatacept on immunogenicity of vaccines in individuals with type 1 diabetes
Q89170907Elevated T cell levels in peripheral blood predict poor clinical response following rituximab treatment in new-onset type 1 diabetes
Q47907621Have we pushed the needle for treatment of Type 1 diabetes?
Q38016902Immunologic and metabolic biomarkers of β-cell destruction in the diagnosis of type 1 diabetes
Q48000827Intestinal type 1 regulatory T cells migrate to periphery to suppress diabetogenic T cells and prevent diabetes development.
Q37490637Involvement of suppressive B-lymphocytes in the mechanism of tolerogenic dendritic cell reversal of type 1 diabetes in NOD mice
Q37544980Large-scale prospective T cell function assays in shipped, unfrozen blood samples: experiences from the multicenter TRIGR trial
Q38385236Less is more: the detrimental consequences of immunosuppressive therapy in the treatment of type-1 diabetes
Q36995568Life and death of β cells in Type 1 diabetes: A comprehensive review
Q36141999Molecular imaging of atherosclerosis for improving diagnostic and therapeutic development
Q36650474New and future immunomodulatory therapy in type 1 diabetes
Q36807999Reactivation of latent viruses in individuals receiving rituximab for new onset type 1 diabetes
Q34077400Recommendations for the definition of clinical responder in insulin preservation studies
Q38013105Red carpeting the newer antidiabetics
Q34227866Reduction in CD4 central memory T-cell subset in costimulation modulator abatacept-treated patients with recent-onset type 1 diabetes is associated with slower C-peptide decline
Q38384138Reestablishing T Cell Tolerance by Antibody-Based Therapy in Type 1 Diabetes
Q44097749Restoring immune balance in type 1 diabetes
Q36430775Rituximab does not reset defective early B cell tolerance checkpoints
Q38679589Rituximab in Minimal Change Disease: Mechanisms of Action and Hypotheses for Future Studies
Q88697599Strength in Numbers: Opportunities for Enhancing the Development of Effective Treatments for Type 1 Diabetes-The TrialNet Experience
Q37006155Targeting regulatory T cells in the treatment of type 1 diabetes mellitus
Q37251153Teplizumab (anti-CD3 mAb) treatment preserves C-peptide responses in patients with new-onset type 1 diabetes in a randomized controlled trial: metabolic and immunologic features at baseline identify a subgroup of responders
Q35180980The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD mice
Q47577827The elusive role of B lymphocytes and islet autoantibodies in (human) type 1 diabetes
Q35787117The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes
Q38028889The long-term marriage between autoimmunity and internal medicine: a homage to Manuel Carlos Dias
Q88112314Type 1 Diabetes TrialNet: A Multifaceted Approach to Bringing Disease-Modifying Therapy to Clinical Use in Type 1 Diabetes
Q38117282Type 1 diabetes therapy beyond T cell targeting: monocytes, B cells, and innate lymphocytes
Q28287737Type 1 diabetes: translating mechanistic observations into effective clinical outcomes

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