The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes

scientific article published on 21 September 2015

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JAUT.2015.08.019
P932PMC publication ID4765310
P698PubMed publication ID26403950
P5875ResearchGate publication ID282277606

P50authorLi WenQ88313570
James A PearsonQ57339799
F. Susan WongQ63411298
P2093author name stringLi Wen
F Susan Wong
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HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetesQ82625833
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Low incidence of spontaneous type 1 diabetes in non-obese diabetic mice raised on gluten-free diets is associated with changes in the intestinal microbiomeQ21132451
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Chromogranin A is an autoantigen in type 1 diabetesQ24605199
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Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes.Q24679680
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NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cellsQ28207942
Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase CQ28270392
Breeding of a non-obese, diabetic strain of miceQ28276534
Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infectionQ28587620
A microbial symbiosis factor prevents intestinal inflammatory diseaseQ29614263
Identification of Novel Type 1 Diabetes Candidate Genes by Integrating Genome-Wide Association Data, Protein-Protein Interactions, and Human Pancreatic Islet Gene ExpressionQ30002303
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Identification of an MHC class I-restricted autoantigen in type 1 diabetes by screening an organ-specific cDNA library.Q30763625
Natural peptides selected by diabetogenic DQ8 and murine I-A(g7) molecules show common sequence specificityQ33220897
Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infectionQ33397372
Increasing incidence of pediatric type 1 diabetes mellitus in Southeastern Wisconsin: relationship with body weight at diagnosisQ33499699
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Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.Q33716675
Pre-existing autoimmunity determines type 1 diabetes outcome after Flt3-ligand treatmentQ33811836
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IRAK-M deficiency promotes the development of type 1 diabetes in NOD miceQ33959795
Compensatory mechanisms allow undersized anchor-deficient class I MHC ligands to mediate pathogenic autoreactive T cell responsesQ34053837
NLRP3 deficiency protects from type 1 diabetes through the regulation of chemotaxis into the pancreatic islets.Q36056835
Autoantigen-specific B-cell depletion overcomes failed immune tolerance in type 1 diabetesQ36109213
Mouse CD11b+Gr-1+ myeloid cells can promote Th17 cell differentiation and experimental autoimmune encephalomyelitisQ36339119
Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodiesQ36339650
Gr-1+CD11b+ myeloid cells tip the balance of immune protection to tumor promotion in the premetastatic lungQ36362003
CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells.Q36366075
B lymphocytes are essential for the initiation of T cell-mediated autoimmune diabetes: analysis of a new "speed congenic" stock of NOD.Ig mu null miceQ36367653
In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetesQ36375838
The role of lymphocyte subsets in accelerated diabetes in nonobese diabetic-rat insulin promoter-B7-1 (NOD-RIP-B7-1) miceQ36401103
Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor alpha chain gene rearrangementQ36526326
Hematopoietic stem-cell defects underlying abnormal macrophage development and maturation in NOD/Lt mice: defective regulation of cytokine receptors and protein kinase C.Q36603252
Beta-lactam antibiotics modulate T-cell functions and gene expression via covalent binding to cellular albuminQ36637602
Are insights gained from NOD mice sufficient to guide clinical translation? Another inconvenient truthQ36766166
B lymphocyte "original sin" in the bone marrow enhances islet autoreactivity in type 1 diabetes-prone nonobese diabetic miceQ36920508
Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in childrenQ36932173
Intracellular NOD-like receptors in innate immunity, infection and diseaseQ36974983
Combination treatment with anti-CD20 and oral anti-CD3 prevents and reverses autoimmune diabetes.Q37031014
TLR9 deficiency promotes CD73 expression in T cells and diabetes protection in nonobese diabetic mice.Q37210998
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-AQ37245361
A review of the current use of rituximab in autoimmune diseasesQ37322846
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NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2.Q40345753
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Oral probiotic administration induces interleukin-10 production and prevents spontaneous autoimmune diabetes in the non-obese diabetic mouseQ40409987
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Nonobese diabetic (NOD) mouse dendritic cells stimulate insulin secretion by prediabetic isletsQ40657321
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Immune therapy for type 1 diabetes mellitus-what is unique about anti-CD3 antibodies?Q34099969
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Diabetes and genderQ34155817
Genetic liability of type 1 diabetes and the onset age among 22,650 young Finnish twin pairs: a nationwide follow-up studyQ34186708
ZnT8-reactive T cells are weakly pathogenic in NOD mice but can participate in diabetes under inflammatory conditionsQ34227916
Reduced diabetes in btk-deficient nonobese diabetic mice and restoration of diabetes with provision of an anti-insulin IgH chain transgeneQ34267426
Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain.Q34307135
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TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cellsQ34468344
Islet-specific CTL cloned from a type 1 diabetes patient cause beta-cell destruction after engraftment into HLA-A2 transgenic NOD/scid/IL2RG null miceQ34479316
Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus.Q34566135
The first external domain of the nonobese diabetic mouse class II I-A beta chain is uniqueQ34614636
Anti-CD3 therapy promotes tolerance by selectively depleting pathogenic cells while preserving regulatory T cellsQ34630923
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A new Hu-PBL model for the study of human islet alloreactivity based on NOD-scid mice bearing a targeted mutation in the IL-2 receptor gamma chain gene.Q34728143
Anti-CD3 antibody induces long-term remission of overt autoimmunity in nonobese diabetic miceQ34904815
Analysis of islet inflammation in human type 1 diabetes.Q34917032
Toll-like receptor 3 is critical for coxsackievirus B4-induced type 1 diabetes in female NOD mice.Q34982303
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Extreme genetic risk for type 1A diabetesQ35024527
Increased T cell proliferative responses to islet antigens identify clinical responders to anti-CD20 monoclonal antibody (rituximab) therapy in type 1 diabetesQ35147560
Long term effect of gut microbiota transfer on diabetes developmentQ35157830
The role of Gr1+ cells after anti-CD20 treatment in type 1 diabetes in nonobese diabetic miceQ35180970
The dual effects of B cell depletion on antigen-specific T cells in BDC2.5NOD miceQ35180980
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Reversal of autoimmune diabetes by restoration of antigen-specific tolerance using genetically modified Lactococcus lactis in miceQ35913697
Beyond HLA-A*0201: new HLA-transgenic nonobese diabetic mouse models of type 1 diabetes identify the insulin C-peptide as a rich source of CD8+ T cell epitopesQ35981325
The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic modelQ36017123
T cell receptor restriction of diabetogenic autoimmune NOD T cellsQ36049067
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A Molecular Basis for MHC Class II—Associated AutoimmunityQ68355418
Recurrence of insulitis in the NOD mouse after early prolonged anti-CD4 monoclonal antibody treatmentQ69171827
Insulin autoantibodies in non-obese diabetic (NOD) miceQ69492420
Dendritic cells and scavenger macrophages in pancreatic islets of prediabetic BB ratsQ69554766
Evidence for initial involvement of macrophage in development of insulitis in NOD miceQ69830443
Time course of the lymphopenia in BB rats. Relation to the onset of diabetesQ69974798
Diabetes in identical twins. A study of 200 pairsQ70659026
The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitusQ71420898
Genetics of the BB rat: association of autoimmune disorders (diabetes, insulitis, and thyroiditis) with lymphopenia and major histocompatibility complex class IIQ71813277
The BB diabetic rat. Profound T-cell lymphocytopeniaQ72094521
Adoptive transfer of diabetes into immunodeficient NOD-scid/scid mice. Relative contributions of CD4+ and CD8+ T-cells from diabetic versus prediabetic NOD.NON-Thy-1a donorsQ72208453
Immunohistochemical characterization of monocytes-macrophages and dendritic cells involved in the initiation of the insulitis and beta-cell destruction in NOD miceQ72387387
Natural history of humoral immunity to glutamic acid decarboxylase in non-obese diabetic (NOD) miceQ72495270
Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB ratQ72779777
Beta 2-microglobulin-deficient NOD mice do not develop insulitis or diabetesQ72787287
Major histocompatibility complex class I-deficient NOD-B2mnull mice are diabetes and insulitis resistantQ72787291
Insulin autoantibodies are associated with islet inflammation but not always related to diabetes progression in NOD congenic miceQ73048923
CD3 antibody-induced dominant self tolerance in overtly diabetic NOD miceQ73128688
Generation and maintenance of autoantigen-specific CD8(+) T cell clones isolated from NOD miceQ73169623
An islet-homing NOD CD8+ cytotoxic T cell clone recognizes GAD65 and causes insulitisQ73174046
Substitution of aspartic acid at beta57 with alanine alters MHC class II peptide binding activity but not protein stability: HLA-DQ (alpha1*0201, beta1*0302) and (alpha1*0201, beta1*0303)Q73336570
Natural killer cell depletion by anti-asialo GM1 antiserum treatment enhances human hematopoietic stem cell engraftment in NOD/Shi-scid miceQ73375214
Development of Insulitis and Diabetes in B Cell-Deficient NOD MiceQ73501288
Variation and trends in incidence of childhood diabetes in Europe. EURODIAB ACE Study GroupQ73639505
Dual overlapping peptides recognized by insulin peptide B:9-23 T cell receptor AV13S3 T cell clones of the NOD mouseQ73650639
Prevention of onset in an insulin-dependent diabetes mellitus model, NOD mice, by oral feeding of Lactobacillus caseiQ73699745
beta2 microglobulin-deficient (B2m(null)) NOD/SCID mice are excellent recipients for studying human stem cell functionQ73783230
Heterogeneity of type I diabetes: analysis of monozygotic twins in Great Britain and the United StatesQ73795625
Islet cell autoimmunity in NOD mice transgenic for HLA-DQ8 and lacking I-Ag7Q74414686
Major DQ8-restricted T-cell epitopes for human GAD65 mapped using human CD4, DQA1*0301, DQB1*0302 transgenic IA(null) NOD miceQ74607783
B cell specificity contributes to the outcome of diabetes in nonobese diabetic miceQ77136854
Intrinsic in vitro abnormalities in dendritic cell generation caused by non-MHC non-obese diabetic genesQ77899232
I-Ag7-mediated antigen presentation by B lymphocytes is critical in overcoming a checkpoint in T cell tolerance to islet beta cells of nonobese diabetic miceQ77967366
Insulin expression levels in the thymus modulate insulin-specific autoreactive T-cell tolerance: the mechanism by which the IDDM2 locus may predispose to diabetesQ78014697
Diabetogenic T cells are primed both in pancreatic and gut-associated lymph nodes in NOD miceQ79318828
Peritoneal B cells govern the outcome of diabetes in non-obese diabetic miceQ80442791
On the pathogenicity of autoantigen-specific T-cell receptorsQ80770958
Toll-like receptor 2 senses beta-cell death and contributes to the initiation of autoimmune diabetesQ80813712
Evidence for an enhanced adhesion of DC to fibronectin and a role of CCL19 and CCL21 in the accumulation of DC around the pre-diabetic islets in NOD miceQ80942355
The rising incidence of childhood type 1 diabetes and reduced contribution of high-risk HLA haplotypesQ80972975
Dendritic cells and macrophages are essential for the retention of lymphocytes in (peri)-insulitis of the nonobese diabetic mouse: a phagocyte depletion studyQ81282208
Small intestinal enteropathy in non-obese diabetic mice fed a diet containing wheatQ81649672
P921main subjectobesityQ12174
P304page(s)76-88
P577publication date2015-09-21
P1433published inJournal of AutoimmunityQ15716783
P1476titleThe importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes
P478volume66

Reverse relations

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