Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes

scientific article published on 27 July 2020

Genome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S42255-020-0254-1
P698PubMed publication ID32719542

P50authorDouglas A. MeltonQ3038025
Erica P CaiQ97905927
Peng YiQ97905932
Yuki IshikawaQ55979332
Nayara Carvalho LeiteQ60732717
S KisslerQ73661227
Celia A. SchifferQ87706687
P2093author name stringWei Zhang
Jian Li
Shurong Hou
Jennifer Hollister-Lock
Nese Kurt Yilmaz
Badr Kiaf
P2860cites workIdentification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factorsQ22008465
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetesQ24632382
Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysisQ24658203
The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) miceQ24670319
FAD-binding site and NADP reactivity in human renalase: a new enzyme involved in blood pressure regulationQ27670535
Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinaseQ27938837
Generation of functional human pancreatic β cells in vitroQ28249536
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosisQ28306950
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetesQ28506402
Charting cellular identity during human in vitro β-cell differentiationQ91865409
β-Cell Stress Shapes CTL Immune Recognition of Preproinsulin Signal Peptide by Posttranscriptional Regulation of Endoplasmic Reticulum Aminopeptidase 1Q92379190
An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 DiabetesQ92626522
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetesQ28575190
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathwayQ29547371
Genome-scale CRISPR-Cas9 knockout screening in human cellsQ29616044
Evidence of gene-gene interaction and age-at-diagnosis effects in type 1 diabetesQ30416530
Metabolic function for human renalase: oxidation of isomeric forms of β-NAD(P)H that are inhibitory to primary metabolismQ33112688
Renalase prevents AKI independent of amine oxidase activityQ33660611
Pancreatic islet-specific T-cell clones from nonobese diabetic miceQ34313103
Identification of a receptor for extracellular renalaseQ34473401
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screeningQ34553929
Improved vectors and genome-wide libraries for CRISPR screeningQ35215629
The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetesQ35787117
Are insights gained from NOD mice sufficient to guide clinical translation? Another inconvenient truthQ36766166
Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in miceQ36862098
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cellsQ38331321
The catalytic function of renalase: A decade of phantomsQ38434446
Inherent ER stress in pancreatic islet β cells causes self-recognition by autoreactive T cells in type 1 diabetesQ38771484
Endoplasmic reticulum stress in beta cells and autoimmune diabetesQ38975660
Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasomeQ39299566
Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes MellitusQ39998473
NIT-1, a Pancreatic β-Cell Line Established From a Transgenic NOD/Lt MouseQ41678350
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichmentsQ44012277
Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouseQ44286381
Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes.Q46027530
The serum protein renalase reduces injury in experimental pancreatitisQ47637402
Low HLA binding of diabetes-associated CD8+ T-cell epitopes is increased by post translational modifications.Q52644342
Modifying Enzymes are Elicited by ER Stress, Generating Epitopes that are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.Q52719485
Report of the Key Opinion Leaders Meeting on Stem Cell-derived Beta CellsQ57173754
Therapies to Suppress β Cell Autoimmunity in Type 1 DiabetesQ58773667
Following a diabetogenic T cell from genesis through pathogenesisQ70488192
New inhibitor of monoamine oxidaseQ79080187
Peripherally induced regulatory T cells contribute to the control of autoimmune diabetes in the NOD mouse modelQ88232904
The challenge of modulating β-cell autoimmunity in type 1 diabetesQ90350445
Generation of hypoimmunogenic human pluripotent stem cellsQ91651405
Hypoimmunogenic derivatives of induced pluripotent stem cells evade immune rejection in fully immunocompetent allogeneic recipientsQ91691968
P921main subjectCRISPRQ412563
P577publication date2020-07-27
P1433published inNature MetabolismQ96320741
P1476titleGenome-scale in vivo CRISPR screen identifies RNLS as a target for beta cell protection in type 1 diabetes

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Q98205329Protecting β-cells in type 1 diabetescites workP2860

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