Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies

scientific article

Long-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.2337/DB12-0098
P932PMC publication ID3478559
P698PubMed publication ID22751694
P5875ResearchGate publication ID228103606

P50authorDouglas KlineQ90879576
Roland TischQ97091835
Bo WangQ97093714
Ramiro DizQ114526142
P2093author name stringLi Li
Zuoan Yi
Aaron J Martin
Yves Maurice Morillon
P2860cites workCentral role of defective interleukin-2 production in the triggering of islet autoimmune destructionQ24650734
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
Genetics, pathogenesis and clinical interventions in type 1 diabetesQ28281029
The CD4-associated tyrosine kinase p56lck is required for lymphocyte chemoattractant factor-induced T lymphocyte migrationQ28293638
Suppression of ongoing T cell-mediated autoimmunity by peptide-MHC class II dimer vaccinationQ33727390
Anti-CD3 therapy permits regulatory T cells to surmount T cell receptor–specified peripheral niche constraintsQ34096519
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells.Q53859655
Cyclosporin increases the rate and length of remissions in insulin-dependent diabetes of recent onset. Results of a multicentre double-blind trial.Q53885179
Mechanisms in CD4 antibody-mediated transplantation tolerance: kinetics of induction, antigen dependency and role of regulatory T cells.Q54193778
TOLERANCE AND SUPPRESSION IN A PRIMED IMMUNE SYSTEM1Q61651701
In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitisQ67296143
Plasminogen activators and tumor development in the human colon: activity levels in normal mucosa, adenomatous polyps, and adenocarcinomasQ69204552
Following a diabetogenic T cell from genesis through pathogenesisQ70488192
Insulin-dependent diabetes mellitusQ71046915
The role of CD8+ T cells in the initiation of insulin-dependent diabetes mellitusQ71420898
Nondepleting anti-CD4 has an immediate action on diabetogenic effector cells, halting their destruction of pancreatic beta cellsQ74108273
A key role for TGF-beta signaling to T cells in the long-term acceptance of allograftsQ81039592
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetesQ81690799
Insulin needs after CD3-antibody therapy in new-onset type 1 diabetesQ34428346
"Infectious" transplantation tolerance.Q34726892
Reprogramming the immune system: co-receptor blockade as a paradigm for harnessing tolerance mechanismsQ34793904
Sustained suppression by Foxp3+ regulatory T cells is vital for infectious transplantation toleranceQ35237468
Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trialQ35321191
Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic miceQ36380895
CD4+CD25+ T regulatory cells dependent on ICOS promote regulation of effector cells in the prediabetic lesionQ36399063
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetesQ36403481
Ligation of the CD4 receptor induces activation-independent down-regulation of L-selectinQ36432195
Human immunodeficiency virus type 1 gp120 reprogramming of CD4+ T-cell migration provides a mechanism for lymphadenopathyQ37191908
Type 1 diabetes development requires both CD4+ and CD8+ T cells and can be reversed by non-depleting antibodies targeting both T cell populations.Q37425120
Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitusQ40581531
Evidence for the role of CD8+ cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice.Q41487658
Emerging roles for the TGFbeta family in pancreatic beta-cell homeostasisQ42113167
The induction of skin graft tolerance in major histocompatibility complex-mismatched or primed recipients: primed T cells can be tolerized in the periphery with anti-CD4 and anti-CD8 antibodiesQ43414853
Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell cloneQ44534362
The use of a non-depleting anti-CD4 monoclonal antibody to re-establish tolerance to beta cells in NOD mice.Q44587253
Dynamic reorganization of chemokine receptors, cholesterol, lipid rafts, and adhesion molecules to sites of CD4 engagementQ45303209
Prevention of early loss of transplanted islets in the liver of mice by adenosine.Q45936359
TGF-beta1 alters APC preference, polarizing islet antigen responses toward a Th2 phenotypeQ46431455
Murine antithymocyte globulin therapy alters disease progression in NOD mice by a time-dependent induction of immunoregulationQ46881246
Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplantsQ47644499
TGF-beta-dependent mechanisms mediate restoration of self-tolerance induced by antibodies to CD3 in overt autoimmune diabetesQ47667692
Interleukin-4 deficiency does not exacerbate disease in NOD miceQ47690788
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivs 3.0 UnportedQ19125045
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P304page(s)2871-2880
P577publication date2012-06-29
P1433published inDiabetesQ895262
P1476titleLong-term remission of diabetes in NOD mice is induced by nondepleting anti-CD4 and anti-CD8 antibodies
P478volume61

Reverse relations

cites work (P2860)
Q63246493Anti-CD8 monoclonal antibody-mediated depletion alters the phenotype and behavior of surviving CD8+ T cells
Q37351576Anti-coreceptor therapy drives selective T cell egress by suppressing inflammation-dependent chemotactic cues
Q42737518Antibody Binding to CD4 Induces Rac GTPase Activation and Alters T Cell Migration
Q90324457Dipeptidyl peptidase-4(DPP-4) inhibitors: promising new agents for autoimmune diabetes
Q38063547Emerging immune therapies in type 1 diabetes and pancreatic islet transplantation
Q45700874Fasting and meal-stimulated residual beta cell function is positively associated with serum concentrations of proinflammatory cytokines and negatively associated with anti-inflammatory and regulatory cytokines in patients with longer term type 1 dia
Q37088180Pathogenic mechanisms in type 1 diabetes: the islet is both target and driver of disease
Q37351448Persistent suppression of type 1 diabetes by a multicomponent vaccine containing a cholera toxin B subunit-autoantigen fusion protein and complete Freund's adjuvant
Q38384138Reestablishing T Cell Tolerance by Antibody-Based Therapy in Type 1 Diabetes
Q58711931Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells
Q37342952Targeted suppression of autoreactive CD8(+) T-cell activation using blocking anti-CD8 antibodies.
Q34983677Testing agents for prevention or reversal of type 1 diabetes in rodents
Q35787117The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes
Q87135143The new insights from DPP-4 inhibitors: their potential immune modulatory function in autoimmune diabetes
Q58773667Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes
Q37381434Thymic development of autoreactive T cells in NOD mice is regulated in an age-dependent manner

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