HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2.

scientific article

HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0198-8859(01)00308-1
P698PubMed publication ID11600216

P2093author name stringNotkins AL
David CS
Govindarajan R
Marietta EV
Deng YJ
Abraham RS
Kudva YC
P2860cites workT-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agentsQ27485358
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinomaQ28244557
A genome-wide search for human type 1 diabetes susceptibility genesQ28247197
Autoantigens IA-2 and GAD in Type I (insulin-dependent) diabetesQ33535234
Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mappingQ35764760
Determinant spreading of T helper cell 2 (Th2) responses to pancreatic islet autoantigensQ36380993
Isolation, sequence and expression of a novel mouse brain cDNA, mIA-2, and its relatedness to members of the protein tyrosine phosphatase familyQ36728856
Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.Q40857730
T-cell lines reactive to an immunodominant epitope of the tyrosine phosphatase-like autoantigen IA-2 in type 1 diabetesQ40871541
Genetic analysis of autoimmune diseaseQ40980040
Detection of cell-mediated immunity in Type I diabetes mellitus☆Q44769632
HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitusQ46138865
Immune response to glutamic acid decarboxylase correlates with insulitis in non-obese diabetic mice.Q55066037
Induction of a non-encephalitogenic type 2 T helper-cell autoimmune responsein multiple sclerosis after administration of an altered peptide ligand ina placebo-controlled, randomized phase II trialQ57911995
Insulin-dependent diabetes mellitusQ71046915
Autoantibodies to IA-2 not detected in NOD mice or BB ratsQ71736400
Early Th1 response in unprimed nonobese diabetic mice to the tyrosine phosphatase-like insulinoma-associated protein 2, an autoantigen in type 1 diabetesQ73306750
Non-major histocompatibility complex dependent variations in lymphocyte activity between inbred mouse strains susceptible to various autoimmune diseasesQ73969863
T cell recognition of human pre-proinsulin peptides depends on the polymorphism at HLA DQ locus: a study using HLA DQ8 and DQ6 transgenic miceQ74074376
Islet-specific expression of IL-10 promotes diabetes in nonobese diabetic mice independent of Fas, perforin, TNF receptor-1, and TNF receptor-2 moleculesQ74183244
Endogenous immune response to glutamic acid decarboxylase (GAD67) in NOD mice is modulated by adjuvant immunotherapyQ77759650
Standardization of T-cell assays in Type I diabetes. Immunology of Diabetes Society T-cell CommitteeQ77762913
T cell reactivity to DR*0401- and DQ*0302-binding peptides of the putative autoantigen IA-2 in type 1 diabetesQ77904225
NOD background genes influence T cell responses to GAD 65 in HLA-DQ8 transgenic miceQ78059978
P433issue10
P304page(s)1099-1105
P577publication date2001-10-01
P1433published inHuman ImmunologyQ15709955
P1476titleHLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2.
P478volume62

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cites work (P2860)
Q35583448A comprehensive guide to antibody and T-cell responses in type 1 diabetes.
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Q36441606Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes
Q35120359Lessons for human diabetes from experimental mouse models
Q44189001Modulation of insulitis and type 1 diabetes by transgenic HLA-DR3 and DQ8 in NOD mice lacking endogenous MHC class II.
Q33450214Prediction of HLA-DQ8beta cell peptidome using a computational program and its relationship to autoreactive T cells
Q36012386Spontaneous myocarditis mimicking human disease occurs in the presence of an appropriate MHC and non-MHC background in transgenic mice.
Q35702538T-cell epitopes in type 1 diabetes
Q35787117The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes
Q36755911Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes
Q38808868Type 1 diabetes associated HLA-DQ2 and DQ8 molecules are relatively resistant to HLA-DM mediated release of invariant chain-derived CLIP peptides
Q35878811What can the HLA transgenic mouse tell us about autoimmune diabetes?