Type 1 diabetes associated HLA-DQ2 and DQ8 molecules are relatively resistant to HLA-DM mediated release of invariant chain-derived CLIP peptides

scientific article published on 28 December 2015

Type 1 diabetes associated HLA-DQ2 and DQ8 molecules are relatively resistant to HLA-DM mediated release of invariant chain-derived CLIP peptides is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/EJI.201545942
P932PMC publication ID4828309
P698PubMed publication ID26707565

P50authorEduardo Reyes-VargasQ56722061
P2093author name stringXiao He
Brant Rudd
Hernando Escobar
Peter E Jensen
Alan L Rockwood
Julio C Delgado
Zemin Zhou
P2860cites workThe structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3Q24303524
T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agentsQ27485358
Crystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide SelectionQ27675568
Structural and Functional Studies of trans -Encoded HLA-DQ2.3 (DQA1*03:01/DQB1*02:01) Protein MoleculeQ27677454
Genetics of type 1 diabetes mellitusQ28215982
The peptide binding motif of the disease associated HLA-DQ (alpha 1* 0501, beta 1* 0201) moleculeQ28296958
Enhanced dissociation of HLA-DR-bound peptides in the presence of HLA-DMQ28613111
Production of high-titer helper-free retroviruses by transient transfectionQ29547802
HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium familiesQ30411842
Genetics of type 1 diabetes: what's next?Q30431554
Navigating diabetes-related immune epitope data: resources and tools provided by the Immune Epitope Database (IEDB)Q30843737
Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding registerQ33934705
Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexesQ34028384
Towards a systems understanding of MHC class I and MHC class II antigen presentation.Q34029353
Dissociation of peripheral T cell responses from thymocyte negative selection by weak agonists supports a spare receptor model of T cell activationQ34048781
Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DMQ34083338
Exosome-driven antigen transfer for MHC class II presentation facilitated by the receptor binding activity of influenza hemagglutininQ34147894
On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetesQ34150236
Autoreactive T cells specific for insulin B:11-23 recognize a low-affinity peptide register in human subjects with autoimmune diabetesQ34384116
Peptide binding characteristics of the coeliac disease-associated DQ(alpha1*0501, beta1*0201) moleculeQ34392038
ZnT8-Specific CD4+ T cells display distinct cytokine expression profiles between type 1 diabetes patients and healthy adultsQ34580119
The nonconventional MHC class II molecule DM governs diabetes susceptibility in NOD miceQ34590244
Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8Q34936409
Extreme genetic risk for type 1A diabetesQ35024527
Specificity and detection of insulin-reactive CD4+ T cells in type 1 diabetes in the nonobese diabetic (NOD) mouseQ35288506
High vaccination efficiency of low-affinity epitopes in antitumor immunotherapy.Q35631830
Antigen targets of type 1 diabetes autoimmunityQ35852999
Expression and crystallization of the complex of HLA-DR2 (DRA, DRB1*1501) and an immunodominant peptide of human myelin basic proteinQ36322630
HLA and autoimmune diseases: Type 1 diabetes (T1D) as an exampleQ36399107
Weak proinsulin peptide-major histocompatibility complexes are targeted in autoimmune diabetes in miceQ36756575
Dominance of an alternative CLIP sequence in the celiac disease associated HLA-DQ2 moleculeQ36800315
Recent advances in antigen processing and presentationQ36945533
The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilingsQ37249406
HLA-Class II in Latin American patients with type 1 diabetesQ37766369
Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 DiabetesQ38134730
Type 1 diabetes-associated HLA-DQ8 transdimer accommodates a unique peptide repertoireQ39425320
Gluten-specific T cells cross-react between HLA-DQ8 and the HLA-DQ2α/DQ8β transdimerQ39455520
The rare HLA-DQA1*03-DQB1*02 haplotype confers susceptibility to type 1 diabetes in whites and is preferentially associated with early clinical disease onset in male subjectsQ39547025
Function of DQ2 and DQ8 as HLA susceptibility molecules in celiac diseaseQ40579895
Naturally processed and presented epitopes of the islet cell autoantigen IA-2 eluted from HLA-DR4.Q40857730
Presentation of abundant endogenous class II DR-restricted antigens by DM-negative B cell lines.Q41118681
Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cellsQ41440525
Low avidity recognition of self-antigen by T cells permits escape from central tolerance.Q41671634
Defective presentation of endogenous antigen by a cell line expressing class I moleculesQ41736911
An insertion mutant in DQA1*0501 restores susceptibility to HLA-DM: implications for disease associations.Q42873027
HLA-DQ8 transgenic and NOD mice recognize different epitopes within the cytoplasmic region of the tyrosine phosphatase-like molecule, IA-2.Q43766136
Structural factors contributing to DM susceptibility of MHC class II/peptide complexesQ44187666
Human leukocyte antigen class II and type 1 diabetes in Latin America: a combined meta-analysis of association and family-based studiesQ45136679
Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vectorQ45874327
Th1 and Th2 cell responses of type 1 diabetes patients and healthy controls to human heat-shock protein 60 peptides AA437-460 and AA394-408.Q46800301
T cells distinguish MHC-peptide complexes formed in separate vesicles and edited by H2-DM.Q47765737
Utility of characteristic QTOF MS/MS fragmentation for MHC class I peptides.Q51590500
The importance of CTLA-4 polymorphism and human leukocyte antigen genotype for the induction of diabetes-associated cytokine response in healthy school children.Q53537862
Persistent T cell anergy in human type 1 diabetes.Q54070212
Elevated Lymphocyte Expression of CLIP Is Associated with Type 1 Diabetes and May Be a Useful Marker of Autoimmune SusceptibilityQ57229664
An autoantigenic T cell epitope forms unstable complexes with class II MHC: a novel route for escape from tolerance inductionQ72105874
A europium fluoroimmunoassay for measuring binding of antigen to class II MHC glycoproteinsQ72888222
Proliferative responses to selected peptides of IA-2 in identical twins discordant for Type 1 diabetesQ73925993
T cell proliferative responses of type 1 diabetes patients and healthy individuals to human hsp60 and its peptidesQ74520528
HLA-DR binding analysis of peptides from islet antigens in IDDMQ77349167
Production and purification of a recombinant human hsp60 epitope using the cellulose-binding domain in Escherichia coliQ77471886
Immunological efficacy of heat shock protein 60 peptide DiaPep277 therapy in clinical type I diabetesQ81113817
IFN-gamma and IL-10 islet-antigen-specific T cell responses in autoantibody-negative first-degree relatives of patients with type 1 diabetesQ84006136
Unconventional recognition of peptides by T cells and the implications for autoimmunityQ84943150
P433issue4
P407language of work or nameEnglishQ1860
P921main subjecttype-1 diabetesQ124407
P304page(s)834-845
P577publication date2015-12-28
P1433published inEuropean Journal of ImmunologyQ5412727
P1476titleType 1 diabetes associated HLA-DQ2 and DQ8 molecules are relatively resistant to HLA-DM mediated release of invariant chain-derived CLIP peptides
P478volume46

Reverse relations

cites work (P2860)
Q93020630Class II MHC antigen processing in immune tolerance and inflammation
Q93360218Distinct editing functions of natural HLA-DM allotypes impact antigen presentation and CD4+ T cell activation
Q92707282Epitope Selection for HLA-DQ2 Presentation: Implications for Celiac Disease and Viral Defense
Q92859001HLA-DM catalytically enhances peptide dissociation by sensing peptide-MHC class II interactions throughout the peptide-binding cleft
Q26741035Human leukocyte Antigen-DM polymorphisms in autoimmune diseases
Q39214326Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation.
Q39175672Peptidomic analysis of type 1 diabetes associated HLA-DQ molecules and the impact of HLA-DM on peptide repertoire editing.
Q34676583The melting pot of the MHC II peptidome
Q51079315Unraveling the structural basis for the unusually rich association of human leukocyte antigen DQ2.5 with class-II-associated invariant chain peptides.

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