Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism

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Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2003PNAS..100.8292C
P356DOI10.1073/PNAS.1532175100
P932PMC publication ID166222
P698PubMed publication ID12829789
P5875ResearchGate publication ID10687742

P50authorMarika CharalambousQ43142261
Andrew WardQ48975691
P2093author name stringWilliam R Bennett
Francesca Mackenzie
Florentia M Smith
Tracey E Crew
P2860cites workRole for the adaptor protein Grb10 in the activation of AktQ24537512
Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesisQ24554440
Capturing genes encoding membrane and secreted proteins important for mouse developmentQ24563626
Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its functionQ24563627
Genomic sequencingQ24594942
Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinasesQ28268392
Genomic imprinting in mammalian development: a parental tug-of-warQ28278146
Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signalingQ28289183
Assignment of growth factor receptor-bound protein 10 (GRB10) to human chromosome 7p11.2-p12Q28306122
Scatter factor/hepatocyte growth factor is essential for liver developmentQ28504542
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb budQ28506228
mGrb10 interacts with Nedd4Q28508597
Specific inhibition by hGRB10zeta of insulin-induced glycogen synthase activation: evidence for a novel signaling pathwayQ28565441
Overgrowth of a mouse model of the Simpson-Golabi-Behmel syndrome is independent of IGF signalingQ28586391
The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblastsQ28591965
Role of insulin-like growth factors in embryonic and postnatal growthQ29620034
Abnormal gene expression in cloned mice derived from embryonic stem cell and cumulus cell nucleiQ34190380
Silver-Russell syndrome: a dissection of the genetic aetiology and candidate chromosomal regionsQ34465575
Identification of the Meg1/Grb10 imprinted gene on mouse proximal chromosome 11, a candidate for the Silver-Russell syndrome geneQ35793734
Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementationQ35935159
Simple and efficient production of embryonic stem cell-embryo chimeras by cocultureQ36306244
The cloning of Grb10 reveals a new family of SH2 domain proteinsQ36701969
Structural-proliferative units and organ growth: effects of insulin-like growth factor 2 on the growth of colon and skin.Q42436704
The role of mGrb10alpha in insulin-like growth factor I-mediated growthQ42835170
Faithful expression of imprinted genes in cloned mice.Q44438069
Gene trapping methods for the identification and functional analysis of cell surface proteins in miceQ46085169
Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashionQ47851255
Epigenetic instability in ES cells and cloned miceQ48882976
Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells.Q52013513
Imprinting of Igf2 and H19 from a 130 kb YAC transgene.Q52192416
Growth-promoting interaction of IGF-II with the insulin receptor during mouse embryonic development.Q52192889
A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.Q52241373
Parental imprinting of the mouse insulin-like growth factor II gene.Q55052428
Time of initiation and site of action of the mouse chromosome 11 imprinting effectsQ71441501
Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo cultureQ73435273
Evidence against GRB10 as the gene responsible for Silver-Russell syndromeQ74438203
P433issue14
P407language of work or nameEnglishQ1860
P1104number of pages6
P304page(s)8292-8297
P577publication date2003-06-26
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleDisruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism
P478volume100

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cites work (P2860)
Q24652620A mono-allelic bivalent chromatin domain controls tissue-specific imprinting at Grb10
Q38028387A survey of tissue-specific genomic imprinting in mammals
Q45992309Adaptations in placental nutrient transfer capacity to meet fetal growth demands depend on placental size in mice.
Q43233499Adaptations in placental phenotype support fetal growth during undernutrition of pregnant mice.
Q36294476Adapter protein connections: the MRL and Grb7 protein families
Q35102519Altered expression of the imprinted transcription factor PLAGL1 deregulates a network of genes in the human IUGR placenta
Q47273848An enhancer element at the Igf2/H19 locus drives gene expression in both imprinted and non-imprinted tissues.
Q36808158An imprinted gene network that controls mammalian somatic growth is down-regulated during postnatal growth deceleration in multiple organs
Q33976541Analysis of imprinted gene expression in normal fertilized and uniparental preimplantation porcine embryos
Q34793925Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1 genes
Q35754088Assisted reproduction causes placental maldevelopment and dysfunction linked to reduced fetal weight in mice.
Q34083377Association of maternally inherited GNAS alleles with African-American male birth weight
Q33402663Brain-derived neurotrophic factor modulation of Kv1.3 channel is disregulated by adaptor proteins Grb10 and nShc
Q35536252Carrageenan Inhibits Insulin Signaling through GRB10-mediated Decrease in Tyr(P)-IRS1 and through Inflammation-induced Increase in Ser(P)307-IRS1
Q33285306Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7.
Q54583340Cell signaling. New mTOR targets Grb attention.
Q30466805Child health, developmental plasticity, and epigenetic programming
Q41473798Combinatorial epigenetic mechanisms and efficacy of early breast cancer inhibition by nutritive botanicals
Q36436496Complementation hypothesis: the necessity of a monoallelic gene expression mechanism in mammalian development.
Q36312121DNA methylation at differentially methylated regions of imprinted genes is resistant to developmental programming by maternal nutrition
Q28729719DNA methylation differences at growth related genes correlate with birth weight: a molecular signature linked to developmental origins of adult disease?
Q51348868Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.
Q92740739Detailed analysis of paternal knockout Grb10 mice suggests effects on stability of social behavior, rather than social dominance
Q28589885Development of a novel cysteine sulfinic Acid decarboxylase knockout mouse: dietary taurine reduces neonatal mortality
Q27315822Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup
Q57230563Dietary composition programmes placental phenotype in mice
Q64099717Differences in expression rather than methylation at placenta-specific imprinted loci is associated with intrauterine growth restriction
Q46148910Disproportional effects of Igf2 knockout on placental morphology and diffusional exchange characteristics in the mouse.
Q36410666Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosis
Q24338677Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling
Q24632557Distinct physiological and behavioural functions for parental alleles of imprinted Grb10
Q37332419Dual ablation of Grb10 and Grb14 in mice reveals their combined role in regulation of insulin signaling and glucose homeostasis
Q34994085Dynamic expression of imprinted genes associates with maternally controlled nutrient allocation during maize endosperm development.
Q35599540Dysregulation of methylation and expression of imprinted genes in oocytes and reproductive tissues in mice of advanced maternal age
Q48337205ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes
Q41987353ERK Signals: Scaffolding Scaffolds?
Q52660446Effects of Cadmium Exposure on DNA Methylation at Imprinting Control Regions and Genome-Wide in Mothers and Newborn Children.
Q33364216Evolution of genomic imprinting with biparental care: implications for Prader-Willi and Angelman syndromes
Q54634225Expression and functional analysis of genes deregulated in mouse placental overgrowth models: Car2 and Ncam1.
Q50794831Expression of delta-like 1 homologue and insulin-like growth factor 2 through epigenetic regulation of the genes during development of mouse molar.
Q37059585FGFR3 gene mutation plus GRB10 gene duplication in a patient with achondroplasia plus growth delay with prenatal onset.
Q39225058FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia
Q50703897Footprints of recent selection and variability in breed composition in the Göttingen Minipig genome.
Q37043802Frequency and characterization of DNA methylation defects in children born SGA.
Q24300609GRB10 binds to LRP6, the Wnt co-receptor and inhibits canonical Wnt signaling pathway
Q27312725Gene dosage effects of the imprinted delta-like homologue 1 (dlk1/pref1) in development: implications for the evolution of imprinting
Q36730925Gene-environment interactions and epigenetic basis of human diseases
Q55279758Genome-wide DNA methylation patterns of bovine blastocysts derived from in vivo embryos subjected to in vitro culture before, during or after embryonic genome activation.
Q36436558Genome-wide survey of imprinted genes
Q91596236Genomic imprinting and its effects on postnatal growth and adult metabolism
Q37715275Genomic imprinting in development, growth, behavior and stem cells
Q36421141Genomic imprinting of Dopa decarboxylase in heart and reciprocal allelic expression with neighboring Grb10.
Q35105543Genomic imprinting of Grb10: coadaptation or conflict?
Q36083462Genomic imprinting: cis-acting sequences and regional control
Q37172147Genomic organization and control of the grb7 gene family
Q36131371Grb10 and Grb14: enigmatic regulators of insulin action--and more?
Q40126556Grb10 and active Raf-1 kinase promote Bad-dependent cell survival
Q42456312Grb10 deletion enhances muscle cell proliferation, differentiation and GLUT4 plasma membrane translocation
Q38178194Grb10 is a dual regulator of receptor tyrosine kinase signaling
Q38953915Grb10 is involved in BCR-ABL-positive leukemia in mice.
Q40325493Grb10 mediates insulin-stimulated degradation of the insulin receptor: a mechanism of negative regulation
Q40642763Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action
Q45864153Growth factor receptor-bound protein 14: a potential new gene associated with oocyte competence.
Q47273227Growth perturbations in a phenotype with rapid fetal growth preceding preterm labor and term birth.
Q44039759Growth receptor binding protein 10 inhibits glucose-stimulated insulin release from pancreatic β-cells associated with suppression of the insulin/insulin-like growth factor-1 signalling pathway
Q36237307HuR inhibits apoptosis by amplifying Akt signaling through a positive feedback loop
Q52688996Human exposure to flame-retardants is associated with aberrant DNA methylation at imprinted genes in sperm.
Q53501508Impact of Abnormal DNA Methylation of Imprinted Loci on Human Spontaneous Abortion.
Q36436588Imprinted genes in placental growth and obstetric disorders
Q37543706Imprinting and extraembryonic tissues-mom takes control
Q34107651Improved glucose homeostasis and enhanced insulin signalling in Grb14-deficient mice
Q52644142Impulsive Choice in Mice Lacking Paternal Expression of Grb10 Suggests Intragenomic Conflict in Behavior.
Q92221257Insights into body size variation in cetaceans from the evolution of body-size-related genes
Q34407440Insulin and insulin-like growth factor 1 receptors are required for normal expression of imprinted genes
Q34567123Interactions between imprinting effects in the mouse
Q36436492Interactions between imprinting effects: summary and review
Q37909236Is there a genomically imprinted social brain?
Q36742624Maternal Diet during Pregnancy Induces Gene Expression and DNA Methylation Changes in Fetal Tissues in Sheep
Q33789139Maternal psychosocial stress during pregnancy and placenta weight: evidence from a national cohort study
Q37336786Maternal vitamin D depletion alters DNA methylation at imprinted loci in multiple generations
Q47172204Maternally-inherited Grb10 reduces placental size and efficiency
Q35670415Mest but Not MiR-335 Affects Skeletal Muscle Growth and Regeneration
Q37479026Methylation Status of H19/IGF2 Differentially Methylated Region in in vitro Human Blastocysts Donated by Healthy Couples.
Q35950176Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life
Q21131281Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances
Q34399056Molecular characterization of the Neuronatin gene in the porcine placenta
Q35639252Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice.
Q24632761Nedd4 controls animal growth by regulating IGF-1 signaling
Q57074714Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice
Q36410769New role for Grb10 signaling in the pancreas
Q36177520Peripheral disruption of the Grb10 gene enhances insulin signaling and sensitivity in vivo
Q37712366Perturbations to the IGF1 growth pathway and adult energy homeostasis following disruption of mouse chromosome 12 imprinting.
Q35370616Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling
Q28655490Post-natal imprinting: evidence from marsupials
Q42873918Postnatal growth restriction and gene expression changes in a mouse model of fetal alcohol syndrome.
Q28285118Psychosis and autism as diametrical disorders of the social brain
Q35881887Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain
Q26849720Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins
Q45265601Restricted development of mouse triploid fetuses with disorganized expression of imprinted genes
Q37317744Review paper: a review of the pathology of abnormal placentae of somatic cell nuclear transfer clone pregnancies in cattle, sheep, and mice.
Q37534656Somatic Cell Nuclear Transfer Followed by CRIPSR/Cas9 Microinjection Results in Highly Efficient Genome Editing in Cloned Pigs
Q27679785Structural Basis for the Interaction of the Adaptor Protein Grb14 with Activated Ras
Q27656836Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14
Q27665387Structural basis for the interaction between the growth factor-binding protein GRB10 and the E3 ubiquitin ligase NEDD4
Q57278462Síndrome de Silver-Russell: relato de caso
Q51922783Temporal and spatial expression of a growth-regulated network of imprinted genes in growth plate.
Q43093699Testosterone modulates gene expression pathways regulating nutrient accumulation, glucose metabolism and protein turnover in mouse skeletal muscle.
Q39698172The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-kappaB signaling pathways.
Q38779863The evolving landscape of imprinted genes in humans and mice: Conflict among alleles, genes, tissues, and kin.
Q33628787The importance of imprinting in the human placenta.
Q33928657The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.
Q27007861The origin and evolution of genomic imprinting and viviparity in mammals
Q28083223The role and interaction of imprinted genes in human fetal growth
Q34426232The role of genomic imprinting in biology and disease: an expanding view
Q35295496The role of imprinted genes in fetal growth abnormalities
Q26770682The role of small adaptor proteins in the control of oncogenic signaling driven by tyrosine kinases in human cancer
Q30653788Tissue-specific regulation and function of Grb10 during growth and neuronal commitment
Q38246516What does genetics tell us about imprinting and the placenta connection?
Q21145804ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth

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