Insights into the mechanism of inhibition of CXCR4: identification of Piperidinylethanamine analogs as anti-HIV-1 inhibitors.

scientific article

Insights into the mechanism of inhibition of CXCR4: identification of Piperidinylethanamine analogs as anti-HIV-1 inhibitors. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/AAC.04654-14
P932PMC publication ID4356787
P698PubMed publication ID25583709
P5875ResearchGate publication ID270966975

P50authorKenji MaedaQ55153732
P2093author name stringHiroaki Mitsuya
Arun K Ghosh
Yasuhiro Hayashi
Debananda Das
Darshan V Desai
Simon B Chang
Navnath Gavande
P2860cites workStructures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonistsQ24619974
Molecular Shape and Medicinal Chemistry: A PerspectiveQ27659860
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracyQ28251042
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular cloneQ29547734
Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase geneQ29615351
Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexesQ29616736
Conformer generation with OMEGA: algorithm and validation using high quality structures from the Protein Databank and Cambridge Structural DatabaseQ30494222
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptorQ30832371
Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptorQ31821860
Involvement of both the V2 and V3 regions of the CCR5-tropic human immunodeficiency virus type 1 envelope in reduced sensitivity to macrophage inflammatory protein 1alphaQ33797534
Isolation of a new human retrovirus from West African patients with AIDS.Q34038984
Structural and molecular interactions of CCR5 inhibitors with CCR5.Q34494226
Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variantsQ34737640
Multiple-dose escalation study of the safety, pharmacokinetics, and biologic activity of oral AMD070, a selective CXCR4 receptor inhibitor, in human subjectsQ35879000
GluVII:06--a highly conserved and selective anchor point for non-peptide ligands in chemokine receptorsQ36570350
Potent synergistic anti-human immunodeficiency virus (HIV) effects using combinations of the CCR5 inhibitor aplaviroc with other anti-HIV drugsQ36703042
Involvement of the second extracellular loop and transmembrane residues of CCR5 in inhibitor binding and HIV-1 fusion: insights into the mechanism of allosteric inhibition.Q37071732
Lifting the lid on GPCRs: the role of extracellular loopsQ37921853
Development of novel CXCR4-based therapeuticsQ37979306
CCR5 inhibitors: emergence, success, and challengesQ38005459
Human immunodeficiency virus glycoprotein gp120 as the primary target for the antiviral action of AR177 (Zintevir).Q38339478
Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of T-cell tropic (X4) HIV-1 replicationQ38921090
Blockade of X4-tropic HIV-1 cellular entry by GSK812397, a potent noncompetitive CXCR4 receptor antagonistQ39104422
Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5.Q39202247
Proof of activity with AMD11070, an orally bioavailable inhibitor of CXCR4-tropic HIV type 1.Q39276845
Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replicationQ39469626
A low-molecular-weight inhibitor against the chemokine receptor CXCR4: a strong anti-HIV peptide T140.Q39507599
Orally bioavailable isothioureas block function of the chemokine receptor CXCR4 in vitro and in vivoQ39521135
Photolabeling identifies transmembrane domain 4 of CXCR4 as a T140 binding siteQ39821124
Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and G(alpha)(i) activation.Q40188327
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.Q41071776
Indicator cell lines for detection of primary strains of human and simian immunodeficiency virusesQ41104028
Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activitiesQ45742231
The different ways through which specificity works in orthosteric and allosteric drugsQ47577552
Comparison of Shape-Matching and Docking as Virtual Screening ToolsQ56853909
Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor LigandsQ57838214
Azamacrocyclic metal complexes as CXCR4 antagonistsQ83396529
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)1895-1904
P577publication date2015-01-12
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleInsights into the mechanism of inhibition of CXCR4: identification of Piperidinylethanamine analogs as anti-HIV-1 inhibitors
P478volume59

Reverse relations

cites work (P2860)
Q64082901Activity and structural analysis of GRL-117C: a novel small molecule CCR5 inhibitor active against R5-tropic HIV-1s
Q56700832Advances in the Development of Shape Similarity Methods and Their Application in Drug Discovery
Q45325496Chemokines and Chemokine Receptors: Accomplices for Human Immunodeficiency Virus Infection and Latency
Q36212626Development of CXCR4 modulators by virtual HTS of a novel amide-sulfamide compound library
Q27468774Membrane-associated GRP78 helps subgroup J avian leucosis virus enter cells
Q50870345Novel anti-inflammatory agents targeting CXCR4: Design, synthesis, biological evaluation and preliminary pharmacokinetic study.
Q34550666Structural Analysis of Chemokine Receptor-Ligand Interactions
Q39766459Symmetrical bis-tertiary amines as novel CXCR4 inhibitors

Search more.