| scholarly article | Q13442814 |
| P356 | DOI | 10.1074/JBC.M702311200 |
| P698 | PubMed publication ID | 17591774 |
| P50 | author | Patrick M. Sexton | Q39936838 |
| Michael W Parker | Q41147578 | ||
| Craig J Morton | Q42555164 | ||
| P2093 | author name string | Karen J Gregory | |
| Arthur Christopoulos | |||
| Vimesh A Avlani | |||
| P433 | issue | 35 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | G protein-coupled receptor | Q38173 |
| P304 | page(s) | 25677-25686 | |
| P577 | publication date | 2007-06-25 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Critical role for the second extracellular loop in the binding of both orthosteric and allosteric G protein-coupled receptor ligands | |
| P478 | volume | 282 |
| Q35643821 | A Monod-Wyman-Changeux mechanism can explain G protein-coupled receptor (GPCR) allosteric modulation |
| Q34055922 | A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway |
| Q39947679 | A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand. |
| Q35176476 | Agonist binding by the β2-adrenergic receptor: an effect of receptor conformation on ligand association-dissociation characteristics |
| Q46985701 | Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation |
| Q37311400 | Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor |
| Q37321069 | Coarse-grained modeling of allosteric regulation in protein receptors |
| Q36941174 | Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective |
| Q34517431 | Crystal structures of the M1 and M4 muscarinic acetylcholine receptors |
| Q38542934 | Current status of A1 adenosine receptor allosteric enhancers |
| Q42694873 | Distinct second extracellular loop structures of the brain cannabinoid CB(1) receptor: implication in ligand binding and receptor function |
| Q34049826 | Do crystal structures obviate the need for theoretical models of GPCRs for structure-based virtual screening? |
| Q38125563 | Emerging paradigms in GPCR allostery: implications for drug discovery |
| Q30394046 | Exploring the mechanism of F282L mutation-caused constitutive activity of GPCR by a computational study |
| Q51451305 | Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy. |
| Q33541287 | Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach |
| Q55511977 | Full rescue of an inactive olfactory receptor mutant by elimination of an allosteric ligand-gating site. |
| Q36342324 | Generation and characterization of an antagonistic monoclonal antibody against an extracellular domain of mouse DP2 (CRTH2/GPR44) receptors for prostaglandin D2. |
| Q35115637 | Identification and functional comparison of seven-transmembrane G-protein-coupled BILF1 receptors in recently discovered nonhuman primate lymphocryptoviruses |
| Q33748133 | Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias |
| Q46550812 | Identification, tissue distribution and functional characterization of the ghrelin receptor in West African lungfish, Protopterus annectens |
| Q33400428 | Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators |
| Q35606583 | Inhibition and Reversal of Microbial Attachment by an Antibody with Parasteric Activity against the FimH Adhesin of Uropathogenic E. coli |
| Q35168976 | Insights into the mechanism of inhibition of CXCR4: identification of Piperidinylethanamine analogs as anti-HIV-1 inhibitors. |
| Q37921853 | Lifting the lid on GPCRs: the role of extracellular loops |
| Q42933080 | Ligand entry and exit pathways in the beta2-adrenergic receptor |
| Q33577530 | Mapping of allosteric druggable sites in activation-associated conformers of the M2 muscarinic receptor |
| Q36430829 | Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping |
| Q34054370 | Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach |
| Q40370946 | Microscopic binding of M5 muscarinic acetylcholine receptor with antagonists by homology modeling, molecular docking, and molecular dynamics simulation |
| Q42951624 | Modeling the possible conformations of the extracellular loops in G-protein-coupled receptors |
| Q41940041 | Modulation of constitutive activity and signaling bias of the ghrelin receptor by conformational constraint in the second extracellular loop |
| Q34018861 | Molecular basis of ligand dissociation in β-adrenergic receptors |
| Q43590655 | Molecular cloning, regulation, and functional analysis of two GHS-R genes in zebrafish |
| Q34140989 | Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor |
| Q42582195 | Molecular modeling of the M3 acetylcholine muscarinic receptor and its binding site |
| Q37593696 | Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment |
| Q36776553 | Novel insights into CB1 cannabinoid receptor signaling: a key interaction identified between the extracellular-3 loop and transmembrane helix 2 |
| Q34399823 | Opportunities and challenges in the discovery of allosteric modulators of GPCRs for treating CNS disorders |
| Q34918713 | Orthosteric binding of ρ-Da1a, a natural peptide of snake venom interacting selectively with the α1A-adrenoceptor |
| Q33507142 | PEGylated dendritic unimolecular micelles as versatile carriers for ligands of G protein-coupled receptors |
| Q28473160 | Predicting drug-target interaction networks based on functional groups and biological features |
| Q49961724 | Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling. |
| Q37688232 | Rational design of dualsteric GPCR ligands: quests and promise |
| Q37070252 | Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. |
| Q26864384 | Regulation of G protein-coupled receptors by allosteric ligands |
| Q38862301 | Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding |
| Q57471905 | Role of Extracellular Loops and Membrane Lipids for Ligand Recognition in the Neuronal Adenosine Receptor Type 2A: An Enhanced Sampling Simulation Study |
| Q40932261 | Role of extracellular cysteine residues in the adenosine A2A receptor. |
| Q39341570 | Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity. |
| Q38621958 | Role of the transmembrane domain 4/extracellular loop 2 junction of the human gonadotropin-releasing hormone receptor in ligand binding and receptor conformational selection. |
| Q35763289 | Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function. |
| Q35763258 | Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation |
| Q36347742 | Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor |
| Q90332751 | Structural Features and Ligand Selectivity for 10 Intermediates in the Activation Process of β2-Adrenergic Receptor |
| Q50470980 | Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs. |
| Q24595276 | Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor |
| Q57015852 | Structure and Modeling of GPCRs: Implications for Drug Discovery |
| Q27651011 | Structure of a beta1-adrenergic G-protein-coupled receptor |
| Q35550563 | The extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity |
| Q37081904 | Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation. |
| Q53665507 | Understanding the conformation transition in the activation pathway of β2 adrenergic receptor via a targeted molecular dynamics simulation. |
| Q39819177 | VRQ397 (CRAVKY): a novel noncompetitive V2 receptor antagonist |
| Q33367388 | Virtual screening of GPCRs: an in silico chemogenomics approach |
Search more.