| scholarly article | Q13442814 |
| P50 | author | Arthur Christopoulos | Q18977850 |
| Laurence J Miller | Q96046330 | ||
| Cassandra Koole | Q114366385 | ||
| Patrick M. Sexton | Q39936838 | ||
| Denise Wootten | Q43294588 | ||
| John Simms | Q57639605 | ||
| P2860 | cites work | Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes | Q22008730 |
| beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2 | Q22253360 | ||
| IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels | Q24259024 | ||
| Molecular recognition of corticotropin-releasing factor by its G-protein-coupled receptor CRFR1 | Q24314090 | ||
| Multiple residues in the second extracellular loop are critical for M3 muscarinic acetylcholine receptor activation | Q79527348 | ||
| Structure of the human histamine H1 receptor complex with doxepin | Q24595968 | ||
| Structure of a nanobody-stabilized active state of the β(2) adrenoceptor | Q24597139 | ||
| Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds | Q24605173 | ||
| Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists | Q24619974 | ||
| Structure and function of an irreversible agonist-β(2) adrenoceptor complex | Q24620291 | ||
| Crystal structure of the β2 adrenergic receptor-Gs protein complex | Q24635327 | ||
| The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist | Q24654563 | ||
| High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor | Q24657484 | ||
| Crystal structure of rhodopsin: A G protein-coupled receptor | Q27625972 | ||
| Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand | Q27644056 | ||
| Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor | Q27647464 | ||
| Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain | Q27649890 | ||
| Molecular recognition of parathyroid hormone by its G protein-coupled receptor | Q27650193 | ||
| Structure of a beta1-adrenergic G-protein-coupled receptor | Q27651011 | ||
| Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor | Q27657999 | ||
| Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist | Q27666030 | ||
| Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction | Q27860958 | ||
| Characterization of glucagon-like peptide-1 receptor-binding determinants | Q28140350 | ||
| Identification of key residues for interaction of vasoactive intestinal peptide with human VPAC1 and VPAC2 receptors and development of a highly selective VPAC1 receptor agonist. Alanine scanning and molecular modeling of the peptide | Q28143861 | ||
| In vitro folding, functional characterization, and disulfide pattern of the extracellular domain of human GLP-1 receptor | Q28201065 | ||
| Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus | Q28201902 | ||
| The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes | Q28273497 | ||
| How many drug targets are there? | Q28276660 | ||
| Critical contributions of amino-terminal extracellular domains in agonist binding and activation of secretin and vasoactive intestinal polypeptide receptors. Studies of chimeric receptors | Q28303314 | ||
| GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cells | Q28506327 | ||
| Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions | Q29547189 | ||
| Biology of incretins: GLP-1 and GIP | Q29617302 | ||
| Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias | Q33748133 | ||
| Turn-on switch in parathyroid hormone receptor by a two-step parathyroid hormone binding mechanism. | Q34115829 | ||
| Localization of ligand-binding domains of human corticotropin-releasing factor receptor: a chimeric receptor approach | Q34428395 | ||
| G protein-coupled receptor allosterism and complexing | Q34523552 | ||
| beta-arrestin-dependent, G protein-independent ERK1/2 activation by the beta2 adrenergic receptor | Q34562493 | ||
| Importance of each residue within secretin for receptor binding and biological activity | Q34765608 | ||
| Refinement of glucagon-like peptide 1 docking to its intact receptor using mid-region photolabile probes and molecular modeling | Q34963202 | ||
| Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening. | Q35454522 | ||
| The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice | Q35733326 | ||
| Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation. | Q35999406 | ||
| Mechanisms of peptide and nonpeptide ligand binding to Class B G-protein-coupled receptors | Q36088758 | ||
| Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation. | Q37250484 | ||
| Dual role of the second extracellular loop of the cannabinoid receptor 1: ligand binding and receptor localization | Q37402780 | ||
| NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor | Q37511744 | ||
| Amphipathic helix motif: classes and properties | Q37987535 | ||
| Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling cAMP response element modulator-alpha and DUSP14. | Q38296273 | ||
| Parathyroid hormone-receptor interactions identified directly by photocross-linking and molecular modeling studies | Q38334193 | ||
| Five out of six tryptophan residues in the N-terminal extracellular domain of the rat GLP-1 receptor are essential for its ability to bind GLP-1. | Q38349901 | ||
| Functional coupling of Cys-226 and Cys-296 in the glucagon-like peptide-1 (GLP-1) receptor indicates a disulfide bond that is close to the activation pocket. | Q39651704 | ||
| The major determinant of exendin-4/glucagon-like peptide 1 differential affinity at the rat glucagon-like peptide 1 receptor N-terminal domain is a hydrogen bond from SER-32 of exendin-4. | Q39677369 | ||
| Systematic analysis of the entire second extracellular loop of the V(1a) vasopressin receptor: key residues, conserved throughout a G-protein-coupled receptor family, identified. | Q40150862 | ||
| Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2. | Q40413778 | ||
| Molecular approximation between a residue in the amino-terminal region of calcitonin and the third extracellular loop of the class B G protein-coupled calcitonin receptor | Q40553493 | ||
| Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analogues | Q40589773 | ||
| Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity | Q40663308 | ||
| The glucagon-like peptide-1 receptor binding site for the N-terminus of GLP-1 requires polarity at Asp198 rather than negative charge | Q40696352 | ||
| Multiple extracellular loop domains contribute critical determinants for agonist binding and activation of the secretin receptor | Q41190802 | ||
| Extracellular domains of the bradykinin B2 receptor involved in ligand binding and agonist sensing defined by anti-peptide antibodies | Q41237775 | ||
| The amino terminal domain of the glucagon-like peptide-1 receptor is a critical determinant of subtype specificity. | Q41251701 | ||
| Glucagon.glucagon-like peptide I receptor chimeras reveal domains that determine specificity of glucagon binding | Q41357747 | ||
| Structure-activity studies of glucagon-like peptide-1. | Q41481640 | ||
| Structural requirements for biological activity of glucagon-like peptide-I. | Q41604648 | ||
| Selectivity of agonists for the active state of M1 to M4 muscarinic receptor subtypes | Q43179420 | ||
| Two mutations in extracellular loop 2 of the human GnRH receptor convert an antagonist to an agonist. | Q43974267 | ||
| Sauvagine cross-links to the second extracellular loop of the corticotropin-releasing factor type 1 receptor | Q44005255 | ||
| The positive charge at Lys-288 of the glucagon-like peptide-1 (GLP-1) receptor is important for binding the N-terminus of peptide agonists. | Q44627982 | ||
| An agonist-like monoclonal antibody against the human beta2-adrenoceptor | Q46246949 | ||
| Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors. | Q51797215 | ||
| Spatial approximation between the amino terminus of a peptide agonist and the top of the sixth transmembrane segment of the secretin receptor. | Q51832446 | ||
| Operational models of pharmacological agonism. | Q52699226 | ||
| Localization of Ligand-Binding Domains of Human Corticotropin-Releasing Factor Receptor: A Chimeric Receptor Approach | Q55894893 | ||
| Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands | Q57838214 | ||
| Two Mutations in Extracellular Loop 2 of the Human GnRH Receptor Convert an Antagonist to an Agonist | Q58853778 | ||
| Glucagon and glucagon-like peptide 1: selective receptor recognition via distinct peptide epitopes | Q71660221 | ||
| Full activation of chimeric receptors by hybrids between parathyroid hormone and calcitonin. Evidence for a common pattern of ligand-receptor interaction | Q71742566 | ||
| The isolated N-terminal extracellular domain of the glucagon-like peptide-1 (GLP)-1 receptor has intrinsic binding activity | Q71841153 | ||
| Localization of the domains involved in ligand binding and activation of the glucose-dependent insulinotropic polypeptide receptor | Q73370227 | ||
| High potency antagonists of the pancreatic glucagon-like peptide-1 receptor | Q73596177 | ||
| Residues in the membrane-spanning and extracellular loop regions of the parathyroid hormone (PTH)-2 receptor determine signaling selectivity for PTH and PTH-related peptide | Q73853906 | ||
| The N-terminal fragment of human parathyroid hormone receptor 1 constitutes a hormone binding domain and reveals a distinct disulfide pattern | Q74061883 | ||
| P433 | issue | 6 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 3642-3658 | |
| P577 | publication date | 2011-12-06 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation | |
| P478 | volume | 287 |
| Q47145368 | A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses |
| Q27345100 | A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures |
| Q96132105 | Advances in therapeutic peptides targeting G protein-coupled receptors |
| Q37427453 | An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain. |
| Q38864019 | Characterization of signal bias at the GLP-1 receptor induced by backbone modification of GLP-1. |
| Q41597824 | Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein |
| Q50968563 | Crystal structure of the GLP-1 receptor bound to a peptide agonist. |
| Q90700746 | Deconvoluting the Molecular Control of Binding and Signaling at the Amylin 3 Receptor: RAMP3 Alters Signal Propagation through Extracellular Loops of the Calcitonin Receptor |
| Q51451305 | Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy. |
| Q49898093 | Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy. |
| Q33615669 | Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R) |
| Q28067465 | Glucagon-Like Peptide-1 and Its Class B G Protein-Coupled Receptors: A Long March to Therapeutic Successes |
| Q55354388 | High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening. |
| Q92513493 | Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury |
| Q34393487 | Insights into the structure of class B GPCRs |
| Q34683416 | Investigation of interactions at the extracellular loops of the relaxin family peptide receptor 1 (RXFP1). |
| Q28278129 | Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor |
| Q35126680 | Ligand binding pocket formed by evolutionarily conserved residues in the glucagon-like peptide-1 (GLP-1) receptor core domain |
| Q38974881 | Modulation of GLP-1 signaling as a novel therapeutic approach in the treatment of Alzheimer's disease pathology |
| Q26823392 | Molecular evolution of GPCRs: GLP1/GLP1 receptors |
| Q34140989 | Molecular mechanisms of bitopic ligand engagement with the M1 muscarinic acetylcholine receptor |
| Q58591916 | Multivalent activation of GLP-1 and Sulfonylurea receptors modulates β-cell Second Messenger Signaling and Insulin Secretion |
| Q52375459 | Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex. |
| Q36729833 | Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations |
| Q36471233 | Predicted structure of agonist-bound glucagon-like peptide 1 receptor, a class B G protein-coupled receptor |
| Q35771098 | Purslane Effect on GLP-1 and GLP-1 receptor in type 2 diabetes |
| Q38077226 | Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function. |
| Q38200333 | Recent developments in biased agonism |
| Q42571235 | Receptor Activity-modifying Proteins 2 and 3 Generate Adrenomedullin Receptor Subtypes with Distinct Molecular Properties |
| Q24563430 | Regulation of glucose homeostasis by GLP-1 |
| Q35763289 | Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function. |
| Q47849019 | Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells |
| Q28274664 | Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R) |
| Q37635253 | Structural and functional insights into the juxtamembranous amino-terminal tail and extracellular loop regions of class B GPCRs. |
| Q38644545 | Structural insight into the activation of a class B G-protein-coupled receptor by peptide hormones in live human cells. |
| Q24601619 | Structure of the human glucagon class B G-protein-coupled receptor |
| Q28276469 | The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism |
| Q90700712 | The Molecular Control of Calcitonin Receptor Signaling |
| Q38077227 | The activation of the CGRP receptor |
| Q26828940 | The class B G-protein-coupled GLP-1 receptor: an important target for the treatment of type-2 diabetes mellitus |
| Q40284076 | The peptide agonist-binding site of the glucagon-like peptide-1 (GLP-1) receptor based on site-directed mutagenesis and knowledge-based modelling |
| Q42148420 | The role of ECL2 in CGRP receptor activation: a combined modelling and experimental approach |
| Q28082755 | Transmembrane signal transduction by peptide hormones via family B G protein-coupled receptors |
| Q53282873 | Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism. |
| Q43294448 | β-Arrestin-Biased Agonists of the GLP-1 Receptor from β-Amino Acid Residue Incorporation into GLP-1 Analogues. |
Search more.