| scholarly article | Q13442814 |
| P356 | DOI | 10.1124/MOL.116.105007 |
| P698 | PubMed publication ID | 27683014 |
| P50 | author | Arthur Christopoulos | Q18977850 |
| Patrick M. Sexton | Q39936838 | ||
| Karen J. Gregory | Q42574240 | ||
| Trayder Thomas | Q64399275 | ||
| Lauren T May | Q96202346 | ||
| P2093 | author name string | Jo-Anne Baltos | |
| Paul J White | |||
| Toan D Nguyen | |||
| Anh T N Nguyen | |||
| Laura López Muñoz | |||
| P2860 | cites work | The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools | Q24248165 |
| Structure of an agonist-bound human A2A adenosine receptor | Q24296388 | ||
| Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation | Q24303747 | ||
| Adenosine receptors as therapeutic targets | Q24632095 | ||
| CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields | Q24632987 | ||
| The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist | Q24654563 | ||
| Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions | Q27670746 | ||
| Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine | Q27672832 | ||
| Discovery of 1,2,4-Triazine Derivatives as Adenosine A 2A Antagonists using Structure Based Drug Design | Q27676559 | ||
| Recent developments in adenosine receptor ligands and their potential as novel drugs | Q27687253 | ||
| All-atom empirical potential for molecular modeling and dynamics studies of proteins | Q27860468 | ||
| VMD: visual molecular dynamics | Q27860554 | ||
| Scalable molecular dynamics with NAMD | Q27860718 | ||
| Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction | Q27860958 | ||
| Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations | Q29547631 | ||
| A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations | Q29547632 | ||
| Pocketome via comprehensive identification and classification of ligand binding envelopes. | Q30350345 | ||
| Pathway and mechanism of drug binding to G-protein-coupled receptors. | Q30503489 | ||
| Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias | Q33748133 | ||
| Ligand-specific conformation of extracellular loop-2 in the angiotensin II type 1 receptor | Q33855316 | ||
| Identification by site-directed mutagenesis of residues involved in ligand recognition and activation of the human A3 adenosine receptor | Q34118123 | ||
| The flexible pocketome engine for structural chemogenomics | Q34286648 | ||
| Extension of the CHARMM General Force Field to sulfonyl-containing compounds and its utility in biomolecular simulations. | Q34347574 | ||
| The extracellular loop 2 (ECL2) of the human histamine H4 receptor substantially contributes to ligand binding and constitutive activity | Q35550563 | ||
| The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice | Q35733326 | ||
| Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation | Q35763258 | ||
| Animal models for the study of adenosine receptor function. | Q35897185 | ||
| Stimulus bias provides evidence for conformational constraints in the structure of a G protein-coupled receptor | Q36347742 | ||
| Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor | Q36482631 | ||
| G protein coupled receptor structure and activation | Q36692097 | ||
| Molecular modeling of adenosine receptors: new results and trends. | Q36816987 | ||
| Separation of on-target efficacy from adverse effects through rational design of a bitopic adenosine receptor agonist | Q37674601 | ||
| Lifting the lid on GPCRs: the role of extracellular loops | Q37921853 | ||
| Ligand-Independent Adenosine A2B Receptor Constitutive Activity as a Promoter of Prostate Cancer Cell Proliferation | Q38801257 | ||
| The adenosine A1 receptor antagonist SLV320 reduces myocardial fibrosis in rats with 5/6 nephrectomy without affecting blood pressure | Q40122114 | ||
| Nucleoside modification and concerted mutagenesis of the human A3 adenosine receptor to probe interactions between the 2-position of adenosine analogs and Gln167 in the second extracellular loop. | Q40324884 | ||
| Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch | Q40712100 | ||
| Molecular recognition of peptide and non-peptide ligands by the extracellular domains of neurohypophysial hormone receptors | Q42158406 | ||
| Effect of a toggle switch mutation in TM6 of the human adenosine A₃ receptor on Gi protein-dependent signalling and Gi-independent receptor internalization | Q42176971 | ||
| Identification of the adenine binding site of the human A1 adenosine receptor | Q42536494 | ||
| A structure-activity analysis of biased agonism at the dopamine D2 receptor | Q44234043 | ||
| Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy | Q46387086 | ||
| Quantification of adenosine A(1) receptor biased agonism: Implications for drug discovery. | Q51740302 | ||
| The four cysteine residues in the second extracellular loop of the human adenosine A2B receptor: role in ligand binding and receptor function. | Q51767581 | ||
| The role of transmembrane domain 3 in the actions of orthosteric, allosteric, and atypical agonists of the M4 muscarinic acetylcholine receptor. | Q51769693 | ||
| Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors. | Q51797215 | ||
| Exploring the recognition pathway at the human A2A adenosine receptor of the endogenous agonist adenosine using supervised molecular dynamics simulations | Q56979477 | ||
| Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands | Q57838214 | ||
| P433 | issue | 6 | |
| P304 | page(s) | 703-714 | |
| P577 | publication date | 2016-09-28 | |
| P1433 | published in | Molecular Pharmacology | Q1943386 |
| P1476 | title | Extracellular Loop 2 of the Adenosine A1 Receptor Has a Key Role in Orthosteric Ligand Affinity and Agonist Efficacy | |
| P478 | volume | 90 |
| Q47935295 | A kinetic view of GPCR allostery and biased agonism |
| Q47441641 | A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines. |
| Q48732639 | Biochemical and Pharmacological Role of A1 Adenosine Receptors and Their Modulation as Novel Therapeutic Strategy |
| Q47242194 | Computer-aided design of multi-target ligands at A1R, A2AR and PDE10A, key proteins in neurodegenerative diseases |
| Q52586842 | Identification of avian vasotocin receptor subtype-specific antagonists involved in the stress response of the chicken, Gallus gallus. |
| Q47225761 | Impact of protein-ligand solvation and desolvation on transition state thermodynamic properties of adenosine A2A ligand binding kinetics |
| Q91710471 | Mechanistic Insights into Specific G Protein Interactions with Adenosine Receptors |
| Q52313686 | New Paradigms in Adenosine Receptor Pharmacology: Allostery, Oligomerization and Biased Agonism. |
| Q42291851 | Priming GPCR signaling through the synergistic effect of two G proteins. |
| Q64055813 | Probe dependence of allosteric enhancers on the binding affinity of adenosine A -receptor agonists at rat and human A -receptors measured using NanoBRET |
| Q59060936 | Structure of the adenosine-bound human adenosine A1 receptor–Gi complex |
| Q89723022 | Structure of the agonist 12-HHT in its BLT2 receptor-bound state |
| Q47417018 | Structure-Based Design of Potent and Selective Ligands at the Four Adenosine Receptors |
| Q47181411 | Synergistic Use of GPCR Modeling and SDM Experiments to Understand Ligand Binding. |
Search more.