Pathway and mechanism of drug binding to G-protein-coupled receptors.

scientific article

Pathway and mechanism of drug binding to G-protein-coupled receptors. is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PNAS..10813118D
P356DOI10.1073/PNAS.1104614108
P932PMC publication ID3156183
P698PubMed publication ID21778406
P5875ResearchGate publication ID51510897

P50authorDavid W. BorhaniQ42390809
Ron Ofer DrorQ59678272
Huafeng XuQ61146872
P2093author name stringDavid E Shaw
Yibing Shan
Albert C Pan
Daniel H Arlow
Paul Maragakis
P2860cites workHigh-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptorQ24657484
Structure of a beta1-adrenergic G-protein-coupled receptorQ27651011
Conserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray CrystallographyQ27663654
All-atom empirical potential for molecular modeling and dynamics studies of proteinsQ27860468
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor functionQ28254935
A ligand channel through the G protein coupled receptor opsinQ28474703
The structure and function of G-protein-coupled receptorsQ29616792
Mechanism of fast peptide recognition by SH3 domainsQ30157539
Electrostatic funneling of substrate in mitochondrial inner membrane carriersQ30482734
Structure-based discovery of beta2-adrenergic receptor ligandsQ33426241
A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptorQ33885350
Drug-target residence time: critical information for lead optimization.Q34054343
7 Isothermal Titration Calorimetry in Drug DiscoveryQ34483315
Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol bindingQ35076839
Ligand binding: molecular mechanics calculation of the streptavidin-biotin rupture forceQ36793608
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disordersQ37360436
NMR spectroscopy brings invisible protein states into focusQ37617946
Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytesQ39089506
Fundamental difference between the molecular interactions of agonists and antagonists with the β-adrenergic receptorQ39265422
How does a drug molecule find its target binding site?Q39280041
Binding of orthosteric ligands to the allosteric site of the M(2) muscarinic cholinergic receptorQ39972557
Ligand entry and exit pathways in the beta2-adrenergic receptorQ42933080
Negative cooperativity among beta-adrenergic receptors in frog erythrocyte membranesQ44182279
Measurement of the millisecond activation switch of G protein-coupled receptors in living cellsQ44479240
Site-directed mutagenesis of the rat beta1-adrenoceptor. Involvement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol bindingQ44966034
Observation of a dewetting transition in the collapse of the melittin tetramerQ46681654
Computer simulations of the diffusion of a substrate to an active site of an enzymeQ52594370
Time-resolved structural studies of protein reaction dynamics: a smorgasbord of X-ray approaches.Q55651990
Allosteric Modulation of G Protein–Coupled ReceptorsQ56115675
Modification of the binding properties of muscarinic receptors by gallamineQ71773661
Adrenergic ligand liposolubility in membranes. Direct assessment in a beta-adrenergic binding systemQ72952843
Ligand binding with stopped-flow rapid mixingQ81820158
Dewetting-controlled binding of ligands to hydrophobic pocketsQ84884849
P433issue32
P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
P304page(s)13118-13123
P577publication date2011-07-21
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titlePathway and mechanism of drug binding to G-protein-coupled receptors
P478volume108

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