| scholarly article | Q13442814 |
| P50 | author | Brian Kobilka | Q80907 |
| Raymond C. Stevens | Q7298638 | ||
| Vadim Cherezov | Q28320126 | ||
| William I Weis | Q42325569 | ||
| Søren G. F. Rasmussen | Q56896313 | ||
| Tong Sun Kobilka | Q69506919 | ||
| Michael A Hanson | Q91742960 | ||
| P2093 | author name string | Hee-Jung Choi | |
| Daniel M Rosenbaum | |||
| Foon Sun Thian | |||
| Søren G F Rasmussen | |||
| Xiao-Jie Yao | |||
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| P433 | issue | 5854 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | G protein-coupled receptor | Q38173 |
| P304 | page(s) | 1266-73 | |
| P577 | publication date | 2007-11-23 | |
| P1433 | published in | Science | Q192864 |
| P1476 | title | GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function | |
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| Q34029528 | Functionalized congeners of P2Y1 receptor antagonists: 2-alkynyl (N)-methanocarba 2'-deoxyadenosine 3',5'-bisphosphate analogues and conjugation to a polyamidoamine (PAMAM) dendrimer carrier |
| Q39963364 | Functions of acidic transmembrane residues in human melanocortin-3 receptor binding and activation |
| Q38672386 | Functions of intrinsic disorder in transmembrane proteins. |
| Q36033453 | Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptors |
| Q35841518 | Fusion-protein-assisted protein crystallization |
| Q35065927 | G protein-coupled receptors--recent advances |
| Q41692321 | G protein-coupled receptors: computer-aided ligand discovery and computational structural analyses in the 2010s |
| Q104795034 | G protein-coupled receptors: structure- and function-based drug discovery |
| Q39419666 | G-Protein coupled receptors: answers from simulations |
| Q38848557 | G-protein coupled receptors: advances in simulation and drug discovery |
| Q37800371 | G-protein-coupled receptor structure: what can we learn? |
| Q30378190 | G-protein-coupled receptor structures were not built in a day |
| Q35008612 | GCR2 is a new member of the eukaryotic lanthionine synthetase component C-like protein family |
| Q30437388 | GPCR 3D homology models for ligand screening: lessons learned from blind predictions of adenosine A2a receptor complex |
| Q55564362 | GPCR Conformations: Implications for Rational Drug Design. |
| Q38810192 | GPCR agonist binding revealed by modeling and crystallography |
| Q33642442 | GPCR and G proteins: drug efficacy and activation in live cells. |
| Q58568628 | GPCR drug discovery: integrating solution NMR data with crystal and cryo-EM structures |
| Q27323329 | GPCR-ModSim: A comprehensive web based solution for modeling G-protein coupled receptors |
| Q34413389 | GPCRRD: G protein-coupled receptor spatial restraint database for 3D structure modeling and function annotation |
| Q59042560 | GPCRs: Lipid-Dependent Membrane Receptors That Act as Drug Targets |
| Q90312422 | Generating Recombinant Antibodies to Membrane Proteins through Phage Display |
| Q41692346 | Graph analysis of β2 adrenergic receptor structures: a "social network" of GPCR residues |
| Q36359772 | Harvesting and cryo-cooling crystals of membrane proteins grown in lipidic mesophases for structure determination by macromolecular crystallography |
| Q41226865 | High constitutive activity is an intrinsic feature of ghrelin receptor protein: a study with a functional monomeric GHS-R1a receptor reconstituted in lipid discs |
| Q37909724 | High throughput platforms for structural genomics of integral membrane proteins |
| Q24657484 | High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor |
| Q27675402 | High-resolution crystal structure of human protease-activated receptor 1 |
| Q33694212 | High-resolution crystal structure of the human CB1 cannabinoid receptor |
| Q36677146 | High-resolution distance mapping in rhodopsin reveals the pattern of helix movement due to activation |
| Q24301044 | High-resolution structure of the human GPR40 receptor bound to allosteric agonist TAK-875 |
| Q37001789 | Highly Branched Pentasaccharide-Bearing Amphiphiles for Membrane Protein Studies |
| Q34359302 | Highly conserved tyrosine stabilizes the active state of rhodopsin |
| Q38812016 | Hitchhiking on the heptahelical highway: structure and function of 7TM receptor complexes. |
| Q42212856 | Hologram quantitative structure activity relationship, docking, and molecular dynamics studies of inhibitors for CXCR4. |
| Q35181896 | Homology Model Versus X-ray Structure in Receptor-based Drug Design: A Retrospective Analysis with the Dopamine D3 Receptor |
| Q44530514 | Homology model and docking studies on porcine β₂ adrenoceptor: description of two binding sites. |
| Q51784685 | Homology modeling and flex-ligand docking studies on the guinea pig beta(2) adrenoceptor: structural and experimental similarities/ differences with the human beta(2). |
| Q42806068 | Homology modeling of a Class A GPCR in the inactive conformation: A quantitative analysis of the correlation between model/template sequence identity and model accuracy |
| Q35967081 | Homology modeling of class a G protein-coupled receptors |
| Q43276048 | Homology modelling of the human adenosine A2B receptor based on X-ray structures of bovine rhodopsin, the beta2-adrenergic receptor and the human adenosine A2A receptor |
| Q36421791 | How Can Mutations Thermostabilize G-Protein-Coupled Receptors? |
| Q47194737 | Human Adenosine A2A Receptor: Molecular Mechanism of Ligand Binding and Activation. |
| Q37305302 | Human Serotonin 5-HT2C G Protein-Coupled Receptor Homology Model from the β2 Adrenoceptor Structure: Ligand Docking and Mutagenesis Studies |
| Q61798028 | Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography |
| Q33996731 | Hydrophobic residues in helix 8 of cannabinoid receptor 1 are critical for structural and functional properties |
| Q37979710 | Ice breaking in GPCR structural biology |
| Q35554301 | Identification of destabilizing and stabilizing mutations of Ste2p, a G protein-coupled receptor in Saccharomyces cerevisiae |
| Q37438039 | Identification of specific transmembrane residues and ligand-induced interface changes involved in homo-dimer formation of a yeast G protein-coupled receptor |
| Q33887246 | Identification of the GPR55 agonist binding site using a novel set of high-potency GPR55 selective ligands |
| Q35387937 | Identification of the differentially expressed genes associated with familial combined hyperlipidemia using bioinformatics analysis |
| Q24645752 | Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations |
| Q33400428 | Identifying conformational changes of the beta(2) adrenoceptor that enable accurate prediction of ligand/receptor interactions and screening for GPCR modulators |
| Q38023797 | Impact of helix irregularities on sequence alignment and homology modeling of G protein-coupled receptors |
| Q49507908 | Improved in Vitro Folding of the Y2 G Protein-Coupled Receptor into Bicelles. |
| Q27316812 | In meso in situ serial X-ray crystallography of soluble and membrane proteins at cryogenic temperatures |
| Q35057759 | In silico analysis of the binding of agonists and blockers to the β2-adrenergic receptor. |
| Q42979856 | In silico analysis of the histaprodifen induced activation pathway of the guinea-pig histamine H(1)-receptor |
| Q42730804 | In silico identification of new ligands for GPR17: a promising therapeutic target for neurodegenerative diseases |
| Q35693310 | In silico screening for agonists and blockers of the β(2) adrenergic receptor: implications of inactive and activated state structures |
| Q47213731 | Increasing the Stability of Recombinant Human Green Cone Pigment. |
| Q33767121 | Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery? |
| Q93143025 | Influence of the Structural Accuracy of Homology Models on Their Applicability to Docking-Based Virtual Screening: The β2 Adrenergic Receptor as a Case Study |
| Q56648606 | Insights into signaling from the β2-adrenergic receptor structure |
| Q44346651 | Insights into subtype selectivity of opioid agonists by ligand-based and structure-based methods |
| Q87345890 | Insights into the influence of 5-HT2c aminoacidic variants with the inhibitory action of serotonin inverse agonists and antagonists |
| Q53189799 | Insilico study of the A(2A)R-D (2)R kinetics and interfacial contact surface for heteromerization. |
| Q37520862 | Interaction and conformational dynamics of membrane-spanning protein helices |
| Q48812098 | Interactions of recombinant human histamine H₁R, H₂R, H₃R, and H₄R receptors with 34 antidepressants and antipsychotics. |
| Q47953339 | Interleukin-1β causes anxiety by interacting with the endocannabinoid system. |
| Q37782458 | Internally bridging water molecule in transmembrane α-helical kink |
| Q24623433 | International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors |
| Q90484890 | Interplay between the electrostatic membrane potential and conformational changes in membrane proteins |
| Q35977592 | Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi. |
| Q39264759 | Involvement of the first transmembrane segment of human α(2) -adrenoceptors in the subtype-selective binding of chlorpromazine, spiperone and spiroxatrine. |
| Q38706167 | Isolation and structure-function characterization of a signaling-active rhodopsin-G protein complex |
| Q47163479 | Isomeric Detergent Comparison for Membrane Protein Stability: Importance of Inter-Alkyl-Chain Distance and Alkyl Chain Length. |
| Q41961309 | LCP-FRAP Assay for Pre-Screening Membrane Proteins for in Meso Crystallization |
| Q33795500 | LCP-Tm: an assay to measure and understand stability of membrane proteins in a membrane environment |
| Q26866010 | Large-scale production and protein engineering of G protein-coupled receptors for structural studies |
| Q24623930 | Lessons from the lysozyme of phage T4 |
| Q41829504 | Ligand Binding Ensembles Determine Graded Agonist Efficacies at a G Protein-coupled Receptor |
| Q34412157 | Ligand Binding Sensitivity of the Extracellular Loop Two of the Cannabinoid Receptor 1. |
| Q37464148 | Ligand and structure-based methodologies for the prediction of the activity of G protein-coupled receptor ligands |
| Q33636089 | Ligand and structure-based models for the prediction of ligand-receptor affinities and virtual screenings: Development and application to the beta(2)-adrenergic receptor |
| Q42933080 | Ligand entry and exit pathways in the beta2-adrenergic receptor |
| Q42380834 | Ligand modulation of sidechain dynamics in a wild-type human GPCR. |
| Q33650270 | Ligand-based peptide design and combinatorial peptide libraries to target G protein-coupled receptors |
| Q41823093 | Ligand-regulated oligomerization of beta(2)-adrenoceptors in a model lipid bilayer |
| Q35863890 | Ligand-specific interactions modulate kinetic, energetic, and mechanical properties of the human β2 adrenergic receptor |
| Q27646733 | Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor |
| Q30153243 | Lipid bilayer-bound conformation of an integral membrane beta barrel protein by multidimensional MAS NMR. |
| Q35008243 | Lipid cubic phase as a membrane mimetic for integral membrane protein enzymes |
| Q42660693 | Lipid protein interactions couple protonation to conformation in a conserved cytosolic domain of G protein-coupled receptors |
| Q47223560 | Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination. |
| Q36930850 | Lysophospholipid interactions with protein targets |
| Q34712509 | Maltose-neopentyl glycol (MNG) amphiphiles for solubilization, stabilization and crystallization of membrane proteins |
| Q34054370 | Mapping the druggable allosteric space of G-protein coupled receptors: a fragment-based molecular dynamics approach |
| Q35192004 | Mechanism for adhesion G protein-coupled receptor GPR56-mediated RhoA activation induced by collagen III stimulation. |
| Q45938036 | Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. |
| Q36737228 | Mechanism of signal propagation upon retinal isomerization: insights from molecular dynamics simulations of rhodopsin restrained by normal modes |
| Q41645695 | Mechanisms involved in VPAC receptors activation and regulation: lessons from pharmacological and mutagenesis studies |
| Q27681476 | Mechanistic Strategies for Catalysis Adopted by Evolutionary Distinct Family 43 Arabinanases |
| Q42072255 | MemProtMD: Automated Insertion of Membrane Protein Structures into Explicit Lipid Membranes. |
| Q36654207 | Membrane cholesterol affects stimulus-activity coupling in type 1, but not type 2, CCK receptors: use of cell lines with elevated cholesterol. |
| Q30155276 | Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes |
| Q33880152 | Mesitylene-Cored Glucoside Amphiphiles (MGAs) for Membrane Protein Studies: Importance of Alkyl Chain Density in Detergent Efficacy. |
| Q40274047 | Metal ions-binding T4 lysozyme as an intramolecular protein purification tag compatible with X-ray crystallography |
| Q26991511 | Metaphors, naming and new signaling paradigms by G-protein-coupled receptors |
| Q38318691 | Methodological advances: the unsung heroes of the GPCR structural revolution. |
| Q30412884 | Methods of protein structure comparison |
| Q37691765 | Microbial and animal rhodopsins: structures, functions, and molecular mechanisms. |
| Q34498063 | Modeling G Protein-Coupled Receptors: a Concrete Possibility |
| Q34167891 | Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR. |
| Q89810534 | Modeling the allosteric modulation on a G-Protein Coupled Receptor: the case of M2 muscarinic Acetylcholine Receptor in complex with LY211960 |
| Q33937574 | Modern homology modeling of G-protein coupled receptors: which structural template to use? |
| Q27650678 | Modest stabilization by most hydrogen-bonded side-chain interactions in membrane proteins |
| Q35533294 | Modified T4 Lysozyme Fusion Proteins Facilitate G Protein-Coupled Receptor Crystallogenesis |
| Q37060802 | Molecular Determinants for Ligand Binding at Serotonin 5-HT2A and 5-HT2C GPCRs: Experimental Affinity Results Analyzed by Molecular Modeling and Ligand Docking Studies |
| Q51603697 | Molecular Modelling of G Protein-Coupled Receptors Through the Web. |
| Q36002904 | Molecular basis for binding and subtype selectivity of 1,4-benzodiazepine antagonist ligands of the cholecystokinin receptor |
| Q33858991 | Molecular determinants of ligand binding at the human histamine H1 receptor: Site-directed mutagenesis results analyzed with ligand docking and molecular dynamics studies at H1 homology and crystal structure models |
| Q52309570 | Molecular dynamics simulation of d-Benzedrine transmitting through molecular channels within D3R. |
| Q42754544 | Molecular dynamics simulations on the Tre1 G protein-coupled receptor: exploring the role of the arginine of the NRY motif in Tre1 structure |
| Q28542663 | Molecular insights into the dynamics of pharmacogenetically important N-terminal variants of the human β2-adrenergic receptor |
| Q36773326 | Molecular mechanism of β-arrestin-biased agonism at seven-transmembrane receptors |
| Q37234988 | Molecular mechanisms of mechanosensing and their roles in fungal contact sensing |
| Q42582195 | Molecular modeling of the M3 acetylcholine muscarinic receptor and its binding site |
| Q46409320 | Molecular modeling studies give hint for the existence of a symmetric hβ₂R-Gαβγ-homodimer |
| Q91595350 | Molecular pharmacology of metabotropic receptors targeted by neuropsychiatric drugs |
| Q37111743 | Molecular properties of muscarinic acetylcholine receptors |
| Q34327700 | Molecular signatures of G-protein-coupled receptors |
| Q30406132 | Molecular simulations and solid-state NMR investigate dynamical structure in rhodopsin activation |
| Q43195607 | Monitoring protein conformational changes and dynamics using stable-isotope labeling and mass spectrometry |
| Q46605612 | Multi-receptor binding profile of clozapine and olanzapine: a structural study based on the new beta2 adrenergic receptor template |
| Q36115098 | Multiple ligand-specific conformations of the β2-adrenergic receptor |
| Q40024079 | Multiple roles for the C-terminal tail of the chemokine scavenger D6. |
| Q38218059 | Muscarinic acetylcholine receptors: novel opportunities for drug development |
| Q39906654 | N(G)-acylated aminothiazolylpropylguanidines as potent and selective histamine H(2) receptor agonists |
| Q27674422 | N-Terminal T4 Lysozyme Fusion Facilitates Crystallization of a G Protein Coupled Receptor |
| Q47194753 | Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1. |
| Q30382600 | Nanobodies as Probes for Protein Dynamics in Vitro and in Cells. |
| Q33880125 | Nanobodies to Study G Protein-Coupled Receptor Structure and Function |
| Q27690729 | Nanobody stabilization of G protein-coupled receptor conformational states. |
| Q38060667 | Neuropeptides and neuropeptide receptors: drug targets, and peptide and non-peptide ligands: a tribute to Prof. Dieter Seebach |
| Q37323435 | Neurotransmitter receptor heteromers in neurodegenerative diseases and neural plasticity. |
| Q96161939 | New Malonate-Derived Tetraglucoside Detergents for Membrane Protein Stability |
| Q38933295 | New Trends in Inspecting GPCR-ligand Recognition Process: the Contribution of the Molecular Modeling Section (MMS) at the University of Padova |
| Q39332114 | New approaches towards the understanding of integral membrane proteins: A structural perspective on G protein-coupled receptors |
| Q26991761 | New insights for drug design from the X-ray crystallographic structures of G-protein-coupled receptors |
| Q38815332 | New paradigms in chemokine receptor signal transduction: Moving beyond the two-site model. |
| Q47797929 | New penta-saccharide-bearing tripod amphiphiles for membrane protein structure studies |
| Q48287996 | Nobel Prize for Chemistry 2012: GPCRs seen through a crystal ball. |
| Q30374996 | Novel Xylene-Linked Maltoside Amphiphiles (XMAs) for Membrane Protein Stabilisation |
| Q38259766 | Novel approaches for targeting the adenosine A2A receptor |
| Q37495839 | Novel carvedilol analogues that suppress store-overload-induced Ca2+ release |
| Q51522567 | Novel computational methodologies for structural modeling of spacious ligand binding sites of G-protein-coupled receptors: development and application to human leukotriene B4 receptor. |
| Q37626522 | Novel tripod amphiphiles for membrane protein analysis |
| Q56592630 | Odorant Receptor 7D4 Activation Dynamics |
| Q36744266 | On the applicability of GPCR homology models to computer-aided drug discovery: a comparison between in silico and crystal structures of the beta2-adrenergic receptor. |
| Q56877460 | One hundred years of X-ray diffraction, 50 years of structural biology |
| Q44333492 | Opioid receptors revealed |
| Q37249017 | Opioid receptors: from binding sites to visible molecules in vivo |
| Q26866088 | Opportunities and challenges for time-resolved studies of protein structural dynamics at X-ray free-electron lasers |
| Q34670650 | Opsin is a phospholipid flippase |
| Q30401692 | Overcoming barriers to membrane protein structure determination |
| Q34803434 | Overcoming the challenges of membrane protein crystallography. |
| Q39470722 | Overexpressing human membrane proteins in stably transfected and clonal human embryonic kidney 293S cells |
| Q24317396 | PROKR2 missense mutations associated with Kallmann syndrome impair receptor signalling activity |
| Q30503489 | Pathway and mechanism of drug binding to G-protein-coupled receptors. |
| Q96302430 | Pendant-bearing glucose-neopentyl glycol (P-GNG) amphiphiles for membrane protein manipulation: Importance of detergent pendant chain for protein stabilization |
| Q41774653 | Perspective: Markov models for long-timescale biomolecular dynamics |
| Q36316813 | Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound β1-Adrenergic Receptor. |
| Q38944804 | Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutants in the Sf9 Cell Expression System. |
| Q39704718 | Pharmacological characterization of 30 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists, synthetic agonists, and the endogenous agouti-related protein antagonist |
| Q39640436 | Phe369(7.38) at human 5-HT(7) receptors confers interspecies selectivity to antagonists and partial agonists. |
| Q42425022 | PheVI:09 (Phe6.44) as a sliding microswitch in seven-transmembrane (7TM) G protein-coupled receptor activation |
| Q37366101 | Phospholipids are needed for the proper formation, stability, and function of the photoactivated rhodopsin-transducin complex |
| Q48240503 | Phosphorylation-induced conformation of β2-adrenoceptor related to arrestin recruitment revealed by NMR. |
| Q38016154 | Physiology and emerging biochemistry of the glucagon-like peptide-1 receptor |
| Q41243070 | Platform for the rapid construction and evaluation of GPCRs for crystallography in Saccharomyces cerevisiae |
| Q38028542 | Platforms for the identification of GPCR targets, and of orthosteric and allosteric modulators. |
| Q42741366 | Polymer-based cell-free expression of ligand-binding family B G-protein coupled receptors without detergents |
| Q26849743 | Post-expression strategies for structural investigations of membrane proteins |
| Q38946091 | Predicting phenotype from genotype: Improving accuracy through more robust experimental and computational modeling |
| Q92594361 | Prediction of Conformation Specific Thermostabilizing Mutations for Class A G Protein-Coupled Receptors |
| Q36077712 | Preparation of an activated rhodopsin/transducin complex using a constitutively active mutant of rhodopsin |
| Q37020421 | Probes for narcotic receptor mediated phenomena. 37. Synthesis and opioid binding affinity of the final pair of oxide-bridged phenylmorphans, the ortho- and para-b-isomers and their N-phenethyl analogues, and the synthesis of the N-phenethyl analogu |
| Q46718105 | Probing distal regions of the A2B adenosine receptor by quantitative structure-activity relationship modeling of known and novel agonists. |
| Q37274469 | Probing the role of the cation-pi interaction in the binding sites of GPCRs using unnatural amino acids. |
| Q38671723 | Production of Chemokine/Chemokine Receptor Complexes for Structural Biophysical Studies. |
| Q50512769 | Production of the stable human histamine H₁ receptor in Pichia pastoris for structural determination. |
| Q36747747 | Profile of Brian K. Kobilka and Robert J. Lefkowitz, 2012 Nobel laureates in chemistry |
| Q34358923 | Profiling the interaction mechanism of quinoline/quinazoline derivatives as MCHR1 antagonists: an in silico method |
| Q35095066 | Progress in elucidating the structural and dynamic character of G Protein-Coupled Receptor oligomers for use in drug discovery |
| Q56979272 | Progress in the structural prediction of G protein-coupled receptors: D3 receptor in complex with eticlopride |
| Q37362453 | Promiscuous drugs as therapeutics for chemokine receptors |
| Q89843914 | Protein Footprinting: Auxiliary Engine to Power the Structural Biology Revolution |
| Q27687870 | Protein design by fusion: implications for protein structure prediction and evolution |
| Q42071118 | Protein microcrystallography using synchrotron radiation |
| Q47857119 | Protein structures: Structures of desire |
| Q37446783 | Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2. |
| Q44607630 | Putative cholesterol-binding sites in human immunodeficiency virus (HIV) coreceptors CXCR4 and CCR5. |
| Q90156829 | RCSB Protein Data Bank: Enabling biomedical research and drug discovery |
| Q53188593 | Radioligand binding analysis as a tool for quality control of GPCR production for structural characterization: adenosine A(2a)R as a template for study. |
| Q34503044 | Rapid Computational Prediction of Thermostabilizing Mutations for G Protein-Coupled Receptors. |
| Q94445335 | Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies |
| Q33747204 | Rastering strategy for screening and centring of microcrystal samples of human membrane proteins with a sub-10 microm size X-ray synchrotron beam. |
| Q37334040 | Ratiocinative screen of eukaryotic integral membrane protein expression and solubilization for structure determination |
| Q61904303 | Rationally Engineered Tandem Facial Amphiphiles for Improved Membrane Protein Stabilization Efficacy |
| Q35048773 | Reassessment of the unique mode of binding between angiotensin II type 1 receptor and their blockers |
| Q37416441 | Recent advances in structure-based virtual screening of G-protein coupled receptors |
| Q34278937 | Recent progress in the structure determination of GPCRs, a membrane protein family with high potential as pharmaceutical targets |
| Q36785514 | Regulation of α2B-Adrenerigc Receptor Export Trafficking by Specific Motifs |
| Q37589121 | Retinal dynamics during light activation of rhodopsin revealed by solid-state NMR spectroscopy |
| Q26747130 | Revealing Atomic-Level Mechanisms of Protein Allostery with Molecular Dynamics Simulations |
| Q42269169 | Reversed binding of a small molecule ligand in homologous chemokine receptors - differential role of extracellular loop 2. |
| Q28266829 | Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors |
| Q33569254 | Rhodopsin and the others: a historical perspective on structural studies of G protein-coupled receptors |
| Q38862301 | Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding |
| Q39498635 | Role of the second and third extracellular loops of the histamine H(4) receptor in receptor activation |
| Q90700670 | Rules of Engagement: GPCRs and G Proteins |
| Q35091511 | S-nitrosylation-regulated GPCR signaling |
| Q58568349 | Science Librarians Analysis of the 2012 Nobel Prize in Chemistry: The Work of Robert Lefkowitz and Brian Kobilka |
| Q37137758 | Selecting optimum eukaryotic integral membrane proteins for structure determination by rapid expression and solubilization screening |
| Q34962263 | Selective 5-hydroxytryptamine 2C receptor agonists derived from the lead compound tranylcypromine: identification of drugs with antidepressant-like action |
| Q36186107 | Selectivity in the Use of Gi/o Proteins Is Determined by the DRF Motif in CXCR6 and Is Cell-Type Specific |
| Q93056270 | Self-Assembly Behavior and Application of Terphenyl-Cored Trimaltosides for Membrane-Protein Studies: Impact of Detergent Hydrophobic Group Geometry on Protein Stability |
| Q92999325 | Self-Assembly Behaviors of a Penta-Phenylene Maltoside and Its Application for Membrane Protein Study |
| Q28649590 | Sequence, structure and ligand binding evolution of rhodopsin-like G protein-coupled receptors: a crystal structure-based phylogenetic analysis |
| Q33890786 | Seven transmembrane receptors as shapeshifting proteins: the impact of allosteric modulation and functional selectivity on new drug discovery |
| Q38775792 | Similarity- and Substructure-Based Development of β2-Adrenergic Receptor Ligands Based on Unusual Scaffolds |
| Q44559624 | Simulations of a G protein-coupled receptor homology model predict dynamic features and a ligand binding site |
| Q34782818 | Single-molecule force spectroscopy of G-protein-coupled receptors. |
| Q40054046 | Site-specific incorporation of keto amino acids into functional G protein-coupled receptors using unnatural amino acid mutagenesis. |
| Q28480422 | Small molecules with similar structures exhibit agonist, neutral antagonist or inverse agonist activity toward angiotensin II type 1 receptor |
| Q33633178 | Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance |
| Q38448843 | Sphingosine-1-phosphate metabolism: A structural perspective |
| Q47849019 | Spirohexene-Tetrazine Ligation Enables Bioorthogonal Labeling of Class B G Protein-Coupled Receptors in Live Cells |
| Q27680775 | Split green fluorescent protein as a modular binding partner for protein crystallization |
| Q35486811 | Stabilization of G protein-coupled receptors by point mutations |
| Q40020328 | Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structure |
| Q44608235 | Stealth carriers for low-resolution structure determination of membrane proteins in solution |
| Q52585354 | Steroid-based amphiphiles for membrane protein study: Importance of alkyl spacer for protein stability. |
| Q27676750 | Steroid-based facial amphiphiles for stabilization and crystallization of membrane proteins |
| Q37776038 | Strategies for the cloning and expression of membrane proteins |
| Q27680463 | Structural Analysis and Optimization of the Covalent Association between SpyCatcher and a Peptide Tag |
| Q51337340 | Structural Analysis of the Histamine H1 Receptor. |
| Q51539813 | Structural Basis and Mechanism of Chiral Benzedrine Molecules Interacting With Third Dopamine Receptor. |
| Q92817538 | Structural Basis for Allosteric Ligand Recognition in the Human CC Chemokine Receptor 7 |
| Q42694413 | Structural Basis for G Protein-Coupled Receptor Activation |
| Q27652199 | Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12 |
| Q39084919 | Structural Insights into Sigma1 Function |
| Q35638953 | Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling |
| Q38831305 | Structural Reconstruction of Protein-Protein Complexes Involved in Intracellular Signaling |
| Q26783016 | Structural Studies of G Protein-Coupled Receptors |
| Q27678733 | Structural Studies of Wnts and Identification of an LRP6 Binding Site |
| Q90659183 | Structural Variability in the RLR-MAVS Pathway and Sensitive Detection of Viral RNAs |
| Q93006962 | Structural Variability of EspG Chaperones from Mycobacterial ESX-1, ESX-3, and ESX-5 Type VII Secretion Systems |
| Q37232161 | Structural analysis of the human cannabinoid receptor one carboxyl-terminus identifies two amphipathic helices. |
| Q36188948 | Structural and Functional Effect of an Oscillating Electric Field on the Dopamine-D3 Receptor: A Molecular Dynamics Simulation Study |
| Q30152958 | Structural and biophysical characterization of an epitope-specific engineered Fab fragment and complexation with membrane proteins: implications for co-crystallization |
| Q33913886 | Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations |
| Q100755370 | Structural and functional characterization of G protein-coupled receptors with deep mutational scanning |
| Q28237034 | Structural approaches to understanding retinal proteins needed for vision |
| Q35790289 | Structural aspects of M₃ muscarinic acetylcholine receptor dimer formation and activation |
| Q34073218 | Structural basis for μ-opioid receptor binding and activation |
| Q97650820 | Structural basis of GPBAR activation and bile acid recognition |
| Q38734550 | Structural basis of activation of bitter taste receptor T2R1 and comparison with Class A G-protein-coupled receptors (GPCRs) |
| Q90665799 | Structural basis of chemokine and receptor interactions: Key regulators of leukocyte recruitment in inflammatory responses |
| Q52316530 | Structural basis of ligand binding modes at the neuropeptide Y Y1 receptor. |
| Q37454403 | Structural basis of the interaction between chemokine stromal cell-derived factor-1/CXCL12 and its G-protein-coupled receptor CXCR4. |
| Q37441082 | Structural basis of the selectivity of the beta(2)-adrenergic receptor for fluorinated catecholamines. |
| Q51761770 | Structural biology of G protein-coupled receptors: new opportunities from XFELs and cryoEM. |
| Q38204271 | Structural biology of the S1P1 receptor |
| Q43145800 | Structural biology: A moving story of receptors |
| Q43235004 | Structural biology: How opioid drugs bind to receptors |
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| Q57151843 | Structural diversity and flexibility of diabodies |
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| Q41866579 | Structural insights into conformational stability of wild-type and mutant beta1-adrenergic receptor. |
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| Q30380117 | Structural waters define a functional channel mediating activation of the GPCR, rhodopsin. |
| Q57015852 | Structure and Modeling of GPCRs: Implications for Drug Discovery |
| Q37479887 | Structure and dynamics of a constitutively active neurotensin receptor |
| Q27677433 | Structure and dynamics of the M3 muscarinic acetylcholine receptor |
| Q24620291 | Structure and function of an irreversible agonist-β(2) adrenoceptor complex |
| Q27704228 | Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors |
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| Q42285749 | Structure determination of membrane proteins in their native phospholipid bilayer environment by rotationally aligned solid-state NMR spectroscopy |
| Q96302945 | Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane |
| Q27651011 | Structure of a beta1-adrenergic G-protein-coupled receptor |
| Q60300327 | Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy |
| Q24597139 | Structure of a nanobody-stabilized active state of the β(2) adrenoceptor |
| Q24296388 | Structure of an agonist-bound human A2A adenosine receptor |
| Q90975764 | Structure of an allosteric modulator bound to the CB1 cannabinoid receptor |
| Q27672832 | Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine |
| Q52315658 | Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone. |
| Q27666030 | Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist |
| Q59060936 | Structure of the adenosine-bound human adenosine A1 receptor–Gi complex |
| Q27674395 | Structure of the agonist-bound neurotensin receptor |
| Q27674645 | Structure of the chemokine receptor CXCR1 in phospholipid bilayers |
| Q24628686 | Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist |
| Q100750121 | Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode |
| Q24595968 | Structure of the human histamine H1 receptor complex with doxepin |
| Q24308048 | Structure of the human κ-opioid receptor in complex with JDTic |
| Q36497002 | Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors |
| Q33560239 | Structure-based discovery of A2A adenosine receptor ligands |
| Q33426241 | Structure-based discovery of beta2-adrenergic receptor ligands |
| Q30435017 | Structure-based discovery of novel chemotypes for adenosine A(2A) receptor antagonists |
| Q34983219 | Structure-based ligand discovery targeting orthosteric and allosteric pockets of dopamine receptors |
| Q30576993 | Structure-function of the G protein-coupled receptor superfamily |
| Q39121630 | Study of two G-protein coupled receptor variants of human trace amine-associated receptor 5. |
| Q33615741 | Subtype selectivity of dopamine receptor ligands: insights from structure and ligand-based methods |
| Q93054793 | Surface Plasmon Resonance as a Tool for Ligand Binding Investigation of Engineered GPR17 Receptor, a G Protein Coupled Receptor Involved in Myelination |
| Q30887281 | Surface plasmon resonance for high-throughput ligand screening of membrane-bound proteins |
| Q36431626 | Synthesis and structure-affinity relationships of selective high-affinity 5-HT(4) receptor antagonists: application to the design of new potential single photon emission computed tomography tracers |
| Q27665931 | Synthetic symmetrization in the crystallization and structure determination of CelA fromThermotoga maritima |
| Q88994083 | T4 lysozyme-facilitated crystallization of the human molybdenum cofactor-dependent enzyme mARC |
| Q42244148 | T4-lysozyme fusion for the production of human formyl peptide receptors for structural determination |
| Q33738010 | Tandem facial amphiphiles for membrane protein stabilization |
| Q33822322 | Tandem malonate-based glucosides (TMGs) for membrane protein structural studies |
| Q42331678 | Tandem neopentyl glycol maltosides (TNMs) for membrane protein stabilisation |
| Q90529594 | Targeting of G-protein coupled receptors in sepsis |
| Q30252224 | The "Sticky Patch" Model of Crystallization and Modification of Proteins for Enhanced Crystallizability |
| Q27682443 | The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor |
| Q24654563 | The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist |
| Q37957791 | The A3 adenosine receptor as multifaceted therapeutic target: pharmacology, medicinal chemistry, and in silico approaches |
| Q27680068 | The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation |
| Q35685881 | The Effects of the Recombinant CCR5 T4 Lysozyme Fusion Protein on HIV-1 Infection |
| Q38682286 | The Energetics of Chromophore Binding in the Visual Photoreceptor Rhodopsin. |
| Q84603072 | The Family of G Protein-Coupled Receptors: An Example of Membrane Proteins |
| Q37045212 | The GPCR Network: a large-scale collaboration to determine human GPCR structure and function |
| Q27677349 | The Glove-like Structure of the Conserved Membrane Protein TatC Provides Insight into Signal Sequence Recognition in Twin-Arginine Translocation |
| Q47780061 | The Human Orexin/Hypocretin Receptor Crystal Structures |
| Q64987318 | The Molecular Basis of G Protein-Coupled Receptor Activation. |
| Q30415339 | The Protein Structure Initiative: achievements and visions for the future |
| Q42042812 | The Recognition of Identical Ligands by Unrelated Proteins |
| Q27678608 | The Structure of the Mercury Transporter MerF in Phospholipid Bilayers: A Large Conformational Rearrangement Results from N-Terminal Truncation |
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| Q46137779 | The azulene framework as a novel arene bioisostere: design of potent dopamine D4 receptor ligands inducing penile erection |
| Q34363831 | The chemical basis of pharmacology |
| Q35216471 | The design, synthesis and pharmacological characterization of novel β₂-adrenoceptor antagonists. |
| Q97568780 | The discovery of a new antibody for BRIL-fused GPCR structure determination |
| Q36651876 | The dynamic process of β(2)-adrenergic receptor activation |
| Q37200963 | The effect of ligand efficacy on the formation and stability of a GPCR-G protein complex |
| Q36000382 | The evolving impact of g protein-coupled receptor kinases in cardiac health and disease |
| Q42948753 | The fifth transmembrane domain of angiotensin II Type 1 receptor participates in the formation of the ligand-binding pocket and undergoes a counterclockwise rotation upon receptor activation |
| Q27701469 | The high-resolution crystal structure of phosphatidylinositol 4-kinase IIβ and the crystal structure of phosphatidylinositol 4-kinase IIα containing a nucleoside analogue provide a structural basis for isoform-specific inhibitor design |
| Q24628661 | The impact of GPCR structures on pharmacology and structure-based drug design |
| Q30277230 | The impact of structural genomics: the first quindecennial |
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| Q102075582 | The importance of the membrane for biophysical measurements |
| Q41823226 | The importance of valine 114 in ligand binding in beta(2)-adrenergic receptor |
| Q48251393 | The macro domain as fusion tag for carrier-driven crystallization |
| Q37344009 | The magnitude of the light-induced conformational change in different rhodopsins correlates with their ability to activate G proteins |
| Q36003378 | The melanocortin-4 receptor: physiology, pharmacology, and pathophysiology. |
| Q41906066 | The micelle-associated 3D structures of Boc-Y(SO3)-Nle-G-W-Nle-D-2-phenylethylester (JMV-180) and CCK-8(s) share conformational elements of a calculated CCK1 receptor-bound model. |
| Q37179691 | The molecular basis of species-specific ligand activation of trace amine-associated receptor 1 (TAAR(1)). |
| Q38204270 | The organization of the sphingosine 1-phosphate signaling system |
| Q37381287 | The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor |
| Q30377191 | The role of experimental and computational structural approaches in 7TM drug discovery. |
| Q38188734 | The role of protein dynamics in GPCR function: insights from the β2AR and rhodopsin |
| Q30416991 | The role of protein structural analysis in the next generation sequencing era. |
| Q48982673 | The roles of computational chemistry in the ligand design of G protein-coupled receptors: how far have we come and what should we expect? |
| Q48287610 | The seven pillars of molecular pharmacology: GPCR research honored with Nobel Prize for chemistry. |
| Q35264433 | The significance of G protein-coupled receptor crystallography for drug discovery |
| Q33651185 | The structural basis of G-protein-coupled receptor signaling (Nobel Lecture) |
| Q29616792 | The structure and function of G-protein-coupled receptors |
| Q38062457 | The very large G protein coupled receptor (Vlgr1) in hair cells |
| Q37078649 | The α-Arrestin ARRDC3 Regulates the Endosomal Residence Time and Intracellular Signaling of the β2-Adrenergic Receptor |
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| Q35546383 | Thermodynamics of peptide and non-peptide interactions with the human 5HT1a receptor |
| Q36917238 | Thermostabilisation of the serotonin transporter in a cocaine-bound conformation |
| Q37032791 | Thermostabilization of the β1-adrenergic receptor correlates with increased entropy of the inactive state |
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| Q37937552 | Third-generation long-acting β₂-adrenoceptor agonists: medicinal chemistry strategies employed in the identification of once-daily inhaled β₂-adrenoceptor agonists |
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| Q33775572 | Thyrotropin (TSH) receptor residue E251 in the extracellular leucine-rich repeat domain is critical for linking TSH binding to receptor activation |
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| Q34111760 | Toward structure determination using membrane-protein nanocrystals and microcrystals |
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| Q42240327 | Toward the three-dimensional structure and lysophosphatidic acid binding characteristics of the LPA(4)/p2y(9)/GPR23 receptor: a homology modeling study |
| Q34611560 | Towards improved quality of GPCR models by usage of multiple templates and profile-profile comparison |
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| Q43112410 | Two amino acid substitutions within the first external loop of CCR5 induce human immunodeficiency virus-blocking antibodies in mice and chickens |
| Q37081904 | Two arginine-glutamate ionic locks near the extracellular surface of FFAR1 gate receptor activation. |
| Q34663887 | Understanding cadherin EGF LAG seven-pass G-type receptors. |
| Q27687653 | Understanding functional residues of the cannabinoid CB1. |
| Q42064855 | Unique interaction pattern for a functionally biased ghrelin receptor agonist |
| Q26852233 | Unlocking the secrets of the gatekeeper: methods for stabilizing and crystallizing GPCRs |
| Q30383769 | Unraveling the structure and function of G protein-coupled receptors through NMR spectroscopy. |
| Q104473866 | Use of cyclic peptides to induce crystallization: case study with prolyl hydroxylase domain 2 |
| Q36829195 | Use of multidimensional fluorescence resonance energy transfer to establish the orientation of cholecystokinin docked at the type A cholecystokinin receptor |
| Q30384065 | Visualizing water molecules in transmembrane proteins using radiolytic labeling methods. |
| Q52346929 | Vitamin E-based glycoside amphiphiles for membrane protein structural studies. |
| Q38680670 | What Do Structures Tell Us About Chemokine Receptor Function and Antagonism? |
| Q34981578 | Why we need many more G protein-coupled receptor structures |
| Q30397964 | X-ray diffraction from membrane protein nanocrystals |
| Q38093833 | X-ray structural information of GPCRs in drug design: what are the limitations and where do we go? |
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| Q33989429 | ss-TEA: Entropy based identification of receptor specific ligand binding residues from a multiple sequence alignment of class A GPCRs |
| Q37102508 | β-arrestin-biased signaling through the β2-adrenergic receptor promotes cardiomyocyte contraction |
| Q41367007 | β1-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes |
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