Recent advances in structure-based virtual screening of G-protein coupled receptors

scientific article published on 17 March 2009

Recent advances in structure-based virtual screening of G-protein coupled receptors is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1003823475
P356DOI10.1208/S12248-009-9094-3
P932PMC publication ID2664893
P698PubMed publication ID19291412
P5875ResearchGate publication ID24205706

P2093author name stringWei Zhang
Subramaniam Ananthan
Judith Varady Hobrath
P2860cites workHigh-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptorQ24657484
Crystal structure of rhodopsin: A G protein-coupled receptorQ27625972
Advances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)Q27632765
Crystal structure of the human beta2 adrenergic G-protein-coupled receptorQ27648868
A Specific Cholesterol Binding Site Is Established by the 2.8 Å Structure of the Human β2-Adrenergic ReceptorQ27650801
Crystal structure of the ligand-free G-protein-coupled receptor opsinQ27650885
Structure of a beta1-adrenergic G-protein-coupled receptorQ27651011
Crystal structure of opsin in its G-protein-interacting conformationQ27652301
GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor functionQ28254935
A combined ligand-based and target-based drug design approach for G-protein coupled receptors: application to salvinorin A, a selective kappa opioid receptor agonist.Q30357121
Structure-based virtual screening of chemical libraries for drug discoveryQ33242317
Virtual ligand screening: strategies, perspectives and limitationsQ33247681
Development and application of hybrid structure based method for efficient screening of ligands binding to G-protein coupled receptorsQ33260986
GPCR structure-based virtual screening approach for CB2 antagonist searchQ33288322
Modulating G-protein coupled receptor/G-protein signal transduction by small molecules suggested by virtual screeningQ33360557
Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screeningQ34776186
I want a new drug: G-protein-coupled receptors in drug developmentQ36483932
Discovery of novel agonists and antagonists of the free fatty acid receptor 1 (FFAR1) using virtual screeningQ37013424
A virtual screen for diverse ligands: discovery of selective G protein-coupled receptor antagonistsQ39999810
Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets?Q44242205
Use of the X-ray structure of the beta2-adrenergic receptor for drug discovery. Part 2: Identification of active compoundsQ46336635
Selective structure-based virtual screening for full and partial agonists of the beta2 adrenergic receptorQ46445968
Virtual screening of biogenic amine-binding G-protein coupled receptors: comparative evaluation of protein- and ligand-based virtual screening protocolsQ46655989
Binding mode analysis and enrichment studies on homology models of the human histamine H4 receptorQ46977726
Discovery of novel chemotypes to a G-protein-coupled receptor through ligand-steered homology modeling and structure-based virtual screening.Q51791975
Homology model-based virtual screening for GPCR ligands using docking and target-biased scoringQ53037530
Use of the X-ray structure of the Beta2-adrenergic receptor for drug discoveryQ80616052
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
protein structureQ735188
virtual screeningQ4112105
P304page(s)178-185
P577publication date2009-03-17
P13046publication type of scholarly workreview articleQ7318358
P1433published inThe AAPS JournalQ10695361
P1476titleRecent advances in structure-based virtual screening of G-protein coupled receptors
P478volume11

Reverse relations

cites work (P2860)
Q36088280Differential Virtual Screening (DVS) with Active and Inactive Molecular Models for Finding and Profiling GPCR Modulators: Case of the CCK1 Receptor
Q35840893How well do the substrates KISS the enzyme? Molecular docking program selection for feruloyl esterases.
Q64092935ImmtorLig_DB: repertoire of virtually screened small molecules against immune receptors to bolster host immunity
Q45943415Methods for Virtual Screening of GPCR Targets: Approaches and Challenges.
Q41617618Monte Carlo loop refinement and virtual screening of the thyroid-stimulating hormone receptor transmembrane domain
Q39152860Recent Advances and Applications of Molecular Docking to G Protein-Coupled Receptors
Q35962179Structure-Based Virtual Screening for Dopamine D2 Receptor Ligands as Potential Antipsychotics
Q38028544Systems biology visualization tools for drug target discovery
Q33640639Using ligand-based virtual screening to allosterically stabilize the activated state of a GPCR.

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