The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling (scientific article)

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The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling is …

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P819	ADS bibcode	2012NatCo...3.1044B
P6179	Dimensions Publication ID	1046138584
P356	DOI	10.1038/NCOMMS2028
P932	PMC publication ID	3658004
P698	PubMed publication ID	22948826
P5875	ResearchGate publication ID	230797734

P50

author

Ulrike Holzgrabe

Andreas Bock

Clelia Dallanoce

Marco De Amici

Carlo Matera

author name string

Evi Kostenis

Anke Müller

Carsten Hoffmann

Jens Schmitz

Klaus Mohr

Christian Tränkle

Lucas Peters

Nicole Merten

Jessica Klöckner

Ramona Schrage

Julia Bätz

Katharina Simon

Anna Kebig

Jasmin Schrobang-Ley

P2860

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Allosteric Modulation of G Protein–Coupled Receptors

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Modification of the binding properties of muscarinic receptors by gallamine

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Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

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Allosteric interactions with muscarinic acetylcholine receptors: complex role of the conserved tryptophan M2422Trp in a critical cluster of amino acids for baseline affinity, subtype selectivity, and cooperativity

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Muscarinic acetylcholine receptors: mutant mice provide new insights for drug development

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Heterotrimeric G protein activation by G-protein-coupled receptors

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When simple agonism is not enough: emerging modalities of GPCR ligands.

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The best of both worlds? Bitopic orthosteric/allosteric ligands of g protein-coupled receptors

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A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation

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The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation

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A novel mechanism of G protein-coupled receptor functional selectivity. Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand.

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Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-o

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Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors

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Inhibition of the actions of carbachol and DFP on guinea pig isolated atria by alkane-bis-ammonium compounds

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A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cells

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Critical amino acid residues of the common allosteric site on the M2 muscarinic acetylcholine receptor: more similarities than differences between the structurally divergent agents gallamine and bis(ammonio)alkane-type hexamethylene-bis-[dimethyl-(3

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Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation

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Functional reconstitution of purified muscarinic receptors and inhibitory guanine nucleotide regulatory protein.

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P275

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

copyrighted

language of work or name

English

Q1860

P921

main subject

transmembrane protein

Q424204

P304

page(s)

1044

P577

publication date

2012-01-01

P1433

published in

Nature Communications

Q573880

P1476

title

The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling

P478

volume

Reverse relations

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