Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation (scientific article published on 21 September 2007)

Modes of allosteric interactions with free and [3H]N-methylscopolamine-occupied muscarinic M2 receptors as deduced from buffer-dependent potency shifts

Q31804644

Uncovering molecular mechanisms involved in activation of G protein-coupled receptors

Q33851363

Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

Q34139176

G protein-coupled receptor allosterism and complexing

Q34523552

Seven-transmembrane receptors: crystals clarify

Q34552623

The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice

Q35733326

Molecular mechanism of 7TM receptor activation--a global toggle switch model

Q36364704

Allosteric agonists of 7TM receptors: expanding the pharmacological toolbox

Q36556801

Essential role for the second extracellular loop in C5a receptor activation

Q40446589

Allosteric site on muscarinic acetylcholine receptors: a single amino acid in transmembrane region 7 is critical to the subtype selectivities of caracurine V derivatives and alkane-bisammonium ligands

Q43830232

Molecular recognition of receptor sites using a genetic algorithm with a description of desolvation

Q43987901

Systematic development of high affinity bis(ammonio)alkane-type allosteric enhancers of muscarinic ligand binding

Q44348675

Measurement of the millisecond activation switch of G protein-coupled receptors in living cells

Q44479240

Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-o

Q44483391

Development of a new type of allosteric modulator of muscarinic receptors: hybrids of the antagonist AF-DX 384 and the hexamethonio derivative W84.

Q44910631

The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure

Q45029374

Muscarinic allosteric enhancers of ligand binding: pivotal pharmacophoric elements in hexamethonio-type agents

Q46383182

Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy

Q46387086

Allosteric binding sites on muscarinic acetylcholine receptors

Q46720566

Allosteric site in M2 acetylcholine receptors: evidence for a major conformational change upon binding of an orthosteric agonist instead of an antagonist

Q46857215

GROMACS 3.0: a package for molecular simulation and trajectory analysis

Q57082068

Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands

Q57838214

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

G protein-coupled receptor

Q38173

transmembrane protein

Q424204

P1104

number of pages

P304

page(s)

34968-34976

P577

publication date

2007-09-21

P1433

published in

Journal of Biological Chemistry

Q867727

P1476

title

Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activation

P478

volume

282

Reverse relations

cites work (P2860)

Q39615485	A fluorescence resonance energy transfer-based M2 muscarinic receptor sensor reveals rapid kinetics of allosteric modulation
Q36836367	Agonists with supraphysiological efficacy at the muscarinic M2 ACh receptor.
Q34539431	Allosteric transition: a comparison of two models
Q39248479	Allostery at opioid receptors: modulation with small molecule ligands.
Q39827491	An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators
Q28468325	Binding of N-methylscopolamine to the extracellular domain of muscarinic acetylcholine receptors
Q42937057	Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.
Q42694873	Distinct second extracellular loop structures of the brain cannabinoid CB(1) receptor: implication in ligand binding and receptor function
Q33520987	Divergence of allosteric effects of rapacuronium on binding and function of muscarinic receptors
Q46405402	Dualsteric modulators of the M2 muscarinic acetylcholine receptor.
Q54629048	Dynamic ligand binding dictates partial agonism at a G protein-coupled receptor.
Q33748133	Identification of orthosteric and allosteric site mutations in M2 muscarinic acetylcholine receptors that contribute to ligand-selective signaling bias
Q42933080	Ligand entry and exit pathways in the beta2-adrenergic receptor
Q38066121	Molecular alliance-from orthosteric and allosteric ligands to dualsteric/bitopic agonists at G protein coupled receptors
Q37111743	Molecular properties of muscarinic acetylcholine receptors
Q43084203	On homology modeling of the M₂ muscarinic acetylcholine receptor subtype.
Q47301262	Pharmacological Evidence for a Putative Conserved Allosteric Site on Opioid Receptors.
Q27027736	Positive allosteric modulators of the μ-opioid receptor: a novel approach for future pain medications
Q37688232	Rational design of dualsteric GPCR ligands: quests and promise
Q39341570	Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity.
Q24595276	Structural model of ligand-G protein-coupled receptor (GPCR) complex based on experimental double mutant cycle data: MT7 snake toxin bound to dimeric hM1 muscarinic receptor
Q34297570	The allosteric vestibule of a seven transmembrane helical receptor controls G-protein coupling
Q33888491	Tyrosine 308 is necessary for ligand-directed Gs protein-biased signaling of β2-adrenoceptor
Q27687653	Understanding functional residues of the cannabinoid CB1.

P356	DOI	10.1074/JBC.M705563200
P698	PubMed publication ID	17890226