An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators

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An optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1080/10799890903047437
P698PubMed publication ID19586284

P2093author name stringEvi Kostenis
Klaus Mohr
Anna Kebig
Marion Mohr-Andrä
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Collateral efficacy in drug discovery: taking advantage of the good (allosteric) nature of 7TM receptorsQ36880900
Muscarinic acetylcholine receptors: mutant mice provide new insights for drug developmentQ36925551
Dualsteric GPCR targeting: a novel route to binding and signaling pathway selectivityQ39931162
Estimation of agonist activity at G protein-coupled receptors: analysis of M2 muscarinic receptor signaling through Gi/o,Gs, and G15.Q40152913
Non-invasive optical biosensor for assaying endogenous G protein-coupled receptors in adherent cells.Q40185924
Resonant waveguide grating biosensor for living cell sensing.Q40269125
Allosteric regulation of cloned m1–m5 muscarinic receptor subtypesQ41660421
An investigation of whether agonist-selective receptor conformations occur with respect to M2 and M4 muscarinic acetylcholine receptor signalling via Gi/o and Gs proteinsQ41869522
Non-invasive Optical Biosensor for Probing Cell Signaling.Q42122607
Evaluation of dynamic mass redistribution technology for pharmacological studies of recombinant and endogenously expressed g protein-coupled receptorsQ43646655
Allosteric site on muscarinic acetylcholine receptors: a single amino acid in transmembrane region 7 is critical to the subtype selectivities of caracurine V derivatives and alkane-bisammonium ligandsQ43830232
Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-oQ44483391
Functional selectivity of GPCR ligand stereoisomers: new pharmacological opportunitiesQ46253304
Design, synthesis, and action of oxotremorine-related hybrid-type allosteric modulators of muscarinic acetylcholine receptorsQ46879304
Synthesis and functional characterization of novel derivatives related to oxotremorine and oxotremorine-M.Q46907066
Allosteric small molecules unveil a role of an extracellular E2/transmembrane helix 7 junction for G protein-coupled receptor activationQ46985701
Muscarinic M2 receptors directly activate Gq/11 and Gs G-proteins.Q51802778
P433issue3-4
P921main subjectG protein-coupled receptorQ38173
biasQ742736
P304page(s)140-145
P577publication date2009-01-01
P1433published inJournal of Receptors and Signal TransductionQ6295837
P1476titleAn optical dynamic mass redistribution assay reveals biased signaling of dualsteric GPCR activators
P478volume29

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cites work (P2860)
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Q58856223M1 muscarinic cetylcholine receptor allosteric modulators as potential therapeutic opportunities for treating Alzheimer's disease
Q38218059Muscarinic acetylcholine receptors: novel opportunities for drug development
Q34343837PROBING CANCER SIGNALING WITH RESONANT WAVEGUIDE GRATING BIOSENSORS
Q39288199Pro-fibrotic processes in human lung fibroblasts are driven by an autocrine/paracrine endothelinergic system
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Q47685791The development of label-free cellular assays for drug discovery
Q39538307The β2-subtype of adrenoceptors mediates inhibition of pro-fibrotic events in human lung fibroblasts

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