| scholarly article | Q13442814 |
| P50 | author | Marta Filizola | Q41045386 |
| P2093 | author name string | Yi Shang | |
| Kristen A Marino | |||
| P2860 | cites work | Structure of the human κ-opioid receptor in complex with JDTic | Q24308048 |
| Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists | Q24619974 | ||
| Structure-based discovery of opioid analgesics with reduced side effects | Q26331003 | ||
| Molecular switches of the κ opioid receptor triggered by 6'-GNTI and 5'-GNTI. | Q27302413 | ||
| Preferred supramolecular organization and dimer interfaces of opioid receptors from simulated self-association | Q27319797 | ||
| Structural basis for bifunctional peptide recognition at human δ-opioid receptor | Q27644624 | ||
| Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions | Q27670746 | ||
| Structure and dynamics of the M3 muscarinic acetylcholine receptor | Q27677433 | ||
| Crystal structure of the µ-opioid receptor bound to a morphinan antagonist | Q27678133 | ||
| Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic | Q27679151 | ||
| Structure of the δ-opioid receptor bound to naltrindole | Q27679153 | ||
| Structure of the CCR5 Chemokine Receptor-HIV Entry Inhibitor Maraviroc Complex | Q27679932 | ||
| Molecular control of δ-opioid receptor signalling | Q27681274 | ||
| On the modularity of the intrinsic flexibility of the µ opioid receptor: a computational study | Q28542919 | ||
| The Concise Guide to PHARMACOLOGY 2015/16: G protein-coupled receptors | Q28552564 | ||
| The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands | Q28603128 | ||
| AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility | Q29547658 | ||
| Pathway and mechanism of drug binding to G-protein-coupled receptors. | Q30503489 | ||
| Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures | Q30712788 | ||
| A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor | Q33885350 | ||
| Allosteric sodium in class A GPCR signaling | Q33931569 | ||
| Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions | Q34041202 | ||
| Escaping free-energy minima | Q34151010 | ||
| Making structural sense of dimerization interfaces of delta opioid receptor homodimers | Q34160481 | ||
| Palmitoylation and membrane cholesterol stabilize μ-opioid receptor homodimerization and G protein coupling. | Q34201750 | ||
| A G Protein-Biased Ligand at the μ-Opioid Receptor Is Potently Analgesic with Reduced Gastrointestinal and Respiratory Dysfunction Compared with Morphine | Q34321618 | ||
| Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity | Q34354902 | ||
| Structural insights into µ-opioid receptor activation | Q34488374 | ||
| The Dynamic Process of Drug-GPCR Binding at Either Orthosteric or Allosteric Sites Evaluated by Metadynamics | Q34489039 | ||
| The Importance of Ligand-Receptor Conformational Pairs in Stabilization: Spotlight on the N/OFQ G Protein-Coupled Receptor | Q34500216 | ||
| Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2. | Q34538336 | ||
| Synthetic Studies of Neoclerodane Diterpenes from Salvia divinorum: Identification of a Potent and Centrally Acting μ Opioid Analgesic with Reduced Abuse Liability. | Q34547230 | ||
| Differential stability of the crystallographic interfaces of mu- and kappa-opioid receptors | Q35126350 | ||
| NbIT--a new information theory-based analysis of allosteric mechanisms reveals residues that underlie function in the leucine transporter LeuT. | Q35160636 | ||
| Emerging roles for lipids in shaping membrane-protein function. | Q35203586 | ||
| Structural Determinants for the Binding of Morphinan Agonists to the μ-Opioid Receptor | Q35747694 | ||
| Structural determinants of the supramolecular organization of G protein-coupled receptors in bilayers. | Q36120778 | ||
| Dynamic Cholesterol-Conditioned Dimerization of the G Protein Coupled Chemokine Receptor Type 4. | Q36182026 | ||
| Impact of Lipid Composition and Receptor Conformation on the Spatio-temporal Organization of μ-Opioid Receptors in a Multi-component Plasma Membrane Model | Q36222134 | ||
| Opioid doses required for pain management in lung cancer patients with different cholesterol levels: negative correlation between opioid doses and cholesterol levels | Q36662387 | ||
| Nociceptin/Orphanin FQ Receptor Structure, Signaling, Ligands, Functions, and Interactions with Opioid Systems | Q36744366 | ||
| Structural Mechanisms of Voltage Sensing in G Protein-Coupled Receptors | Q37000273 | ||
| Ligands that interact with putative MOR-mGluR5 heteromer in mice with inflammatory pain produce potent antinociception. | Q37010754 | ||
| Proposed Mode of Binding and Action of Positive Allosteric Modulators at Opioid Receptors | Q37108546 | ||
| The role of a sodium ion binding site in the allosteric modulation of the A(2A) adenosine G protein-coupled receptor | Q37381287 | ||
| G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives | Q37680849 | ||
| Cholesterol modulates the dimer interface of the β₂-adrenergic receptor via cholesterol occupancy sites | Q37700209 | ||
| Structural insights into agonist-induced activation of G-protein-coupled receptors | Q37896916 | ||
| Uncovering the intimate relationship between lipids, cholesterol and GPCR activation | Q37950728 | ||
| G-protein coupled receptors: advances in simulation and drug discovery | Q38848557 | ||
| Molecular dynamics-driven drug discovery: leaping forward with confidence | Q39021656 | ||
| A Dynamic Picture of the Early Events in Nociceptin Binding to the NOP Receptor by Metadynamics | Q39366509 | ||
| Constitutive activation of the mu opioid receptor by mutation of D3.49(164), but not D3.32(147): D3.49(164) is critical for stabilization of the inactive form of the receptor and for its expression. | Q40777582 | ||
| Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. | Q40803165 | ||
| Molecular details of the activation of the μ opioid receptor. | Q41899831 | ||
| Functional role of a conserved motif in TM6 of the rat mu opioid receptor: constitutively active and inactive receptors result from substitutions of Thr6.34(279) with Lys and Asp. | Q42512456 | ||
| What can we learn from molecular dynamics simulations for GPCR drug design? | Q43155783 | ||
| The local environment at the cytoplasmic end of TM6 of the mu opioid receptor differs from those of rhodopsin and monoamine receptors: introduction of an ionic lock between the cytoplasmic ends of helices 3 and 6 by a L6.30(275)E mutation inactivate | Q44160462 | ||
| The role of water and sodium ions in the activation of the μ-opioid receptor | Q44340498 | ||
| How Oliceridine (TRV-130) Binds and Stabilizes a μ-Opioid Receptor Conformational State That Selectively Triggers G Protein Signaling Pathways | Q44340976 | ||
| Conformational Heterogeneity of Intracellular Loop 3 of the μ-opioid G-protein Coupled Receptor | Q44341109 | ||
| Sodium regulation of agonist binding at opioid receptors. II. Effects of sodium replacement on opioid binding in guinea pig cortical membranes | Q44347007 | ||
| The mechanism of ligand-induced activation or inhibition of μ- and κ-opioid receptors. | Q44351255 | ||
| Lipid organization of the plasma membrane | Q46837671 | ||
| Identification of novel high affinity opiate receptor binding in rat brain | Q48476166 | ||
| Opiate agonists and antagonists discriminated by receptor binding in brain | Q48611095 | ||
| Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs. | Q50470980 | ||
| ROSETTALIGAND: protein-small molecule docking with full side-chain flexibility | Q51933455 | ||
| Opioid Receptors | Q52307702 | ||
| Functional role of the "ionic lock"--an interhelical hydrogen-bond network in family A heptahelical receptors. | Q52587486 | ||
| G Protein-Coupled Receptors Self-Assemble in Dynamics Simulations of Model Bilayers | Q59176772 | ||
| The nociceptin receptor (NOPR) and its interaction with clinically important agonist molecules: a membrane molecular dynamics simulation study | Q85641570 | ||
| P433 | issue | 14 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | opioid | Q427523 |
| crystal structure | Q895901 | ||
| P304 | page(s) | 2834-2845 | |
| P577 | publication date | 2017-04-12 | |
| P1433 | published in | British Journal of Pharmacology | Q919631 |
| P1476 | title | Insights into the function of opioid receptors from molecular dynamics simulations of available crystal structures | |
| P478 | volume | 175 |
| Q47348631 | Computational Methods Used in Hit-to-Lead and Lead Optimization Stages of Structure-Based Drug Discovery |
| Q90131372 | Computer simulations of protein-membrane systems |
| Q41200379 | Dynamic and Kinetic Elements of µ-Opioid Receptor Functional Selectivity |
| Q89232453 | Emerging areas of opioid pharmacology |
| Q41722010 | Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure-Activity Relationships. |
| Q41037577 | Hurdles in Basic Science Translation |
| Q48020118 | Molecular Dynamics Methodologies for Probing Cannabinoid Ligand/Receptor Interaction |
| Q90713873 | N-Phenethyl Substitution in 14-Methoxy-N-methylmorphinan-6-ones Turns Selective µ Opioid Receptor Ligands into Dual µ/δ Opioid Receptor Agonists |
| Q93017246 | Recent Insights from Molecular Dynamics Simulations for G Protein-Coupled Receptor Drug Discovery |
| Q58581253 | Repurposing of a Nucleoside Scaffold from Adenosine Receptor Agonists to Opioid Receptor Antagonists |
Search more.