Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure-Activity Relationships.

scientific article published on 21 August 2017

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Highly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure-Activity Relationships. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/ACS.JMEDCHEM.7B00981
P932PMC publication ID5601360
P698PubMed publication ID28825813

P50authorMariana SpeteaQ38545108
Helmut SchmidhammerQ57234666
P2093author name stringAquilino Lantero
Elena Guerrieri
Tanila Ben Haddou
Filippo Erli
Michael Mairegger
P2860cites workStructure of the human κ-opioid receptor in complex with JDTicQ24308048
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Salvinorin A, a kappa-opioid receptor agonist hallucinogen: pharmacology and potential template for novel pharmacotherapeutic agents in neuropsychiatric disordersQ26781580
κ-opioid receptor/dynorphin system: genetic and pharmacotherapeutic implications for addictionQ26864309
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
Antagonists of the kappa opioid receptorQ28237246
Novel developments with selective, non-peptidic kappa-opioid receptor agonistsQ28259198
Discovery and Pharmacological Evaluation of a Diphenethylamine Derivative (HS665), a Highly Potent and Selective κ Opioid Receptor AgonistQ28278823
Will peripherally restricted kappa-opioid receptor agonists (pKORAs) relieve pain with less opioid adverse effects and abuse potential?Q30250027
Neuropharmacology of the Naturally Occurring κ-Opioid Hallucinogen Salvinorin AQ30467220
30 years of dynorphins--new insights on their functions in neuropsychiatric diseasesQ30481450
Peptide kappa opioid receptor ligands: potential for drug developmentQ33442900
Opioids: first lessons from knockout miceQ33547877
Selective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice.Q33911524
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[3H]U-69593 a highly selective ligand for the opioid kappa receptorQ42204885
Structural determinants of diphenethylamines for interaction with the κ opioid receptor: Synthesis, pharmacology and molecular modeling studiesQ44339731
Kappa Opioid Receptor Activation in Dopamine Neurons Disrupts Behavioral InhibitionQ44346829
Synthesis and pharmacological evaluation of [(3)H]HS665, a novel, highly selective radioligand for the kappa opioid receptor.Q44348699
A simplified method of evaluating dose-effect experimentsQ80391249
P433issue17
P407language of work or nameEnglishQ1860
P304page(s)7579-7590
P577publication date2017-08-30
P1433published inJournal of Medicinal ChemistryQ900316
P1476titleHighly Potent and Selective New Diphenethylamines Interacting with the κ-Opioid Receptor: Synthesis, Pharmacology, and Structure-Activity Relationships
P478volume60

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cites work (P2860)
Q64105404A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists
Q52317568Structurally-Related Kappa Opioid Receptor Agonists with Substantial Differential Signaling Bias: Neuroendocrine and Behavioral Effects in C57BL6 Mice
Q57095558and Pharmacological Activities of 14--Phenylpropyloxymorphone, a Potent Mixed Mu/Delta/Kappa-Opioid Receptor Agonist With Reduced Constipation in Mice

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