Structural Mechanisms of Voltage Sensing in G Protein-Coupled Receptors

scientific article published on 11 May 2016

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Structural Mechanisms of Voltage Sensing in G Protein-Coupled Receptors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.STR.2016.04.007
P932PMC publication ID4906246
P698PubMed publication ID27210286

P50authorJan-Philipp MachtensQ58237481
Owen N VickeryQ58237488
Ulrich ZachariaeQ28355623
P2093author name stringDaniel Seeliger
Giulia Tamburrino
P2860cites workActivation and allosteric modulation of a muscarinic acetylcholine receptorQ24308061
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Sensitivity limits for voltage control of P2Y receptor-evoked Ca2+ mobilization in the rat megakaryocyteQ79331068
Activation of G-protein-coupled receptors correlates with the formation of a continuous internal water pathwayQ85277884
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Structural diversity of G protein-coupled receptors and significance for drug discoveryQ29616716
Seven-transmembrane receptorsQ29619896
g_membed: Efficient insertion of a membrane protein into an equilibrated lipid bilayer with minimal perturbationQ30387289
Voltage affects the dissociation rate constant of the m2 muscarinic receptorQ31137990
Allosteric sodium in class A GPCR signalingQ33931569
Mechanistic insights into the allosteric modulation of opioid receptors by sodium ionsQ34041202
Electrical Spiking in Escherichia coli Probed with a Fluorescent Voltage-Indicating ProteinQ34201140
Influence of dendritic conductances on the input-output properties of neuronsQ34345448
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Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulationsQ34794503
Proton transfer-mediated GPCR activationQ34854983
Allosteric effects of sodium ion binding on activation of the m3 muscarinic g-protein-coupled receptorQ35333859
Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activationQ35590341
Depolarization induces a conformational change in the binding site region of the M 2 muscarinic receptorQ35657854
Can energy landscape roughness of proteins and RNA be measured by using mechanical unfolding experiments?Q35917424
Voltage regulates adrenergic receptor functionQ36567891
The role of internal water molecules in the structure and function of the rhodopsin family of G protein-coupled receptorsQ36685974
GPCR activation: protonation and membrane potentialQ36922998
Initial response of the potassium channel voltage sensor to a transmembrane potentialQ37156485
A role for membrane potential in regulating GPCRs?Q37214078
Pore waters regulate ion permeation in a calcium release-activated calcium channelQ37255879
The roles of K(+) channels in cancerQ38171243
Modulation of GPCRs by monovalent cations and anions.Q38272337
Insights into the function of ion channels by computational electrophysiology simulationsQ38732214
Selective enhancement of [3H]opiate agonist binding by divalent cationsQ39363678
Direct measurement of protein energy landscape roughnessQ40110910
The mode of agonist binding to a G protein-coupled receptor switches the effect that voltage changes have on signalingQ40358357
Molecular dynamics simulations of a fluid bilayer of dipalmitoylphosphatidylcholine at full hydration, constant pressure, and constant temperatureQ41775672
The M2 muscarinic G-protein-coupled receptor is voltage-sensitiveQ42439480
Sodium ion binding pocket mutations and adenosine A2A receptor function.Q42469733
Conformational changes in the M2 muscarinic receptor induced by membrane voltage and agonist bindingQ48682233
Movement of 'gating charge' is coupled to ligand binding in a G-protein-coupled receptorQ50643404
P433issue6
P921main subjectvoltageQ25428
G protein-coupled receptorQ38173
P304page(s)997-1007
P577publication date2016-05-11
P1433published inStructureQ15709970
P1476titleStructural Mechanisms of Voltage Sensing in G Protein-Coupled Receptors
P478volume24

Reverse relations

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Q46445025D4 dopamine receptor high-resolution structures enable the discovery of selective agonists.
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Q92132459Helix 8 is the essential structural motif of mechanosensitive GPCRs
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Q26740438Membrane potentials regulating GPCRs: insights from experiments and molecular dynamics simulations
Q91867447Presynaptic Mechanisms and KCNQ Potassium Channels Modulate Opioid Depression of Respiratory Drive
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Q44346788Two delta opioid receptor subtypes are functional in single ventral tegmental area neurons, and can interact with the mu opioid receptor

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