β-Arrestin-Biased Agonists of the GLP-1 Receptor from β-Amino Acid Residue Incorporation into GLP-1 Analogues.

scientific article published on 4 November 2016

β-Arrestin-Biased Agonists of the GLP-1 Receptor from β-Amino Acid Residue Incorporation into GLP-1 Analogues. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1021/JACS.6B08323
P932PMC publication ID5207657
P698PubMed publication ID27813409

P50authorPatrick M. SextonQ39936838
Denise WoottenQ43294588
P2093author name stringSamuel H Gellman
Lisa M Johnson
Marlies V Hager
P2860cites workA Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal StructuresQ27345100
Structural and biological mimicry of protein surface recognition by  / -peptide foldamersQ27657158
Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 ReceptorQ27657999
Crystal Structures of a Stabilized β1-Adrenoceptor Bound to the Biased Agonists Bucindolol and CarvedilolQ27679036
The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased AgonismQ28276469
Characterization of glucagon-like peptide-1 receptor beta-arrestin 2 interaction: a high-affinity receptor phenotypeQ28291820
Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administrationQ28378259
GLP-1 mediates antiapoptotic effect by phosphorylating Bad through a beta-arrestin 1-mediated ERK1/2 activation in pancreatic beta-cellsQ28506327
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Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.Q35454522
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activationQ35763258
Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) differentially regulates orthosteric but not allosteric agonist binding and function.Q35763289
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Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated MiceQ36373813
Beta-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic beta cellsQ36638807
Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformationsQ36729833
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A review of exenatide as adjunctive therapy in patients with type 2 diabetesQ37403218
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Signalling bias in new drug discovery: detection, quantification and therapeutic impact.Q38081692
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Optical Control of Insulin Secretion Using an Incretin Switch.Q38818301
Structural requirements of the N-terminal region of GLP-1-[7-37]-NH2 for receptor interaction and cAMP production.Q40548199
Dipeptidyl peptidase IV resistant analogues of glucagon-like peptide-1 which have extended metabolic stability and improved biological activityQ41051549
Glucagon-like peptide-1-(7-36)amide is transformed to glucagon-like peptide-1-(9-36)amide by dipeptidyl peptidase IV in the capillaries supplying the L cells of the porcine intestine.Q42479294
Emergent biological properties of arrestin pathway-selective biased agonismQ46960983
Oxyntomodulin and glucagon-like peptide-1 differentially regulate murine food intake and energy expenditureQ47945051
A new GLP-1 analogue with prolonged glucose-lowering activity in vivo via backbone-based modification at the N-terminus.Q50878317
Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands.Q51755093
β-Arrestin1-mediated recruitment of c-Src underlies the proliferative action of glucagon-like peptide-1 in pancreatic β INS832/13 cells.Q54486729
Characterisation of the processing by human neutral endopeptidase 24.11 of GLP-1(7-36) amide and comparison of the substrate specificity of the enzyme for other glucagon-like peptidesQ70942068
Oxyntomodulin differentially affects glucagon-like peptide-1 receptor beta-arrestin recruitment and signaling through Galpha(s)Q80065293
P433issue45
P407language of work or nameEnglishQ1860
P304page(s)14970-14979
P577publication date2016-11-04
P1433published inJournal of the American Chemical SocietyQ898902
P1476titleβ-Arrestin-Biased Agonists of the GLP-1 Receptor from β-Amino Acid Residue Incorporation into GLP-1 Analogues
P478volume138

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Q96132105Advances in therapeutic peptides targeting G protein-coupled receptors
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Q89520120Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking

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