Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex. (scientific article published on 21 February 2018)

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

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Crystal structure of the ligand-bound glucagon-like peptide-1 receptor extracellular domain

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Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)

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The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

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Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor

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Automated electron microscope tomography using robust prediction of specimen movements

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Volta potential phase plate for in-focus phase contrast transmission electron microscopy.

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Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: implications for drug screening.

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Second extracellular loop of human glucagon-like peptide-1 receptor (GLP-1R) has a critical role in GLP-1 peptide binding and receptor activation

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Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic effects

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Polar transmembrane interactions drive formation of ligand-specific and signal pathway-biased family B G protein-coupled receptor conformations

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Peptide binding at the GLP-1 receptor.

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Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2.

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Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein

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Phase-plate cryo-EM structure of a class B GPCR-G-protein complex

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MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

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Gctf: Real-time CTF determination and correction

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Identification of effector-activating residues of Gs alpha

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Residues within the transmembrane domain of the glucagon-like peptide-1 receptor involved in ligand binding and receptor activation: modelling the ligand-bound receptor

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β-Arrestin-Biased Agonists of the GLP-1 Receptor from β-Amino Acid Residue Incorporation into GLP-1 Analogues.

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The G226A mutant of Gs alpha highlights the requirement for dissociation of G protein subunits

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Crystal structure of the GLP-1 receptor bound to a peptide agonist.

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Ligand-Dependent Modulation of G Protein Conformation Alters Drug Efficacy.

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Differential activation and modulation of the glucagon-like peptide-1 receptor by small molecule ligands.

Q51755093

P433

issue

7694

P407

language of work or name

English

Q1860

P921

main subject

cryogenic electron microscopy

Q5190506

P304

page(s)

121-125

P577

publication date

2018-02-21

P1433

published in

Nature

Q180445

P1476

title

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.

P478

volume

555

Reverse relations

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P356	DOI	10.1038/NATURE25773
P2888	exact match	https://scigraph.springernature.com/pub.10.1038/nature25773
P698	PubMed publication ID	29466332