An online resource for GPCR structure determination and analysis

scientific article published on 21 January 2019

An online resource for GPCR structure determination and analysis is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1111348294
P356DOI10.1038/S41592-018-0302-X
P932PMC publication ID6881186
P698PubMed publication ID30664776

P50authorRaymond C. StevensQ7298638
Christian MunkQ57189205
Louise F NikolajsenQ57189221
Janne M. BibbeQ63385213
David E. GloriamQ42265596
Xavier DeupíQ56152998
Eshita MuttQ57008044
P2093author name stringMichael A Hanson
Vignir Isberg
Tilman Flock
P2860cites workA helix propensity scale based on experimental studies of peptides and proteinsQ24537262
Crystal structure of the β2 adrenergic receptor-Gs protein complexQ24635327
Large-scale production and protein engineering of G protein-coupled receptors for structural studiesQ26866010
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Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laserQ27644398
GPCRdb: the G protein-coupled receptor database - an introductionQ28077608
Generic GPCR residue numbers - aligning topology maps while minding the gapsQ28087587
SignalP 4.0: discriminating signal peptides from transmembrane regionsQ29547202
Structure-function of the G protein-coupled receptor superfamilyQ30576993
Crystal structure of rhodopsin in complex with a mini-G sheds light on the principles of G protein selectivityQ58718025
Cryo-EM structure of human rhodopsin bound to an inhibitory G proteinQ59060428
Cryo-EM structure of the serotonin 5-HT receptor coupled to heterotrimeric GQ59060460
Structure of the adenosine-bound human adenosine A1 receptor–Gi complexQ59060936
Activation of the A2A adenosine G-protein-coupled receptor by conformational selectionQ59070946
Integrating structural and mutagenesis data to elucidate GPCR ligand binding.Q31118641
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Structural Insights into the Dynamic Process of β2-Adrenergic Receptor SignalingQ35638953
Fusion partner toolchest for the stabilization and crystallization of G protein-coupled receptorsQ36033453
Co-evolving stability and conformational homogeneity of the human adenosine A2a receptorQ36825295
In vitro expression and analysis of the 826 human G protein-coupled receptorsQ36858819
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activationQ37127495
Ligand binding and micro-switches in 7TM receptor structuresQ37449971
Control of the negative IRES trans-acting factor KHSRP by ubiquitinationQ37577374
Biased ligands at G-protein-coupled receptors: promise and progressQ38216119
Active state structures of G protein-coupled receptors highlight the similarities and differences in the G protein and arrestin coupling interfacesQ39291009
Applying Structure-Based Drug Design Approaches to Allosteric Modulators of GPCRsQ39397224
Opportunities for therapeutic antibodies directed at G-protein-coupled receptorsQ39433833
Stabilization of the human beta2-adrenergic receptor TM4-TM3-TM5 helix interface by mutagenesis of Glu122(3.41), a critical residue in GPCR structureQ40020328
Cryo-EM structure of haemoglobin at 3.2 Å determined with the Volta phase plate.Q40964898
Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplexQ41596694
Cryo-EM structure of the activated GLP-1 receptor in complex with a G proteinQ41597824
Phase-plate cryo-EM structure of a class B GPCR-G-protein complexQ41598194
The DynaMine webserver: predicting protein dynamics from sequenceQ42279450
Origin of the different strengths of the (i,i+4) and (i,i+3) leucine pair interactions in helicesQ44009104
GPCRdb in 2018: adding GPCR structure models and ligands.Q47105885
Trends in GPCR drug discovery: new agents, targets and indications.Q47597808
5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology.Q49344600
Gi- and Gs-coupled GPCRs show different modes of G-protein bindingQ49790548
Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR SignalingQ50207906
Crystal structure of the GLP-1 receptor bound to a peptide agonist.Q50968563
Selectivity determinants of GPCR-G-protein binding.Q51010606
Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor-Gs complex.Q52375459
The importance of ligands for G protein-coupled receptor stability.Q53634312
Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein.Q55072103
GPCRdb: an information system for G protein-coupled receptors.Q55096303
Structure of the µ-opioid receptor–Gi protein complexQ56674183
Editorial overview: New technologies: GPCR drug design and function — exploiting the current (of) structuresQ56987429
Cryo-EM in drug discovery: achievements, limitations and prospectsQ57178721
P433issue2
P921main subjectbiotechnologyQ7108
P304page(s)151-162
P577publication date2019-01-21
P1433published inNature MethodsQ680640
P1476titleAn online resource for GPCR structure determination and analysis
P478volume16

Reverse relations

cites work (P2860)
Q92966015Adhesion G protein-coupled receptors: opportunities for drug discovery
Q97424458Allosteric interactions in the parathyroid hormone GPCR-arrestin complex formation
Q93180359Allosteric modulation of G protein-coupled receptors by amiloride and its derivatives. Perspectives for drug discovery?
Q92881989Allosteric modulation of β-cell M3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese mice
Q83224304Common activation mechanism of class A GPCRs
Q83231443Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit
Q97531549GPCRmd uncovers the dynamics of the 3D-GPCRome
Q104073522Integrative modeling of membrane-associated protein assemblies
Q91710471Mechanistic Insights into Specific G Protein Interactions with Adenosine Receptors
Q64103530MultiBac: Baculovirus-Mediated Multigene DNA Cargo Delivery in Insect and Mammalian Cells
Q89792288Structural basis of ligand recognition and self-activation of orphan GPR52
Q90713562Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins
Q64068088Understanding Ligand Binding to G-Protein Coupled Receptors Using Multiscale Simulations

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