| scholarly article | Q13442814 |
| P50 | author | Jens Meiler | Q29315318 |
| Anita Preininger | Q43164356 | ||
| P2093 | author name string | Heidi E Hamm | |
| P2860 | cites work | Structure of an agonist-bound human A2A adenosine receptor | Q24296388 |
| Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation | Q24303747 | ||
| The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor | Q24594844 | ||
| Structure of a nanobody-stabilized active state of the β(2) adrenoceptor | Q24597139 | ||
| Structure and function of an irreversible agonist-β(2) adrenoceptor complex | Q24620291 | ||
| Crystal structure of the β2 adrenergic receptor-Gs protein complex | Q24635327 | ||
| Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations | Q24645752 | ||
| The 2.6 angstrom crystal structure of a human A2A adenosine receptor bound to an antagonist | Q24654563 | ||
| Crystal structure of rhodopsin: A G protein-coupled receptor | Q27625972 | ||
| Crystal structure of the human beta2 adrenergic G-protein-coupled receptor | Q27648868 | ||
| Crystal structure of the ligand-free G-protein-coupled receptor opsin | Q27650885 | ||
| Structure of a beta1-adrenergic G-protein-coupled receptor | Q27651011 | ||
| Crystal structure of opsin in its G-protein-interacting conformation | Q27652301 | ||
| Helix Dipole Movement and Conformational Variability Contribute to Allosteric GDP Release in Gα i Subunits † , ‡ | Q27653830 | ||
| Structural evidence for a sequential release mechanism for activation of heterotrimeric G proteins | Q27657143 | ||
| Conserved Binding Mode of Human β 2 Adrenergic Receptor Inverse Agonists and Antagonist Revealed by X-ray Crystallography | Q27663654 | ||
| Crystal structure of metarhodopsin II | Q27666911 | ||
| The structural basis of agonist-induced activation in constitutively active rhodopsin | Q27667245 | ||
| Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions | Q27670746 | ||
| Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis | Q27730891 | ||
| The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S | Q27731495 | ||
| Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS | Q27748762 | ||
| Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor. Expression and mutational analysis of synthetic receptor genes | Q28240879 | ||
| The second intracellular loop of the m5 muscarinic receptor is the switch which enables G-protein coupling | Q28281974 | ||
| Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor | Q28294870 | ||
| GDP release preferentially occurs on the phosphate side in heterotrimeric G-proteins | Q28481401 | ||
| Molecular simulations and solid-state NMR investigate dynamical structure in rhodopsin activation | Q30406132 | ||
| Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution | Q30413000 | ||
| Single amino acid substitutions and deletions that alter the G protein coupling properties of the V2 vasopressin receptor identified in yeast by receptor random mutagenesis | Q30662392 | ||
| Internal hydration increases during activation of the G-protein-coupled receptor rhodopsin | Q31160779 | ||
| A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor | Q33885350 | ||
| The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gαi1. | Q33996965 | ||
| Molecular signatures of G-protein-coupled receptors | Q34327700 | ||
| Structural determinants in the second intracellular loop of the human cannabinoid CB1 receptor mediate selective coupling to Gs and Gi | Q34442426 | ||
| Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins | Q34554804 | ||
| Local peptide movement in the photoreaction intermediate of rhodopsin | Q35021777 | ||
| Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit | Q35034989 | ||
| Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activation pathway | Q35133731 | ||
| Structural flexibility of the G alpha s alpha-helical domain in the beta2-adrenoceptor Gs complex | Q35229205 | ||
| Activation mechanism of the β2-adrenergic receptor | Q35558683 | ||
| Ligand-specific interactions modulate kinetic, energetic, and mechanical properties of the human β2 adrenergic receptor | Q35863890 | ||
| Agonist dynamics and conformational selection during microsecond simulations of the A(2A) adenosine receptor | Q35926130 | ||
| Conformational dynamics of activation for the pentameric complex of dimeric G protein-coupled receptor and heterotrimeric G protein | Q35957944 | ||
| Conformational changes in the G protein Gs induced by the β2 adrenergic receptor | Q36252945 | ||
| Cholesterol heterogeneity in bovine rod outer segment disk membranes | Q36483416 | ||
| Cholesterol increases kinetic, energetic, and mechanical stability of the human β2-adrenergic receptor. | Q36483829 | ||
| The dynamic process of β(2)-adrenergic receptor activation | Q36651876 | ||
| The highly conserved DRY motif of class A G protein-coupled receptors: beyond the ground state. | Q36693902 | ||
| Predictions for cholesterol interaction sites on the A2A adenosine receptor | Q36838702 | ||
| Conformational complexity of G-protein-coupled receptors | Q36880905 | ||
| Linking receptor activation to changes in Sw I and II of Gα proteins | Q37053797 | ||
| From valleys to ridges: exploring the dynamic energy landscape of single membrane proteins. | Q37112719 | ||
| Role of the extracellular loops of G protein-coupled receptors in ligand recognition: a molecular modeling study of the human P2Y1 receptor. | Q37143313 | ||
| Structural basis for ligand binding and specificity in adrenergic receptors: implications for GPCR-targeted drug discovery. | Q37281064 | ||
| Recent progress in the study of G protein-coupled receptors with molecular dynamics computer simulations | Q37858664 | ||
| Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor. | Q38289177 | ||
| Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX. | Q38462134 | ||
| Evaluating cellular impedance assays for detection of GPCR pleiotropic signaling and functional selectivity | Q39884754 | ||
| Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function | Q39943167 | ||
| Activation of the beta 2-adrenergic receptor involves disruption of an ionic lock between the cytoplasmic ends of transmembrane segments 3 and 6. | Q40803165 | ||
| G alpha minigenes expressing C-terminal peptides serve as specific inhibitors of thrombin-mediated endothelial activation | Q40818013 | ||
| Hydrophobic amino acid in the i2 loop plays a key role in receptor-G protein coupling. | Q41519901 | ||
| Dynamic structure of retinylidene ligand of rhodopsin probed by molecular simulations | Q41771911 | ||
| Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR. | Q41775482 | ||
| Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins. | Q41838778 | ||
| Interruption of the ionic lock in the bradykinin B2 receptor results in constitutive internalization and turns several antagonists into strong agonists | Q42514634 | ||
| A concerted mechanism for opening the GDP binding pocket and release of the nucleotide in hetero-trimeric G-proteins | Q42604469 | ||
| Concerted interconversion between ionic lock substates of the beta(2) adrenergic receptor revealed by microsecond timescale molecular dynamics | Q42844366 | ||
| Impact of the DRY motif and the missing "ionic lock" on constitutive activity and G-protein coupling of the human histamine H4 receptor | Q43182572 | ||
| Rapid activation of transducin by mutations distant from the nucleotide-binding site: evidence for a mechanistic model of receptor-catalyzed nucleotide exchange by G proteins | Q43610785 | ||
| Disruption of the alpha5 helix of transducin impairs rhodopsin-catalyzed nucleotide exchange | Q44008700 | ||
| Molecular dynamics simulations of the adenosine A2a receptor: structural stability, sampling, and convergence. | Q44228364 | ||
| Reconstitution reveals additional roles for N- and C-terminal domains of g(alpha) in muscarinic receptor coupling | Q44479702 | ||
| Rhodopsin activation exposes a key hydrophobic binding site for the transducin alpha-subunit C terminus | Q44834954 | ||
| Conformational changes associated with receptor-stimulated guanine nucleotide exchange in a heterotrimeric G-protein alpha-subunit: NMR analysis of GTPgammaS-bound states | Q46890300 | ||
| Potent peptide analogues of a G protein receptor-binding region obtained with a combinatorial library | Q46989688 | ||
| Molecular dynamics simulations of transducin: interdomain and front to back communication in activation and nucleotide exchange. | Q47772278 | ||
| Activation of Gi protein by peptide structures of the muscarinic M2 receptor second intracellular loop | Q48139595 | ||
| The metabotropic glutamate receptors: their second intracellular loop plays a critical role in the G-protein coupling specificity. | Q49067385 | ||
| Two amino acids within the alpha4 helix of Galphai1 mediate coupling with 5-hydroxytryptamine1B receptors | Q57129658 | ||
| Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands | Q57838214 | ||
| Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit | Q70399454 | ||
| A novel site on the Galpha -protein that recognizes heptahelical receptors | Q73067495 | ||
| Phenylalanine 138 in the second intracellular loop of human thromboxane receptor is critical for receptor-G-protein coupling | Q73098013 | ||
| The N-terminal extension of Galphaq is critical for constraining the selectivity of receptor coupling | Q73541773 | ||
| Molecular aspects of vasopressin receptor function | Q74457839 | ||
| Roles of the transducin alpha-subunit alpha4-helix/alpha4-beta6 loop in the receptor and effector interactions | Q74602426 | ||
| The receptor-bound "empty pocket" state of the heterotrimeric G-protein alpha-subunit is conformationally dynamic | Q79292619 | ||
| The membrane complex between transducin and dark-state rhodopsin exhibits large-amplitude interface dynamics on the sub-microsecond timescale: insights from all-atom MD simulations | Q83035606 | ||
| P433 | issue | 13 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | G protein-coupled receptor | Q38173 |
| P304 | page(s) | 2288-2298 | |
| P577 | publication date | 2013-04-16 | |
| P1433 | published in | Journal of Molecular Biology | Q925779 |
| P1476 | title | Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective | |
| P478 | volume | 425 |
| Q49344600 | 5-HT2C Receptor Structures Reveal the Structural Basis of GPCR Polypharmacology. |
| Q51052184 | A conformation-equilibrium model captures ligand-ligand interactions and ligand-biased signalling by G-protein coupled receptors. |
| Q28543750 | A dynamic view of molecular switch behavior at serotonin receptors: implications for functional selectivity |
| Q28249697 | A functional selectivity mechanism at the serotonin-2A GPCR involves ligand-dependent conformations of intracellular loop 2 |
| Q27681985 | A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1. |
| Q47979078 | Activation processes in ligand-activated G protein-coupled receptors: A case study of the adenosine A2A receptor |
| Q35188726 | Active-state model of a dopamine D2 receptor-Gαi complex stabilized by aripiprazole-type partial agonists |
| Q91958978 | Assembly of a GPCR-G Protein Complex |
| Q35134557 | Bacterial chemoreceptor dynamics correlate with activity state and are coupled over long distances |
| Q91156903 | Biased Agonist TRV027 Determinants in AT1R by Molecular Dynamics Simulations |
| Q35752199 | Biased signaling: potential agonist and antagonist of PAR2. |
| Q30368025 | Chemistry and biology of the initial steps in vision: the Friedenwald lecture. |
| Q48118681 | Comprehensive analysis of sphingosine-1-phosphate receptor mutants during zebrafish embryogenesis |
| Q28265667 | Conformational states of the full-length glucagon receptor |
| Q41151319 | Conformational thermostabilisation of corticotropin releasing factor receptor 1. |
| Q36394992 | Crucial role of the orexin-B C-terminus in the induction of OX1 receptor-mediated apoptosis: analysis by alanine scanning, molecular modelling and site-directed mutagenesis. |
| Q60921876 | Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists |
| Q35198382 | Crystallization scale preparation of a stable GPCR signaling complex between constitutively active rhodopsin and G-protein |
| Q52604833 | Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor. |
| Q37626332 | Energetic analysis of the rhodopsin-G-protein complex links the α5 helix to GDP release |
| Q30394046 | Exploring the mechanism of F282L mutation-caused constitutive activity of GPCR by a computational study |
| Q42699012 | Frustration-guided motion planning reveals conformational transitions in proteins |
| Q38211688 | Harnessing allostery: a novel approach to drug discovery |
| Q89982570 | Heterotrimeric Gq proteins as therapeutic targets? |
| Q43182019 | In vitro screening of major neurotransmitter systems possibly involved in the mechanism of action of antibodies to S100 protein in released-active form. |
| Q91710471 | Mechanistic Insights into Specific G Protein Interactions with Adenosine Receptors |
| Q34041202 | Mechanistic insights into the allosteric modulation of opioid receptors by sodium ions |
| Q64086965 | Molecular Dynamics Simulations of the Allosteric Modulation of the Adenosine A2A Receptor by a Mini-G Protein |
| Q28546825 | Nullspace Sampling with Holonomic Constraints Reveals Molecular Mechanisms of Protein Gαs |
| Q36096058 | Opioid receptors: Structural and mechanistic insights into pharmacology and signaling |
| Q35611767 | Quantifying conformational changes in GPCRs: glimpse of a common functional mechanism. |
| Q64229278 | Rational design of a heterotrimeric G protein α subunit with artificial inhibitor sensitivity |
| Q37551902 | Recent Progress in Understanding the Conformational Mechanism of Heterotrimeric G Protein Activation |
| Q91620038 | Recent advances in computational studies of GPCR-G protein interactions |
| Q64282228 | Receptor selectivity between the G proteins Gα and Gα is defined by a single leucine-to-isoleucine variation |
| Q56979785 | Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding |
| Q42694413 | Structural Basis for G Protein-Coupled Receptor Activation |
| Q28237034 | Structural approaches to understanding retinal proteins needed for vision |
| Q33931230 | Structural basis of G protein-coupled receptor-Gi protein interaction: formation of the cannabinoid CB2 receptor-Gi protein complex |
| Q96640363 | Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family |
| Q49895947 | Tauroursodeoxycholic acid binds to the G-protein site on light activated rhodopsin. |
| Q44441472 | The future of drug discovery: enabling technologies for enhancing lead characterization and profiling therapeutic potential |
| Q50249181 | The nucleotide-free state of heterotrimeric G proteins α-subunit adopts a highly stable conformation. |
| Q92616378 | The steroid hormone 20-hydroxyecdysone binds to dopamine receptor to repress lepidopteran insect feeding and promote pupation |
| Q64998361 | Tracking yeast pheromone receptor Ste2 endocytosis using fluorogen-activating protein tagging. |
| Q36269542 | Unifying view of mechanical and functional hotspots across class A GPCRs. |
| Q36899633 | Universal allosteric mechanism for Gα activation by GPCRs |
| Q43155783 | What can we learn from molecular dynamics simulations for GPCR drug design? |
Search more.