Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor

scientific article published on 09 October 2013

Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M113.520791
P932PMC publication ID3829169
P698PubMed publication ID24108126

P2093author name stringFulong Tan
Xianming Zhang
Randal A Skidgel
P2860cites workSequence of human carboxypeptidase D reveals it to be a member of the regulatory carboxypeptidase family with three tandem active site domainsQ24530524
Allostery at G protein-coupled receptor homo- and heteromers: uncharted pharmacological landscapesQ24633877
The crystal structure of the inhibitor-complexed carboxypeptidase D domain II and the modeling of regulatory carboxypeptidasesQ27630916
Crystal structure of the human carboxypeptidase N (kininase I) catalytic domainQ27643263
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptorQ27646733
Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and NQ28115355
Release of glycosylphosphatidylinositol-anchored carboxypeptidase M by phosphatidylinositol-specific phospholipase C upregulates enzyme synthesisQ28142723
International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequencesQ28237006
Human carboxypeptidase M. Purification and characterization of a membrane-bound carboxypeptidase that cleaves peptide hormonesQ28284348
Extracellular conversion of epidermal growth factor (EGF) to des-Arg53-EGF by carboxypeptidase MQ28293648
Renal protective role of bradykinin B1 receptor in stroke-prone spontaneously hypertensive ratsQ28580783
The role of bradykinin B1 receptor on cardiac remodeling in stroke-prone spontaneously hypertensive rats (SHR-SP)Q28584037
The human B1 bradykinin receptor exhibits high ligand-independent, constitutive activity. Roles of residues in the fourth intracellular and third transmembrane domainsQ31778105
The 7 TM G-protein-coupled receptor target familyQ33253601
Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor functionQ33623829
Differential regulation of inducible and endothelial nitric oxide synthase by kinin B1 and B2 receptorsQ33695494
Arteriogenesis is modulated by bradykinin receptor signalingQ33947750
Key role for spinal dorsal horn microglial kinin B1 receptor in early diabetic pain neuropathyQ34036011
Carboxypeptidases from A to z: implications in embryonic development and Wnt bindingQ34107145
Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptorQ34117188
Basic carboxypeptidases: regulators of peptide hormone activityQ34165149
Molecular signatures of G-protein-coupled receptorsQ34327700
gp180, a protein that binds duck hepatitis B virus particles, has metallocarboxypeptidase D-like enzymatic activityQ34462491
Enhanced Co2+ activation and inhibitor binding of carboxypeptidase M at low pH. Similarity to carboxypeptidase H (enkephalin convertase).Q34542853
Cross-talk between carboxypeptidase M and the kinin B1 receptor mediates a new mode of G protein-coupled receptor signalingQ34998057
Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptorsQ35177694
Domain coupling in GPCRs: the engine for induced conformational changesQ35740222
Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injuryQ35757535
Genetically altered animal models in the kallikrein-kinin systemQ36404457
Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide outputQ36593321
Kinins and cardiovascular diseases.Q36612056
Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathyQ37193691
The kinin B1 receptor contributes to the cardioprotective effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in miceQ37286766
Carboxypeptidase M: Multiple alliances and unknown partners.Q37310571
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disordersQ37360436
'7TM receptor allostery: putting numbers to shapeshifting proteinsQ37591623
Fine-tuning of GPCR activity by receptor-interacting proteinsQ37638132
Strategies for the identification of allosteric modulators of G-protein-coupled receptorsQ37823926
Renin-angiotensin-aldosterone blockade for cardiovascular disease preventionQ37831670
Kinins as therapeutic agents in cardiovascular and renal diseasesQ37897613
Lifting the lid on GPCRs: the role of extracellular loopsQ37921853
Allostery in GPCRs: 'MWC' revisited.Q37932797
Emerging opportunities for allosteric modulation of G-protein coupled receptorsQ38043240
Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonistsQ40026619
FRET-based monitoring of conformational change of the beta2 adrenergic receptor in living cellsQ40297402
Essential role for the second extracellular loop in C5a receptor activationQ40446589
Mutation of tyrosine in the conserved NPXXY sequence leads to constitutive phosphorylation and internalization, but not signaling, of the human B2 bradykinin receptorQ40552036
Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonistsQ40665846
Structure of the human carboxypeptidase M gene. Identification of a proximal GC-rich promoter and a unique distal promoter that consists of repetitive elements.Q40745050
Replacement of the transmembrane anchor in angiotensin I-converting enzyme (ACE) with a glycosylphosphatidylinositol tail affects activation of the B2 bradykinin receptor by ACE inhibitorsQ40889449
Carboxypeptidase M in Madin-Darby canine kidney cells. Evidence that carboxypeptidase M has a phosphatidylinositol glycan anchorQ41721929
Cellular carboxypeptidasesQ41745113
Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoringQ43002720
Hydrolysis of opioid hexapeptides by carboxypeptidase N. Presence of carboxypeptidase in cell membranesQ44330775
Selective kinin receptor agonists as cardioprotective agents in myocardial ischemia and diabetesQ44501148
Mechanisms Mediating the Vasoactive Effects of the B 1 Receptors of BradykininQ44616354
The bradykinin B1 receptor contributes to the cardioprotective effects of AT1 blockade after experimental myocardial infarctionQ44763885
Carboxypeptidase-mediated enhancement of nitric oxide production in rat lungs and microvascular endothelial cellsQ44772514
Targeting kinin B(1) receptor for therapeutic neovascularizationQ45882818
A FlAsH-based FRET approach to determine G protein-coupled receptor activation in living cellsQ46396170
Angiotensin-converting enzyme inhibition after experimental myocardial infarct: role of the kinin B1 and B2 receptorsQ46696407
Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activityQ47812636
Increased susceptibility to endotoxic shock in transgenic rats with endothelial overexpression of kinin B(1) receptors.Q52918922
Allosteric Modulation of G Protein–Coupled ReceptorsQ56115675
Mice deficient for both kinin receptors are normotensive and protected from endotoxin-induced hypotensionQ56963424
Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor LigandsQ57838214
B1 Bradykinin Receptors and Carboxypeptidase M Are Both Upregulated in the Aorta of Pigs after LPS InfusionQ58898541
Human carboxypeptidase MQ72059274
Structure and mechanism of metallocarboxypeptidasesQ79661978
Bioluminescence resonance energy transfer (BRET) for the real-time detection of protein-protein interactionsQ80092854
Mechanism of GPCR-directed autoantibodies in diseasesQ84371824
P433issue46
P407language of work or nameEnglishQ1860
P1104number of pages15
P304page(s)33226-33240
P577publication date2013-10-09
P1433published inJournal of Biological ChemistryQ867727
P1476titleCarboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor
P478volume288

Reverse relations

cites work (P2860)
Q96304846Angiotensin-Converting Enzyme Inhibitor Protects Against Cisplatin Nephrotoxicity by Modulating Kinin B1 Receptor Expression and Aminopeptidase P Activity in Mice
Q92545200Binding to carboxypeptidase M mediates protective effects of fibrinopeptide Bβ15-42
Q34617439Downregulation of kinin B1 receptor function by B2 receptor heterodimerization and signaling
Q64131833Functional variant of the carboxypeptidase M (CPM) gene may affect silica-related pneumoconiosis susceptibility by its expression: a multistage case-control study
Q38837708HAE Pathophysiology and Underlying Mechanisms.
Q47370922Kinin B1 receptors as a therapeutic target for inflammation
Q38616792Kininase 1 As a Preclinical Therapeutic Target for Kinin B1 Receptor in Insulin Resistance
Q38631744Optical probes based on G protein-coupled receptors - added work or added value?
Q35563944Proteomics of the human endometrial glandular epithelium and stroma from the proliferative and secretory phases of the menstrual cycle
Q44748766Substrate specificity of human metallocarboxypeptidase D: Comparison of the two active carboxypeptidase domains.
Q39364225The Effect of Kinin B1 Receptor on Chronic Itching Sensitization
Q38818947The effect of kinin B1 receptor on chronic itching sensitization

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