scholarly article | Q13442814 |
P50 | author | Christopher J Langmead | Q88424187 |
Stephen J. Hill | Q37828928 | ||
Jeanette Woolard | Q44377018 | ||
Fiona H. Marshall | Q53997636 | ||
P2093 | author name string | Ali Jazayeri | |
Andrei Zhukov | |||
Malcolm Weir | |||
Markus Koglin | |||
Catherine J Hutchings | |||
Gabriella Cseke | |||
Greg Osborne | |||
Jahnavi Pandya-Pathak | |||
P2860 | cites work | Constitutive dimerization of the G-protein coupled receptor, neurotensin receptor 1, reconstituted into phospholipid bilayers | Q24644172 |
High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor | Q24657484 | ||
Opportunities for functional selectivity in GPCR antibodies | Q26859602 | ||
Structure of a beta1-adrenergic G-protein-coupled receptor | Q27651011 | ||
Structure of the Adenosine A2A Receptor in Complex with ZM241385 and the Xanthines XAC and Caffeine | Q27672832 | ||
Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor | Q27678197 | ||
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction | Q27860958 | ||
The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway | Q28145398 | ||
Allosteric modulation of the cannabinoid CB1 receptor | Q28268355 | ||
Importance of the extracellular loops in G protein-coupled receptors for ligand recognition and receptor activation | Q30522852 | ||
Nanodisc-incorporated hemagglutinin provides protective immunity against influenza virus infection | Q33558691 | ||
Anti-CXCR4 monoclonal antibodies recognizing overlapping epitopes differ significantly in their ability to inhibit entry of human immunodeficiency virus type 1. | Q33718391 | ||
Antigenically distinct conformations of CXCR4. | Q33845055 | ||
Mapping of a functional autoimmune epitope on the beta 1-adrenergic receptor in patients with idiopathic dilated cardiomyopathy | Q34263678 | ||
Therapeutic antibodies directed at G protein-coupled receptors | Q34445135 | ||
beta(1)-Adrenergic receptor function, autoimmunity, and pathogenesis of dilated cardiomyopathy. | Q34651493 | ||
Analysis of G-protein-coupled receptor dimerization following chemokine signaling | Q34826248 | ||
Critical Role for the Second Extracellular Loop in the Binding of Both Orthosteric and Allosteric G Protein-coupled Receptor Ligands | Q57838214 | ||
First report of anti-calcium-sensing receptor antibodies in a patient with Sjogren's syndrome and primary hypoparathyroidism | Q64041696 | ||
Modification of the binding properties of muscarinic receptors by gallamine | Q71773661 | ||
Modulation of beta1-adrenoceptor activity by domain-specific antibodies and heart failure-associated autoantibodies | Q73069755 | ||
Interaction between autoantibodies against the beta1-adrenoceptor and isoprenaline in enhancing L-type Ca2+ current in rat ventricular myocytes | Q80062004 | ||
[Antibodies against the second extracellular loop of beta1-adrenergic receptor induce aortic endothelial dysfunction in Wistar rat] | Q84223698 | ||
Mechanism of GPCR-directed autoantibodies in diseases | Q84371824 | ||
Administration of the cyclic peptide COR-1 in humans (phase I study): ex vivo measurements of anti-β1-adrenergic receptor antibody neutralization and of immune parameters | Q84962464 | ||
Biopharmaceutical benchmarks 2010 | Q85008502 | ||
Antibodies to cardiac receptors | Q85539839 | ||
A pharmacological primer of biased agonism | Q35238406 | ||
G-protein coupled receptors as allosteric machines | Q35809338 | ||
Virus-like display of a neo-self antigen reverses B cell anergy in a B cell receptor transgenic mouse model | Q36383391 | ||
Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7. | Q36446506 | ||
The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2 | Q36447255 | ||
Conformational thermostabilization of the beta1-adrenergic receptor in a detergent-resistant form | Q36458843 | ||
Serum agonistic autoantibodies against type-1 angiotensin II receptor titer in patients with epithelial ovarian cancer: a potential role in tumor cell migration and angiogenesis | Q36767058 | ||
Production of antibodies against multipass membrane proteins expressed in human tumor cells using dendritic cell immunization | Q37158844 | ||
Targeting receptor antibodies in immune cardiomyopathy | Q37736349 | ||
G protein-coupled receptors: novel targets for drug discovery in cancer | Q37824814 | ||
Progress in structure based drug design for G protein-coupled receptors | Q37880053 | ||
Drug-like actions of autoantibodies against receptors of the autonomous nervous system and their impact on human heart function | Q37973384 | ||
Potential use of G protein-coupled receptor-blocking monoclonal antibodies as therapeutic agents for cancers | Q38011387 | ||
Generation of functional antibodies for mammalian membrane protein crystallography | Q38105711 | ||
Measurements of β-arrestin recruitment to activated seven transmembrane receptors using enzyme complementation | Q39335768 | ||
Characterization of G-protein coupled receptor modulators using homogeneous cAMP assays | Q39335775 | ||
β1 -adrenergic receptor autoantibodies from heart failure patients enhanced TNF-α secretion in RAW264.7 macrophages in a largely PKA-dependent fashion | Q39342487 | ||
Production of human antibodies to native cytokine receptors using the genetic immunization of KM mice | Q39803822 | ||
Exosome nanovesicles displaying G protein-coupled receptors for drug discovery. | Q40023482 | ||
Anti-beta1-adrenergic receptor autoantibodies are potent stimulators of the ERK1/2 pathway in cardiac cells | Q40107520 | ||
Essential role for the second extracellular loop in C5a receptor activation | Q40446589 | ||
Predicting in vivo cardiovascular properties of β-blockers from cellular assays: a quantitative comparison of cellular and cardiovascular pharmacological responses. | Q42191909 | ||
Marketed therapeutic antibodies compendium | Q43141598 | ||
The calcium-sensing receptor is a target of autoantibodies in patients with autoimmune polyendocrine syndrome type 1. | Q43717357 | ||
Chemokine receptor dimerization: two are better than one. | Q43792050 | ||
Allosteric site on muscarinic acetylcholine receptors: identification of two amino acids in the muscarinic M2 receptor that account entirely for the M2/M5 subtype selectivities of some structurally diverse allosteric ligands in N-methylscopolamine-o | Q44483391 | ||
Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods. | Q46016726 | ||
The thyrotropin (TSH) receptor: interaction with TSH and autoantibodies | Q46228305 | ||
Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist | Q46738214 | ||
The influence of drug-like concepts on decision-making in medicinal chemistry | Q46922861 | ||
Enhancement of antibody responses to native G protein-coupled receptors using E. coli GroEL as a molecular adjuvant in DNA immunization. | Q54347789 | ||
Ventricular arrhythmias are related to the presence of autoantibodies with adrenergic activity in chronic chagasic patients with preserved left ventricular function. | Q54417655 | ||
Pro-apoptotic effect of anti-β1-adrenergic receptor antibodies in periodontitis patients. | Q54474836 | ||
Allosteric Modulation of G Protein–Coupled Receptors | Q56115675 | ||
P433 | issue | 1 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | antibody | Q79460 |
P304 | page(s) | 246-261 | |
P577 | publication date | 2014-01-01 | |
P1433 | published in | Monoclonal Antibodies | Q6714645 |
P1476 | title | Monoclonal anti-β1-adrenergic receptor antibodies activate G protein signaling in the absence of β-arrestin recruitment | |
P478 | volume | 6 |
Q47441641 | A monoclonal antibody raised against a thermo-stabilised β1-adrenoceptor interacts with extracellular loop 2 and acts as a negative allosteric modulator of a sub-set of β1-adrenoceptors expressed in stable cell lines. |
Q54203028 | A targeted boost-and-sort immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies. |
Q36213478 | Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1 |
Q50887597 | Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges. |
Q35933820 | Antibody Engineering & Therapeutics, the annual meeting of The Antibody Society December 7-10, 2015, San Diego, CA, USA. |
Q26781607 | Challenges and opportunities for non-antibody scaffold drugs |
Q37141597 | DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops |
Q38282832 | Discovery of functional antibodies targeting ion channels |
Q95294055 | Generating therapeutic monoclonal antibodies to complex multi-spanning membrane targets: Overcoming the antigen challenge and enabling discovery strategies |
Q35972482 | Generation of Recombinant Monoclonal Antibodies from Immunised Mice and Rabbits via Flow Cytometry and Sorting of Antigen-Specific IgG+ Memory B Cells |
Q38289992 | New horizons in therapeutic antibody discovery: opportunities and challenges versus small-molecule therapeutics |
Q39433833 | Opportunities for therapeutic antibodies directed at G-protein-coupled receptors |
Q94445335 | Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies |
Q95282452 | Unmasking features of the auto-epitope essential for β1 -adrenoceptor activation by autoantibodies in chronic heart failure |
Search more.