U2 snRNP is required for expression of the 3' end of genes

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U2 snRNP is required for expression of the 3' end of genes is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...998015K
P356DOI10.1371/JOURNAL.PONE.0098015
P932PMC publication ID4028248
P698PubMed publication ID24845214
P5875ResearchGate publication ID262539052

P50authorMinoru YoshidaQ37370114
Daisuke KaidaQ40104435
P2093author name stringIchiro Takasaki
Takayuki Satoh
Mitsunori Koga
Yumi Kawamura
P2860cites workNew antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of actionQ73070075
Nucleosomes can form a polar barrier to transcript elongation by RNA polymerase IIQ79326024
Nature of the nucleosomal barrier to RNA polymerase IIQ81610323
The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicingQ21090175
Proteomic analysis identifies a new complex required for nuclear pre-mRNA retention and splicingQ24317157
A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch siteQ24522607
Pause sites promote transcriptional termination of mammalian RNA polymerase IIQ24548945
Targeted 'knockdown' of spliceosome function in mammalian cellsQ24556613
U1 snRNP determines mRNA length and regulates isoform expressionQ24623251
3' end mRNA processing: molecular mechanisms and implications for health and diseaseQ24648650
The role of chromatin during transcriptionQ27860995
Identification of a regulated pathway for nuclear pre-mRNA turnover.Q27931532
The 3' to 5' degradation of yeast mRNAs is a general mechanism for mRNA turnover that requires the SKI2 DEVH box protein and 3' to 5' exonucleases of the exosome complexQ27934144
Nuclear retention of unspliced mRNAs in yeast is mediated by perinuclear Mlp1.Q27939910
The spliceosome: design principles of a dynamic RNP machineQ28131809
SR proteins collaborate with 7SK and promoter-associated nascent RNA to release paused polymeraseQ28512917
U1 snRNP protects pre-mRNAs from premature cleavage and polyadenylationQ29032058
Elongation by RNA polymerase II: the short and long of itQ29614529
Pre-mRNA processing reaches back to transcription and ahead to translationQ29615045
Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II.Q34252430
Rules of engagement: co-transcriptional recruitment of pre-mRNA processing factorsQ34419716
Pre-mRNA splicing is a determinant of histone H3K36 methylationQ35170883
Processing the message: structural insights into capping and decapping mRNA.Q36046476
Extensive degradation of RNA precursors by the exosome in wild-type cellsQ36392961
Cross-talks between transcription and post-transcriptional events within a 'mRNA factory'.Q36849100
The splicing factor SC35 has an active role in transcriptional elongationQ36952048
Mechanisms of RNA degradation by the eukaryotic exosomeQ37714460
NMD: RNA biology meets human genetic medicineQ37783315
RNA polymerase II elongation controlQ37992154
A splicing-dependent transcriptional checkpoint associated with prespliceosome formation.Q38787111
Multiple factors in the early splicing complex are involved in the nuclear retention of pre-mRNAs in mammalian cellsQ39471849
Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3' end of human genesQ39479568
Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA.Q40104313
A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicingQ40370412
MAZ elements alter transcription elongation and silencing of the fibroblast growth factor receptor 2 exon IIIbQ40559049
Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin AQ42146150
Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF.Q42476005
RNA polymerase backtracking in gene regulation and genome instabilityQ42924286
New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activitiesQ44729411
A movie of RNA polymerase II transcriptionQ48424870
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)e98015
P577publication date2014-05-20
P1433published inPLOS OneQ564954
P1476titleU2 snRNP is required for expression of the 3' end of genes
P478volume9

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cites work (P2860)
Q27308081A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans
Q38712211Discoveries, target identifications, and biological applications of natural products that inhibit splicing factor 3B subunit 1.
Q36165982Global analysis of pre-mRNA subcellular localization following splicing inhibition by spliceostatin A.
Q47121434Molecular basis of differential 3' splice site sensitivity to anti-tumor drugs targeting U2 snRNP.
Q37225467Overexpression of USP39 predicts poor prognosis and promotes tumorigenesis of prostate cancer via promoting EGFR mRNA maturation and transcription elongation
Q38749631Posttranscriptional mechanisms controlling diurnal gene expression cycles by body temperature rhythms
Q38935296Splicing inhibition decreases phosphorylation level of Ser2 in Pol II CTD.
Q49866056Targeting cleavage and polyadenylation specific factor 1 via shRNA inhibits cell proliferation in human ovarian cancer
Q37343029Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp

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