Why did p53 gene therapy fail in ovarian cancer?

scientific article

Why did p53 gene therapy fail in ovarian cancer? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S1470-2045(03)01139-2
P698PubMed publication ID12850192

P2093author name stringAlain G Zeimet
Christian Marth
P2860cites workp63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activitiesQ22003973
Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor geneQ28215782
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5Q28303765
An anti-apoptotic role for the p53 family member, p73, during developmental neuron deathQ28505615
Mechanism of the combination effect of wild-type TP53 gene transfection and cisplatin treatment for ovarian cancer xenograftsQ64380477
Mutated p21(WAF1/CIP1/SDI1) lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cellsQ74261370
p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumoursQ28513003
Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachmentQ29615852
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6Q29622924
The effects of the adenovirus-mediated wild-type p53 delivery in human epithelial ovarian cancer cell line in vitro and in vivoQ30307979
Inactivation of the apoptosis effector Apaf-1 in malignant melanomaQ31984891
Effect of p53 gene transfer and cisplatin in a peritonitis carcinomatosa model with p53-deficient ovarian cancer cellsQ33183313
An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanismQ33786008
Disruption of p53 in human cancer cells alters the responses to therapeutic agentsQ33853609
DNA hypermethylation in tumorigenesis: epigenetics joins geneticsQ33870798
New insights into p53 regulation and gene therapy for cancer.Q34047246
p53: death starQ34103258
Epigenetic downregulation of the retinoic acid receptor-beta2 gene in breast cancer.Q34334842
Transcriptional targeting for ovarian cancer gene therapyQ34352401
Apoptosis: a link between cancer genetics and chemotherapyQ34520432
Genetic and immunologic therapies for lung cancerQ34563734
Adenoviral vector-mediated gene transfer for human gene therapyQ34729274
Switching from life to death: the Miz-ing link between Myc and p53.Q35008939
Efficient destruction of human immunodeficiency virus in human serum by inhibiting the protective action of complement factor H and decay accelerating factor (DAF, CD55).Q36366046
Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell linesQ37278270
p53-Dependent and -independent responses to cisplatin in mouse testicular teratocarcinoma cellsQ37385633
Adenoviral transduction efficiency of ovarian cancer cells can be limited by loss of integrin beta3 subunit expression and increased by reconstitution of integrin alphavbeta3.Q38303407
Integrin alpha(v)beta1 is an adenovirus coreceptorQ39606281
Human adenovirus serotypes 3 and 5 bind to two different cellular receptors via the fiber head domainQ39869944
A phase I/II trial of rAd/p53 (SCH 58500) gene replacement in recurrent ovarian cancerQ40580007
Intraperitoneal recombinant interferon gamma in ovarian cancer patients with residual disease at second-look laparotomyQ40672850
Defective cytochrome c-dependent caspase activation in ovarian cancer cell lines due to diminished or absent apoptotic protease activating factor-1 activityQ40795999
Analysis of p73 in human borderline and invasive ovarian tumorQ40885719
Effect of p53 status on sensitivity to platinum complexes in a human ovarian cancer cell line.Q40897672
Induced p21waf expression in H1299 cell line promotes cell senescence and protects against cytotoxic effect of radiation and doxorubicinQ40951167
In vivo studies of adenovirus-based p53 gene therapy for ovarian cancerQ41029444
Promoter attenuation in gene therapy: interferon-gamma and tumor necrosis factor-alpha inhibit transgene expressionQ41074143
Genetic mechanisms of tumor suppression by the human p53 geneQ41710706
Adenovirus-mediated wild-type p53 gene transfer in patients receiving chemotherapy for advanced non-small-cell lung cancer: results of a multicenter phase II studyQ43543620
Molecular mechanisms for aberrant expression of the human breast cancer specific gene 1 in breast cancer cells: control of transcription by DNA methylation and intronic sequencesQ43722447
In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirusQ43993914
Determination of molecules regulating gene delivery using adenoviral vectors in ovarian carcinomasQ44270897
Use of transcriptional regulatory elements of the MUC1 and ERBB2 genes to drive tumour-selective expression of a prodrug activating enzymeQ45211397
Intraperitoneal gene therapy with adenoviral-mediated p53 tumor suppressor gene for ovarian cancer model in nude mouseQ45857455
Neutralisation of adenovirus infectivity by ascitic fluid from ovarian cancer patientsQ45867352
Optimizing suicide gene therapy for head and neck cancerQ45884335
p53 Gene therapy for lung cancerQ45886663
Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage III ovarian cancer.Q50512108
Tumour p53 mutations exhibit promoter selective dominance over wild type p53.Q53391608
Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damageQ59098609
P433issue7
P921main subjectovarian cancerQ172341
gene therapyQ213901
P304page(s)415-422
P577publication date2003-07-01
P1433published inLancet Oncology CommissionQ13747613
P1476titleWhy did p53 gene therapy fail in ovarian cancer?
P478volume4

Reverse relations

cites work (P2860)
Q64378710Q64378710
Q40528468A phase I study of Adp53 (INGN 201; ADVEXIN) for patients with platinum- and paclitaxel-resistant epithelial ovarian cancer
Q36419822Adenoviral vectors--how to use them in cancer gene therapy?
Q39065475Adenovirus serotype 11 causes less long-term intraperitoneal inflammation than serotype 5: implications for ovarian cancer therapy
Q36496709Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma
Q43573413Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl
Q33713224Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice
Q92058791Artificially cloaked viral nanovaccine for cancer immunotherapy
Q36226789Cancer-specific gene therapy.
Q34302149Ceramide modulates pre-mRNA splicing to restore the expression of wild-type tumor suppressor p53 in deletion-mutant cancer cells.
Q36695785Characterisation of molecular events following cisplatin treatment of two curable ovarian cancer models: contrasting role for p53 induction and apoptosis in vivo
Q30421664Development of nanoscale approaches for ovarian cancer therapeutics and diagnostics
Q48859616Diffuse encephaloventriculitis and substantial leukoencephalopathy after intraventricular administration of recombinant adenovirus
Q36868494Engineering targeted viral vectors for gene therapy
Q40223019Enriching suicide gene bearing tumor cells for an increased bystander effect
Q34305438Epigenetic therapies as a promising strategy for overcoming chemoresistance in epithelial ovarian cancer
Q35924210Expression and promotor hypermethylation of miR-34a in the various histological subtypes of ovarian cancer.
Q75353680Focus on epithelial ovarian cancer
Q90185529Folate-appended cyclodextrin carrier targets ovarian cancer cells expressing the proton-coupled folate transporter
Q33658229Frequent downregulation of miR-34 family in human ovarian cancers
Q33516121Gene medicine for cancer treatment: commercially available medicine and accumulated clinical data in China
Q36265644Gene therapy imaging in patients for oncological applications.
Q24680275Gene therapy in clinical medicine
Q36922247Gene therapy of gynaecological diseases
Q40309654Gene therapy of ovarian cancer with IFN-alpha-producing fibroblasts: comparison of constitutive and inducible vectors
Q35648549Gene therapy progress and prospects: cancer gene therapy using tumour suppressor genes.
Q36429492Gene therapy vector design strategies for the treatment of cancer
Q36464907Gene transfer approaches for gynecological diseases
Q35596405Gene transfer: Bax to the future for cancer therapy
Q39851900Herpes simplex virus delivery to orthotopic rectal carcinoma results in an efficient and selective antitumor effect.
Q40257577Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis.
Q40002462In vivo restoration of RhoB expression leads to ovarian tumor regression.
Q33205530Infectivity enhanced adenoviral-mediated mda-7/IL-24 gene therapy for ovarian carcinoma
Q64238152Interaction between p53 and Ras signaling controls cisplatin resistance via HDAC4- and HIF-1α-mediated regulation of apoptosis and autophagy
Q36387940Ionizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer
Q44530268Isolated limb perfusion: a novel delivery system for wild-type p53 and fiber-modified oncolytic adenoviruses to extremity sarcoma
Q50130134Long noncoding RNA PANDAR blocks CDKN1A gene transcription by competitive interaction with p53 protein in gastric cancer
Q35694610MET-dependent cancer invasion may be preprogrammed by early alterations of p53-regulated feedforward loop and triggered by stromal cell-derived HGF.
Q64054715Mitochondrially targeted p53 or DBD subdomain is superior to wild type p53 in ovarian cancer cells even with strong dominant negative mutant p53
Q40318210Modification of the p53 transgene of a replication-competent adenovirus prevents mdm2- and E1b-55kD-mediated degradation of p53.
Q37888659Molecular targeted therapy in ovarian cancer: what is on the horizon?
Q64079678Narrowing the field: cancer-specific promoters for mitochondrially-targeted p53-BH3 fusion gene therapy in ovarian cancer
Q37448942Oncolytic adenoviral gene therapy in ovarian cancer: why we are not wasting our time
Q36318189Oncolytic adenoviruses - selective retargeting to tumor cells
Q38450392Oncolytic and immunotherapeutic vaccinia induces antibody-mediated complement-dependent cancer cell lysis in humans
Q37718560OvAd1, a Novel, Potent, and Selective Chimeric Oncolytic Virus Developed for Ovarian Cancer by 3D-Directed Evolution
Q84605146Ovarian cancer
Q34086819Ovarian cancer development and metastasis
Q40361993Ovarian cancer targeted adenoviral-mediated mda-7/IL-24 gene therapy
Q36776863Ovarian cancer treatment with a tumor-targeting and gene expression-controllable lipoplex
Q33748323Ovarian cancer: linking genomics to new target discovery and molecular markers--the way ahead
Q35864258Pharmacological Inhibition of β3 Integrin Reduces the Inflammatory Toxicities Caused by Oncolytic Adenovirus without Compromising Anticancer Activity.
Q37191174Pharmacological activation of p53 in cancer cells
Q93001945Prognosis, Biology, and Targeting of TP53 Dysregulation in Multiple Myeloma
Q35073239Re-engineered p53 activates apoptosis in vivo and causes primary tumor regression in a dominant negative breast cancer xenograft model
Q89389518Recent Progress in Gene Therapy for Ovarian Cancer
Q36710840Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.
Q34627083Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation
Q36713156Results of the 2006 Innsbruck International Consensus Conference on intraperitoneal chemotherapy in patients with ovarian cancer
Q37942529Resuscitating wild-type p53 expression by disrupting ceramide glycosylation: a novel approach to target mutant p53 tumors
Q38187890Revisiting p53 for cancer-specific chemo- and radiotherapy: ten years after
Q33940195Sodium arsenite and hyperthermia modulate cisplatin-DNA damage responses and enhance platinum accumulation in murine metastatic ovarian cancer xenograft after hyperthermic intraperitoneal chemotherapy (HIPEC)
Q34687279Suppression of glucosylceramide synthase restores p53-dependent apoptosis in mutant p53 cancer cells
Q40062926Suppression of human ovarian SKOV-3 cancer cell growth by Duchesnea phenolic fraction is associated with cell cycle arrest and apoptosis
Q34909902Targeted and armed oncolytic poxviruses: a novel multi-mechanistic therapeutic class for cancer
Q36158708Targeted therapy for epithelial ovarian cancer
Q35795073Targeting the p53 signaling pathway in cancer therapy - the promises, challenges and perils
Q61945431Terapia génica: realidades actuales y expectativas
Q38635932The Prognostic 97 Chemoresponse Gene Signature in Ovarian Cancer
Q36180358The effect of adenovirus expressing wild-type p53 on 5-fluorouracil chemosensitivity is related to p53 status in pancreatic cancer cell lines
Q37325095The mitochondrial p53 pathway
Q35986418The tumor suppressor gene TP53: implications for cancer management and therapy
Q35904008The use of gene therapy in cancer research and treatment
Q37803120Translating p53 into the clinic.
Q30465097Translational imaging endpoints to predict treatment response to novel targeted anticancer agents
Q40297448Triple-targeted oncolytic adenoviruses featuring the cox2 promoter, E1A transcomplementation, and serotype chimerism for enhanced selectivity for ovarian cancer cells
Q33820871Upregulation of Coxsackie Adenovirus Receptor Sensitizes Cisplatin-Resistant Lung Cancer Cells to CRAd-Induced Inhibition
Q40036993Virotherapy of ovarian cancer with polymer-cloaked adenovirus retargeted to the epidermal growth factor receptor.
Q37316548Why does cytotoxic chemotherapy cure only some cancers?
Q35180856Wild-type p53 controls cell motility and invasion by dual regulation of MET expression
Q36558001p53 and Nur77/TR3 - transcription factors that directly target mitochondria for cell death induction