Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children

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Copy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children is …
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scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...998269J
P356DOI10.1371/JOURNAL.PONE.0098269
P932PMC publication ID4035277
P698PubMed publication ID24867293
P5875ResearchGate publication ID262694572

P50authorLauren O BakaletzQ78772868
P2093author name stringCharles L Bevins
Edward J Hollox
Anchasa Kananurak
Eric A Jones
P2860cites workOtitis media: prospects for preventionQ37354390
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New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccineQ38363735
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Accurate, high-throughput typing of copy number variation using paralogue ratios from dispersed repeats.Q41838383
Overall cost in the treatment of otitis mediaQ45103023
Measuring the indirect and direct costs of acute otitis mediaQ45116242
Association of higher DEFB4 genomic copy number with Crohn's diseaseQ46779891
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Genomic copy number determines functional expression of {beta}-defensin 2 in airway epithelial cells and associates with chronic obstructive pulmonary disease.Q54433238
Expression of beta-defensins in the tubotympanum of experimental otitis media.Q54586528
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Nasopharyngeal flora in the first three years of life in normal and otitis-prone childrenQ67995129
The nasopharyngeal bacterial flora in children with otitis media with effusionQ71340111
Epidemiologic studies of Streptococcus pneumoniae in infants: acquisition, carriage, and infection during the first 24 months of lifeQ71481021
Use of antibiotics in preventing recurrent acute otitis media and in treating otitis media with effusion. A meta-analytic attempt to resolve the brouhahaQ72325444
Bacterial colonization of the nasopharynx predicts very early onset and persistence of otitis media in Australian aboriginal infantsQ72520625
The prevalence of tympanostomy tubes in children in the United States, 1988Q72824793
Relationship between nasopharyngeal colonization and the development of otitis media in children. Tonawanda/Williamsville PediatricsQ73407663
Risk factors for otitis media with effusion in children 0 to 2 years of ageQ73662728
Genetic polymorphisms in immunoresponse genes TNFA, IL6, IL10, and TLR4 are associated with recurrent acute otitis mediaQ81380920
Analysis of beta-defensin and Toll-like receptor gene copy number variation in celiac diseaseQ84254000
Human β-defensin 2 expression in ELBW infants with severe necrotizing enterocolitisQ84821151
The role of innate immune responses in the outcome of interspecies competition for colonization of mucosal surfacesQ21131627
Burden of disease caused by otitis media: systematic review and global estimatesQ21134594
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colonQ24678661
Antimicrobial activity of innate immune molecules against Streptococcus pneumoniae, Moraxella catarrhalis and nontypeable Haemophilus influenzaeQ24794780
Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cellsQ33346667
Beta-defensin-2 protein is a serum biomarker for disease activity in psoriasis and reaches biologically relevant concentrations in lesional skinQ33415491
Determination of beta-defensin genomic copy number in different populations: A comparison of three methodsQ33833931
Indirect pathogenicity of Haemophilus influenzae and Moraxella catarrhalis in polymicrobial otitis media occurs via interspecies quorum signaling.Q34077467
The microbiologic and immunologic basis for recurrent otitis media in childrenQ34320861
Upper respiratory tract microbial communities, acute otitis media pathogens, and antibiotic use in healthy and sick childrenQ34323552
Measurement methods and accuracy in copy number variation: failure to replicate associations of beta-defensin copy number with Crohn's disease.Q34341147
Clinical practice guideline: Tympanostomy tubes in childrenQ34354895
Association studies of the copy-number variable ß-defensin cluster on 8p23.1 in adenocarcinoma and chronic pancreatitisQ34475611
Epidemiology of otitis media during the first seven years of life in children in greater Boston: a prospective, cohort studyQ34531488
Influenza virus induces bacterial and nonbacterial otitis mediaQ35532832
Streptococcus pneumoniae colonisation: the key to pneumococcal diseaseQ35681330
Genetic susceptibility to otitis mediaQ36005760
Defensins and other antimicrobial peptides: a historical perspective and an updateQ36126577
Viral-bacterial interactions in acute otitis mediaQ36385128
Extracellular DNA within a nontypeable Haemophilus influenzae-induced biofilm binds human beta defensin-3 and reduces its antimicrobial activityQ36807266
Microbial interactions during upper respiratory tract infectionsQ37028479
Allelic recombination between distinct genomic locations generates copy number diversity in human beta-defensins.Q37070555
Host's response in otitis media: understanding genetic susceptibilityQ37251019
Association of nasopharyngeal bacterial colonization during upper respiratory tract infection and the development of acute otitis media.Q37253928
Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzaeQ37340656
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)e98269
P577publication date2014-05-27
P1433published inPLOS OneQ564954
P1476titleCopy number variation of the beta defensin gene cluster on chromosome 8p influences the bacterial microbiota within the nasopharynx of otitis-prone children
P478volume9

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Q35992127The immunology of host defence peptides: beyond antimicrobial activity