Extracellular DNA within a nontypeable Haemophilus influenzae-induced biofilm binds human beta defensin-3 and reduces its antimicrobial activity

scientific article published on 22 August 2012

Extracellular DNA within a nontypeable Haemophilus influenzae-induced biofilm binds human beta defensin-3 and reduces its antimicrobial activity is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1159/000339961
P932PMC publication ID3640559
P698PubMed publication ID22922323

P50authorLauren O BakaletzQ78772868
P2093author name stringGlen McGillivary
Eric A Jones
P2860cites workEnteric defensins are essential regulators of intestinal microbial ecologyQ37483232
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Transforming Growth Factor-β-Smad Signaling Pathway Negatively Regulates Nontypeable Haemophilus influenzae-induced MUC5AC Mucin Transcription via Mitogen-activated Protein Kinase (MAPK) Phosphatase-1-dependent Inhibition of p38 MAPKQ40649602
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Role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear.Q41836976
Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin proteinQ42011049
Nontypeable Haemophilus influenzae initiates formation of neutrophil extracellular trapsQ42165331
Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway.Q43639842
The antimicrobial activity of the cathelicidin LL37 is inhibited by F-actin bundles and restored by gelsolinQ44296193
Overall cost in the treatment of otitis mediaQ45103023
Measuring the indirect and direct costs of acute otitis mediaQ45116242
Nontypeable Haemophilus influenzae lipoprotein P6 induces MUC5AC mucin transcription via TLR2-TAK1-dependent p38 MAPK-AP1 and IKKbeta-IkappaBalpha-NF-kappaB signaling pathwaysQ46058384
Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteinsQ46927233
Release of the antimicrobial peptide LL-37 from DNA/F-actin bundles in cystic fibrosis sputum.Q51084969
Capsule polysaccharide is a bacterial decoy for antimicrobial peptides.Q54413052
Multiple combination antibiotic susceptibility testing of nontypeable Haemophilus influenzae biofilmsQ59510334
The non-typeable Haemophilus influenzae Sap transporter provides a mechanism of antimicrobial peptide resistance and SapD-dependent potassium acquisitionQ79299836
Differential expression of human beta defensin 2 and human beta defensin 3 in human middle ear cholesteatomaQ80123581
Hydrophobic interactions in complexes of antimicrobial peptides with bacterial polysaccharidesQ80505630
Abrogation of nontypeable Haemophilus influenzae protein D function reduces phosphorylcholine decoration, adherence to airway epithelial cells, and fitness in a chinchilla model of otitis mediaQ82939703
Extracellular DNA chelates cations and induces antibiotic resistance in Pseudomonas aeruginosa biofilmsQ21090518
Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6Q22010648
Antimicrobial polypeptides in host defense of the respiratory tractQ24551612
Biofilm formation by nontypeable Haemophilus influenzae: strain variability, outer membrane antigen expression and role of piliQ24793297
Bacterial biofilms: a common cause of persistent infectionsQ27861033
Defensins: antimicrobial peptides of innate immunityQ28204453
The biofilm matrixQ29547334
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptideQ29619485
Compared to placebo, long-term antibiotics resolve otitis media with effusion (OME) and prevent acute otitis media with perforation (AOMwiP) in a high-risk population: a randomized controlled trialQ30482567
Direct detection of bacterial biofilms on the middle-ear mucosa of children with chronic otitis mediaQ33249853
A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis mediaQ33557688
Differential and coordinated expression of defensins and cytokines by gingival epithelial cells and dendritic cells in response to oral bacteriaQ33629441
Demonstration of Type IV pilus expression and a twitching phenotype by Haemophilus influenzaeQ33716078
The multifunctional host defense peptide SPLUNC1 is critical for homeostasis of the mammalian upper airwayQ33719376
Pilus-mediated adherence of Haemophilus influenzae to human respiratory mucinsQ34004701
Nontypeable Haemophilus influenzae: pathogenesis and preventionQ34009998
Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modalityQ34162570
The human beta-defensin-3, an antibacterial peptide with multiple biological functionsQ34566449
Escherichia coli competence gene homologs are essential for competitive fitness and the use of DNA as a nutrientQ34697000
Heme utilization by nontypeable Haemophilus influenzae is essential and dependent on Sap transporter functionQ35096143
Cryptococcus neoformans cells in biofilms are less susceptible than planktonic cells to antimicrobial molecules produced by the innate immune systemQ35217511
Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era.Q35530691
Quorum sensing and DNA release in bacterial biofilmsQ36418307
Production of beta-defensins by human airway epitheliaQ36758628
Nontypeable Haemophilus influenzae: understanding virulence and commensal behaviorQ36864761
Evidence behind the WHO guidelines: hospital care for children: what is the most effective antibiotic regime for chronic suppurative otitis media in children?Q37178849
Salivary mucins inhibit antibacterial activity of the cathelicidin-derived LL-37 peptide but not the cationic steroid CSA-13.Q37324151
Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzaeQ37340656
P433issue1
P921main subjectbiofilmQ467410
Haemophilus influenzaeQ1141979
P304page(s)24-38
P577publication date2012-08-22
P1433published inJournal of Innate ImmunityQ15817533
P1476titleExtracellular DNA within a nontypeable Haemophilus influenzae-induced biofilm binds human beta defensin-3 and reduces its antimicrobial activity
P478volume5

Reverse relations

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