Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes

scientific article

Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2014PLoSO...998893N
P356DOI10.1371/JOURNAL.PONE.0098893
P932PMC publication ID4044035
P698PubMed publication ID24892553
P5875ResearchGate publication ID262817459

P2093author name stringAli El-Armouche
Thomas Eschenhagen
Christiane Neuber
Hannieh Sotoud
June Uebeler
Thomas Schulze
P2860cites workCoupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1Q22011167
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsQ24298956
The unfolded protein response signals through high-order assembly of Ire1Q27653139
Signal integration in the endoplasmic reticulum unfolded protein responseQ27860577
Perk is essential for translational regulation and cell survival during the unfolded protein responseQ28140062
Evidence for protein phosphatase inhibitor-1 playing an amplifier role in beta-adrenergic signaling in cardiac myocytesQ28201819
Translational control is required for the unfolded protein response and in vivo glucose homeostasisQ28204066
Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosisQ28275274
Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac functionQ28287075
Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinaseQ28296183
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stressQ28306995
Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prionsQ28472560
Feedback inhibition of the unfolded protein response by GADD34-mediated dephosphorylation of eIF2alphaQ28512201
Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alphaQ28572217
A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell deathQ28576403
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosisQ28576685
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunitiesQ29617768
A trip to the ER: coping with stressQ29620455
Imidazoline-guanidinium and α2-adrenergic binding sites in basolateral membranes from human kidneyQ68243765
Clonidine binds to imidazole binding sites as well as alpha 2-adrenoceptors in the ventrolateral medullaQ70170115
α1-antagonist activity of the α2-adrenoceptor agonist guanabenz in perfused mesenteric artery of the ratQ72393144
Cardioprotective effect of 3-iodothyronamine in perfused rat heart subjected to ischemia and reperfusionQ84590429
Human and mouse trace amine-associated receptor 1 have distinct pharmacology towards endogenous monoamines and imidazoline receptor ligandsQ33499502
Cardiomyocyte death in doxorubicin-induced cardiotoxicityQ33604134
Selective inhibition of a regulatory subunit of protein phosphatase 1 restores proteostasisQ34169287
Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophyQ34605368
Guanabenz. A review of its pharmacodynamic properties and therapeutic efficacy in hypertensionQ34708663
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodelingQ34792858
Inhibition of monoamine oxidase A and B activities by imidazol(ine)/guanidine drugs, nature of the interaction and distinction from I2-imidazoline receptors in rat liverQ35026368
The ASK1-MAP kinase cascades in mammalian stress responseQ35983902
Endoplasmic reticulum stress in disease pathogenesisQ36842308
How IRE1 reacts to ER stressQ37055568
Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian developmentQ37100863
Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cellsQ37388595
ER stress in cardiovascular diseaseQ37632850
What is the role of ER stress in the heart? Introduction and series overviewQ37771143
Endoplasmic reticulum stress as a therapeutic target in cardiovascular diseaseQ37804650
Exploiting the selectivity of protein phosphatase 1 for pharmacological interventionQ37984815
Ablation of C/EBP homologous protein attenuates endoplasmic reticulum-mediated apoptosis and cardiac dysfunction induced by pressure overloadQ38342543
Thapsigargin triggers cardiac contractile dysfunction via NADPH oxidase-mediated mitochondrial dysfunction: Role of Akt dephosphorylationQ39376773
Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1.Q39917756
Guanabenz, an alpha2-selective adrenergic agonist, activates Ca2+-dependent chloride currents in cystic fibrosis human airway epithelial cellsQ39959384
Modulation of cardiac ionic homeostasis by 3-iodothyronamine.Q42042391
Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stressQ42163338
Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinaseQ42833009
Development of a drug screening platform based on engineered heart tissueQ43071445
Hypoxic reactive oxygen species regulate the integrated stress response and cell survival.Q43248372
Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophyQ46438826
Cardiac effects of trace amines: pharmacological characterization of trace amine-associated receptorsQ46590883
A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stressQ46709446
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectguanabenzQ5613542
P304page(s)e98893
P577publication date2014-06-03
P1433published inPLOS OneQ564954
P1476titleGuanabenz interferes with ER stress and exerts protective effects in cardiac myocytes
P478volume9

Reverse relations

cites work (P2860)
Q52371362Adult mouse eIF2Bε Arg191His astrocytes display a normal integrated stress response in vitro.
Q35856564Autism-associated R451C mutation in neuroligin3 leads to activation of the unfolded protein response in a PC12 Tet-On inducible system
Q26776182Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases
Q33790629Guanabenz Prevents d-Galactosamine/Lipopolysaccharide-Induced Liver Damage and Mortality
Q35751278Lycopene Protects against Hypoxia/Reoxygenation Injury by Alleviating ER Stress Induced Apoptosis in Neonatal Mouse Cardiomyocytes
Q61801081Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson's disease
Q93178356N-acetyl-seryl-aspartyl-lysyl-proline treatment protects heart against excessive myocardial injury and heart failure in mice
Q88111665ROS signaling and ER stress in cardiovascular disease
Q38820202Role of protein phosphatase inhibitor-1 in cardiac beta adrenergic pathway

Search more.