R-spondin 3 regulates dorsoventral and anteroposterior patterning by antagonizing Wnt/β-catenin signaling in zebrafish embryos

scientific article

R-spondin 3 regulates dorsoventral and anteroposterior patterning by antagonizing Wnt/β-catenin signaling in zebrafish embryos is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2014PLoSO...999514R
P356DOI10.1371/JOURNAL.PONE.0099514
P932PMC publication ID4053527
P698PubMed publication ID24918770
P5875ResearchGate publication ID263014263

P2093author name stringChen Chen
Yun Li
Jianfeng Zhou
Ling Lu
Yumei Zhou
Cunming Duan
Yunzhang Liu
Pin Zhou
Xiaozhi Rong
P2860cites workA direct role for Wnt8 in ventrolateral mesoderm patterningQ51899753
Maternally controlled (beta)-catenin-mediated signaling is required for organizer formation in the zebrafish.Q52165854
Function of zebrafish beta-catenin and TCF-3 in dorsoventral patterningQ52182998
The zebrafish organizer requires chordinoQ59051482
Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plateQ73109226
Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote MorphogenesisQ83598918
Stem cells: Orphan receptors find a homeQ84784442
R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5Q21560784
R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6Q24292884
R-spondins function as ligands of the orphan receptors LGR4 and LGR5 to regulate Wnt/beta-catenin signalingQ24307371
Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expressionQ24308067
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signallingQ24310750
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive mannerQ24320153
Interaction with both ZNRF3 and LGR4 is required for the signalling activity of R-spondinQ24338954
A molecular mechanism for the effect of lithium on developmentQ24629067
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
The R-spondin protein familyQ27021525
Cellular signaling and biological functions of R-spondinsQ27023891
Stages of embryonic development of the zebrafishQ27860947
The Wnt signaling pathway in development and diseaseQ27861019
Beta-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryosQ28292382
A role for MKP3 in axial patterning of the zebrafish embryoQ28312209
The Wnt signaling regulator R-spondin 3 promotes angioblast and vascular developmentQ28511252
R-spondin3 is required for mouse placental developmentQ28512828
Dickkopf-1 is a member of a new family of secreted proteins and functions in head inductionQ29616164
Identification and mechanism of regulation of the zebrafish dorsal determinantQ30430577
Regulation of dharma/bozozok by the Wnt pathwayQ30657188
R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesisQ34356591
The Stress-Response Gene redd1 Regulates Dorsoventral Patterning by Antagonizing Wnt/β-catenin Activity in ZebrafishQ34541021
Molecular genetics of axis formation in zebrafishQ34562575
Wnt-5/pipetail functions in vertebrate axis formation as a negative regulator of Wnt/beta-catenin activity.Q36323273
Wnt Signaling in Vertebrate Axis SpecificationQ36629761
R-Spondin family members regulate the Wnt pathway by a common mechanismQ36678039
Maternal and zygotic control of zebrafish dorsoventral axial patterningQ37937575
Wnt/beta-catenin regulation of the Sp1-related transcription factor sp5l promotes tail development in zebrafish.Q38514802
Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements.Q38520593
Zebrafish wnt8 encodes two wnt8 proteins on a bicistronic transcript and is required for mesoderm and neurectoderm patterning.Q38523908
Zebrafishwnt8andwnt8bshare a common activity but are involved in distinct developmental pathwaysQ38531729
Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of XenopusQ38533172
LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.Q38611943
RSPO2-LGR5 signaling has tumour-suppressive activity in colorectal cancer.Q39029239
Waif1/5T4 inhibits Wnt/β-catenin signaling and activates noncanonical Wnt pathways by modifying LRP6 subcellular localization.Q39440406
A novel homeobox gene, dharma, can induce the organizer in a non-cell-autonomous manner.Q40445343
Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF.Q40464061
Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizerQ41842388
A finger on the pulse of Wnt receptor signalingQ42532344
Essential and opposing roles of zebrafish beta-catenins in the formation of dorsal axial structures and neurectodermQ42681585
Dickkopf-1 regulates gastrulation movements by coordinated modulation of Wnt/beta catenin and Wnt/PCP activities, through interaction with the Dally-like homolog KnypekQ42856607
Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo.Q43744674
Structure, developmental expression, and physiological regulation of zebrafish IGF binding protein-1.Q44645156
Interaction of Wnt and caudal-related genes in zebrafish posterior body formationQ45263246
Fgf signalling controls the dorsoventral patterning of the zebrafish embryoQ47073185
Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesisQ47073664
Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formationQ47073690
Genetic evidence for involvement of maternally derived Wnt canonical signaling in dorsal determination in zebrafishQ47074026
WNT8 and BMP2B co-regulate non-axial mesoderm patterning during zebrafish gastrulationQ47074067
Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish.Q47074221
Zebrafish organizer development and germ-layer formation require nodal-related signalsQ48021535
Frzb, a secreted protein expressed in the Spemann organizer, binds and inhibits Wnt-8.Q48052411
R-spondin1 is a high affinity ligand for LRP6 and induces LRP6 phosphorylation and beta-catenin signalingQ50336904
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectDanio rerioQ169444
R-spondin 3Q29829893
P304page(s)e99514
P577publication date2014-06-11
P1433published inPLOS OneQ564954
P1476titleR-spondin 3 regulates dorsoventral and anteroposterior patterning by antagonizing Wnt/β-catenin signaling in zebrafish embryos
P478volume9

Reverse relations

cites work (P2860)
Q36624568An oxygen-insensitive Hif-3α isoform inhibits Wnt signaling by destabilizing the nuclear β-catenin complex.
Q42697679Characterization and expression pattern of r-spondin1 in Cynoglossus semilaevis
Q89388867Cynoglossus semilaevis Rspo3 Regulates Embryo Development by Inhibiting the Wnt/β-Catenin Signaling Pathway
Q36311447Glutathione peroxidase 4 inhibits Wnt/β-catenin signaling and regulates dorsal organizer formation in zebrafish embryos.
Q90447993R-spondin family members as novel biomarkers and prognostic factors in lung cancer
Q96131758RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
Q37224290Systemic chromosome instability in Shugoshin-1 mice resulted in compromised glutathione pathway, activation of Wnt signaling and defects in immune system in the lung
Q58711111The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation

Search more.