Thermally induced osteocyte damage initiates a remodelling signaling cascade.

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Thermally induced osteocyte damage initiates a remodelling signaling cascade. is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1019652D
P356DOI10.1371/JOURNAL.PONE.0119652
P932PMC publication ID4364670
P698PubMed publication ID25785846
P5875ResearchGate publication ID273784072

P50authorEimear DolanQ59490130
Laoise McNamaraQ21264241
P2093author name stringMatthew G Haugh
David Tallon
Muriel C Voisin
P2860cites workLoss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivoQ50514494
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Thermally induced bone necrosis in rabbits. Relation to implant failure in humansQ71351145
Thermal injury to bone. A vital-microscopic description of heat effectsQ71614963
Modeled microgravity stimulates osteoclastogenesis and bone resorption by increasing osteoblast RANKL/OPG ratioQ80155665
Osteogenic differentiation of mesenchymal stem cells is regulated by osteocyte and osteoblast cells in a simplified bone nicheQ83224587
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A role for the primary cilium in paracrine signaling between mechanically stimulated osteocytes and mesenchymal stem cellsQ38254472
Heat and bone tissue. An experimental investigation of the thermal properties of bone and threshold levels for thermal injuryQ38706855
BMP9 and COX-2 form an important regulatory loop in BMP9-induced osteogenic differentiation of mesenchymal stem cellsQ39104311
Treatment of bone tumours by radiofrequency thermal ablationQ39303152
RANKL and OPG activity is regulated by injury size in networks of osteocyte-like cellsQ39653747
Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localized bone destructionQ39988553
Mechanically stimulated osteocytes regulate osteoblastic activity via gap junctionsQ40248461
Heat shock-induced enhancement of osteoblastic differentiation of hTERT-immortalized mesenchymal stem cellsQ40262425
Conditioned medium from osteocytes stimulates the proliferation of bone marrow mesenchymal stem cells and their differentiation into osteoblastsQ40578199
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Mild heat shock induces proliferation, alkaline phosphatase activity, and mineralization in human bone marrow stromal cells and Mg-63 cells in vitroQ42503243
Osteocyte differentiation is regulated by extracellular matrix stiffness and intercellular separationQ42814254
Tyrosines 559 and 807 in the cytoplasmic tail of the macrophage colony-stimulating factor receptor play distinct roles in osteoclast differentiation and functionQ44226046
Thermotherapy using magnetic cationic liposomes powerfully suppresses prostate cancer bone metastasis in a novel rat modelQ44486633
Adult stem cells from bone marrow (MSCs) isolated from different strains of inbred mice vary in surface epitopes, rates of proliferation, and differentiation potentialQ45869862
How bone tissue and cells experience elevated temperatures during orthopaedic cutting: an experimental and computational investigationQ46286331
Osteoprotegerin: a novel secreted protein involved in the regulation of bone densityQ24313918
The amazing osteocyteQ24635849
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
Osteocytes: master orchestrators of boneQ27022407
Osteoclast differentiation and activationQ29547556
Establishment and characterization of an osteocyte-like cell line, MLO-Y4.Q33543103
Osteocyte apoptosis is required for production of osteoclastogenic signals following bone fatigue in vivo.Q33803842
Functional gap junctions between osteocytic and osteoblastic cellsQ33892357
Minireview: the OPG/RANKL/RANK systemQ34102256
Morphological evidence of gap junctions between bone cellsQ34269927
E11/gp38 selective expression in osteocytes: regulation by mechanical strain and role in dendrite elongationQ34718158
Investigation of the optimal timing for chondrogenic priming of MSCs to enhance osteogenic differentiation in vitro as a bone tissue engineering strategy.Q34901255
Bone microdamage and cell apoptosisQ35622532
The influence of mechanical stimulation on osteocyte apoptosis and bone viability in human trabecular bone.Q35741137
Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysisQ35843398
Osteocyte signaling in boneQ36005495
Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populationsQ36005508
Heat-shock-induced cellular responses to temperature elevations occurring during orthopaedic cutting.Q36348524
Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and AblQ36365371
Functions of RANKL/RANK/OPG in bone modeling and remodelingQ36700779
The biology of osteocytesQ36830313
Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loadingQ36973979
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)e0119652
P577publication date2015-03-18
P1433published inPLOS OneQ564954
P1476titleThermally induced osteocyte damage initiates a remodelling signaling cascade
P478volume10

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cites work (P2860)
Q47372646A Comparative Assessment of Implant Site Viability in Humans and Rats
Q38559011Bone Homeostasis and Repair: Forced Into Shape.
Q41956984Pelleted Bone Marrow Derived Mesenchymal Stem Cells Are Better Protected from the Deleterious Effects of Arthroscopic Heat Shock
Q37078423Thermally induced osteocyte damage initiates pro-osteoclastogenic gene expression in vivo

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