Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex

scientific article

Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2014PLoSO...9j5933M
P356DOI10.1371/JOURNAL.PONE.0105933
P932PMC publication ID4146563
P698PubMed publication ID25162227
P5875ResearchGate publication ID265134947

P50authorKay DaviesQ6380176
Tom LickissQ57903314
Mattéa J FinelliQ59684553
Zoltán MolnárQ41787890
P2093author name stringSheena Lee
Justin M Moore
Peter L Oliver
P2860cites workAF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)Q22010909
Interaction between LIS1 and doublecortin, two lissencephaly gene productsQ24290295
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOFQ24305335
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion productQ24310468
Triangular tibia with fibular aplasia associated with a microdeletion on 2q11.2 encompassing LAF4Q24311907
LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemiasQ24316133
Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG islandQ24324761
BRCA1 is a component of the RNA polymerase II holoenzymeQ24675704
MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse developmentQ26269867
The AFF4 scaffold binds human P-TEFb adjacent to HIV TatQ27676733
Loss of FMR2 further emphasizes the link between deregulation of immediate early response genes FOS and JUN and intellectual disabilityQ28116032
Altered lymphoid development in mice deficient for the mAF4 proto-oncogeneQ73971545
Identification of the novel AML1 fusion partner gene, LAF4, a fusion partner of MLL, in childhood T-cell acute lymphoblastic leukemia with t(2;21)(q11;q22) by bubble PCR method for cDNAQ81516051
The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodelingQ40202913
New insights to the MLL recombinome of acute leukemiasQ44945193
Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility geneQ45138440
A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse.Q48256073
The mouse Laf4 gene: exon/intron organization, cDNA sequence, alternative splicing, and expression during central nervous system development.Q48571316
Examining the relationship between early axon growth and transcription factor expression in the developing cerebral cortexQ48733418
Cognitive, behavioral, and neuroanatomical assessment of two unrelated male children expressing FRAXE.Q48797273
Expression of Leukaemia associated transcription factor Af9/Mllt3 in the cerebral cortex of the mouseQ48832169
The MDGA1 gene confers risk to schizophrenia and bipolar disorderQ48949086
c-Jun N-terminal kinase phosphorylation of MARCKSL1 determines actin stability and migration in neurons and in cancer cellsQ28270073
Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticismQ28292730
Misguided transcriptional elongation causes mixed lineage leukemiaQ28471927
Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemiaQ28513902
RNAi reveals doublecortin is required for radial migration in rat neocortexQ28567912
Dual subcellular roles for LIS1 and dynein in radial neuronal migration in live brain tissueQ28569828
Interaction between autism-linked MDGAs and neuroligins suppresses inhibitory synapse developmentQ28571273
Radial migration of superficial layer cortical neurons controlled by novel Ig cell adhesion molecule MDGA1Q28584932
IgSF molecule MDGA1 is involved in radial migration and positioning of a subset of cortical upper-layer neuronsQ28585324
Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out miceQ28586975
Neuronal subtype specification in the cerebral cortexQ29616190
Increased LIS1 expression affects human and mouse brain developmentQ30639738
Fusion of an AF4-related gene, LAF4, to MLL in childhood acute lymphoblastic leukemia with t(2;11)(q11;q23)Q30792869
Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genesQ33474877
AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development.Q33518246
Characterisation and expression of a large, 13.7 kb FMR2 isoformQ33858233
Heterogeneity in ventricular zone neural precursors contributes to neuronal fate diversity in the postnatal neocortex.Q34019012
Functional characterization of the AFF (AF4/FMR2) family of RNA-binding proteins: insights into the molecular pathology of FRAXE intellectual disabilityQ34025778
Lissencephaly. A human brain malformation associated with deletion of the LIS1 gene located at chromosome 17p13.Q34059516
LAF4, an AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemiaQ34146868
LAF-4 is aberrantly expressed in human breast cancerQ34392980
Gene structure and subcellular localization of FMR2, a member of a new family of putative transcription activatorsQ34439319
Expression of the murine homologue of FMR2 in mouse brain and during developmentQ34456606
Clinical and molecular basis of classical lissencephaly: Mutations in the LIS1 gene (PAFAH1B1).Q34468937
Rostral growth of commissural axons requires the cell adhesion molecule MDGA2.Q35040124
FRA2A is a CGG repeat expansion associated with silencing of AFF3Q35156954
Function of leukemogenic mixed lineage leukemia 1 (MLL) fusion proteins through distinct partner protein complexesQ35229311
FMR2 function: insight from a mouse knockout modelQ35550087
Triplet repeat expansion at the FRAXE locus and X-linked mild mental handicap.Q35889234
The robotic mouse: unravelling the function of AF4 in the cerebellumQ36328456
A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modificationQ36447915
H3K79 methylation profiles define murine and human MLL-AF4 leukemiasQ36991857
Mediation of Af4 protein function in the cerebellum by Siah proteinsQ37570724
Regulation of the development of tectal neurons and their projections by transcription factors Brn3a and Pax7.Q38619768
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
ImageQuantQ112270642
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectdisabilityQ12131
intellectual disabilityQ183560
cell migrationQ189092
disability affecting intellectual abilitiesQ3317827
AF4/FMR2 family, member 3Q21496854
MAM domain containing glycosylphosphatidylinositol anchor 2Q21986124
P304page(s)e105933
P577publication date2014-08-27
P1433published inPLOS OneQ564954
P1476titleLaf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex
P478volume9

Reverse relations

cites work (P2860)
Q37393891A sequence variant associating with educational attainment also affects childhood cognition
Q35905777Combined transcriptome studies identify AFF3 as a mediator of the oncogenic effects of β-catenin in adrenocortical carcinoma
Q92461031De novo AFF3 variant in a patient with mesomelic dysplasia with foot malformation
Q37417813FoxO6 affects Plxna4-mediated neuronal migration during mouse cortical development.
Q90442613Genes regulated by SATB2 during neurodevelopment contribute to schizophrenia and educational attainment
Q92352998Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis
Q26770788Molecular Pathways Underlying Projection Neuron Production and Migration during Cerebral Cortical Development
Q64067342Systematic characterization of germline variants from the DiscovEHR study endometrial carcinoma population
Q47904811Using Human iPSC-Derived Neurons to Uncover Activity-Dependent Non-Coding RNAs.

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