Mediation of Af4 protein function in the cerebellum by Siah proteins

scholarly article

Mediation of Af4 protein function in the cerebellum by Siah proteins is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2004PNAS..10114901O
P356DOI10.1073/PNAS.0406196101
P932PMC publication ID522018
P698PubMed publication ID15459319
P5875ResearchGate publication ID8256845

P50authorKay DaviesQ6380176
P2093author name stringEmmanuelle Bitoun
Emma L Jones
Joanne Clark
Peter L Oliver
P2860cites workAF5q31, a newly identified AF4-related gene, is fused to MLL in infant acute lymphoblastic leukemia with ins(5;11)(q31;q13q23)Q22010909
Siah-1 facilitates ubiquitination and degradation of synphilin-1Q24295130
Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion productQ24310468
LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemiasQ24316133
Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathwayQ24318831
Identification of FMR2, a novel gene associated with the FRAXE CCG repeat and CpG islandQ24324761
p53-inducible human homologue of Drosophila seven in absentia (Siah) inhibits cell growth: suppression by BAG-1.Q24533238
Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteinsQ24554569
Siah ubiquitin ligase is structurally related to TRAF and modulates TNF-alpha signalingQ27636810
A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiationQ28115658
Themes and variations on ubiquitylationQ28206411
Regulation of synaptophysin degradation by mammalian homologues of seven in absentiaQ28215219
Exon/intron structure of the human AF-4 gene, a member of the AF-4/LAF-4/FMR-2 gene family coding for a nuclear protein with structural alterations in acute leukaemiaQ28244456
Interaction of AF4 wild-type and AF4.MLL fusion protein with SIAH proteins: indication for t(4;11) pathobiology?Q28268824
Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out miceQ28586975
Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemiaQ33652400
Characterisation and expression of a large, 13.7 kb FMR2 isoformQ33858233
p53 suppresses the c-Myb-induced activation of heat shock transcription factor 3.Q33896669
Insights from mouse models into the molecular basis of neurodegenerationQ33938799
Fragile XE-associated familial mental retardation protein 2 (FMR2) acts as a potent transcription activatorQ33946912
Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologueQ34134107
Identification of the gene FMR2, associated with FRAXE mental retardationQ34385889
Gene structure and subcellular localization of FMR2, a member of a new family of putative transcription activatorsQ34439319
Expression of the murine homologue of FMR2 in mouse brain and during developmentQ34456606
Seven in absentia homolog 1A mediates ubiquitination and degradation of group 1 metabotropic glutamate receptorsQ34513871
A binding motif for Siah ubiquitin ligase.Q34866593
Mouse Models of Human CAG Repeat DisordersQ41527091
Neurodegeneration in Lurcher mice caused by mutation in delta2 glutamate receptor geneQ48045866
A mutation in Af4 is predicted to cause cerebellar ataxia and cataracts in the robotic mouse.Q48256073
Isolation and characterisation of murine homologues of the Drosophila seven in absentia gene (sina).Q52545500
Altered lymphoid development in mice deficient for the mAF4 proto-oncogeneQ73971545
P433issue41
P407language of work or nameEnglishQ1860
P304page(s)14901-14906
P577publication date2004-09-30
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleMediation of Af4 protein function in the cerebellum by Siah proteins
P478volume101

Reverse relations

cites work (P2860)
Q33518246AF4 is a critical regulator of the IGF-1 signaling pathway during Purkinje cell development.
Q84383056Animal models of human cerebellar ataxias: a cornerstone for the therapies of the twenty-first century
Q33285195Comparative genetic analysis: the utility of mouse genetic systems for studying human monogenic disease
Q90167898DBC1, p300, HDAC3, and Siah1 coordinately regulate ELL stability and function for expression of its target genes
Q28076446Disorders of Transcriptional Regulation: An Emerging Category of Multiple Malformation Syndromes
Q35236310Germline gain-of-function mutations in AFF4 cause a developmental syndrome functionally linking the super elongation complex and cohesin
Q28513902Infertility with defective spermiogenesis in mice lacking AF5q31, the target of chromosomal translocation in human infant leukemia
Q35232809Laf4/Aff3, a gene involved in intellectual disability, is required for cellular migration in the mouse cerebral cortex
Q33383191Mecp2-null mice provide new neuronal targets for Rett syndrome.
Q38161393Molecular and Epigenetic Mechanisms of MLL in Human Leukemogenesis
Q30463349New insights into behaviour using mouse ENU mutagenesis
Q33901300Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms.
Q28590290Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia
Q40147483Siah-1S, a novel splice variant of Siah-1 (seven in absentia homolog), counteracts Siah-1-mediated downregulation of beta-catenin
Q24313326Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex
Q41352951TBP loading by AF4 through SL1 is the major rate-limiting step in MLL fusion-dependent transcription
Q40202913The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling
Q37429914The robotic mouse: understanding the role of AF4, a cofactor of transcriptional elongation and chromatin remodelling, in purkinje cell function
Q36328456The robotic mouse: unravelling the function of AF4 in the cerebellum
Q35990164The ubiquitin ligase Siah1 controls ELL2 stability and formation of super elongation complexes to modulate gene transcription
Q33813039The ubiquitin ligase Siah2 and the hypoxia response

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