P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition

scientific article

P21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BBAMCR.2015.02.023
P8608Fatcat IDrelease_qer7oeqfj5a3tlub3s5mwpcuqq
P932PMC publication ID4380670
P698PubMed publication ID25746720
P5875ResearchGate publication ID273326905

P2093author name stringFei Gao
Payaningal R Somanath
Ahmad Al-Azayzih
P2860cites workTransforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3Q24550794
The role of Snail in prostate cancerQ27004557
Epithelial-mesenchymal transitions in development and diseaseQ27860630
Mechanisms of TGF-beta signaling from cell membrane to the nucleusQ27860785
Cancer statistics, 2014Q27861018
Cadherins and epithelial-to-mesenchymal transitionQ38088483
TGFβ and matrix-regulated epithelial to mesenchymal transitionQ38190340
P21 activated kinases: structure, regulation, and functionsQ38198494
The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4.Q38994899
TRAF4 promotes TGF-β receptor signaling and drives breast cancer metastasisQ39105929
An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently.Q39805071
Transforming growth factor beta1 induces apoptosis by suppressing FLICE-like inhibitory protein in DU145 prostate epithelial cellsQ39910058
PAK1 regulates myosin II-B phosphorylation, filament assembly, localization and cell chemotaxisQ40402760
Mechanism of p21-activated Kinase 6-mediated Inhibition of Androgen Receptor SignalingQ40624022
Rac, PAK and p38 regulate cell contact-dependent nuclear translocation of myocardin-related transcription factor.Q41286123
Tumor measurement in the nude mouseQ41355093
Rac1/PAK1 signaling promotes epithelial-mesenchymal transition of podocytes in vitro via triggering β-catenin transcriptional activity under high glucose conditionsQ45072545
Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinomaQ60549518
Androgen receptor specifically interacts with a novel p21-activated kinase, PAK6Q28208123
NEDD9 crucially regulates TGF-β-triggered epithelial-mesenchymal transition and cell invasion in prostate cancer cells: involvement in cancer progressivenessQ28238097
p21-Activated kinase 4 promotes prostate cancer progression through CREBQ28269126
PAK1 kinase promotes cell motility and invasiveness through CRK-II serine phosphorylation in non-small cell lung cancer cellsQ28272164
TGFβ signalling in contextQ28275410
A PAK4-LIMK1 pathway drives prostate cancer cell migration downstream of HGFQ28277064
P21 activated kinase-1 (Pak1) promotes prostate tumor growth and microinvasion via inhibition of transforming growth factor β expression and enhanced matrix metalloproteinase 9 secretionQ28281866
TGFbeta in CancerQ28288866
PAK signalling during the development and progression of cancerQ28307460
Rac1 activation driven by 14-3-3ζ dimerization promotes prostate cancer cell-matrix interactions, motility and transendothelial migrationQ28481314
FLICE-like inhibitory protein blocks transforming growth factor beta 1-induced caspase activation and apoptosis in prostate epithelial cellsQ28572067
Cancer metastasis: building a frameworkQ29616783
Epithelial-to-mesenchymal transition in prostate cancer: paradigm or puzzle?Q33351622
Two faces of TGF-beta1 in breast cancerQ33661529
SMAD3 represses androgen receptor-mediated transcriptionQ33940789
TGFβ-induced invasion of prostate cancer cells is promoted by c-Jun-dependent transcriptional activation of Snail1Q34028544
Clinically relevant doses of candesartan inhibit growth of prostate tumor xenografts in vivo through modulation of tumor angiogenesisQ34125083
DHT Selectively Reverses Smad3-Mediated/TGF-β-Induced Responses through Transcriptional Down-Regulation of Smad3 in Prostate Epithelial CellsQ34197256
TGF-beta signaling in cancer--a double-edged swordQ34421804
Non-Smad TGF-beta signalsQ34443708
European cancer mortality predictions for the year 2014.Q34661464
PAK1 as a therapeutic targetQ35108164
BRAF and RAS oncogenes regulate Rho GTPase pathways to mediate migration and invasion properties in human colon cancer cells: a comparative studyQ35299011
TGFβ1 induces apoptosis in invasive prostate cancer and bladder cancer cells via Akt-independent, p38 MAPK and JNK/SAPK-mediated activation of caspasesQ36792632
Vimentin and epithelial-mesenchymal transition in human breast cancer--observations in vitro and in vivo.Q36857862
Pak1 kinase links ErbB2 to β-catenin in transformation of breast epithelial cellsQ36941519
PAK1 regulates breast cancer cell invasion through secretion of matrix metalloproteinases in response to prolactin and three-dimensional collagen IV.Q36998060
14-3-3beta-Rac1-p21 activated kinase signaling regulates Akt1-mediated cytoskeletal organization, lamellipodia formation and fibronectin matrix assemblyQ37013219
The relevance of the TGF-β Paradox to EMT-MET programsQ37118399
Tumor necrosis factor-receptor-associated factor-4 is a positive regulator of transforming growth factor-beta signaling that affects neural crest formationQ37262166
Dysfunctional transforming growth factor-beta receptor II accelerates prostate tumorigenesis in the TRAMP mouse modelQ37355355
TGF-β: duality of function between tumor prevention and carcinogenesis.Q37634488
Switching TGFβ from a tumor suppressor to a tumor promoter.Q37830876
Non-Smad signaling pathwaysQ37893980
TGF-β signaling and epithelial-mesenchymal transition in cancer progressionQ38063807
P4510describes a project that usesImageJQ1659584
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectprostate cancerQ181257
P304page(s)1229-1239
P577publication date2015-03-06
P1433published inBiochimica et Biophysica ActaQ864239
P1476titleP21 activated kinase-1 mediates transforming growth factor β1-induced prostate cancer cell epithelial to mesenchymal transition
P478volume1853

Reverse relations

cites work (P2860)
Q41637016Akt1 promotes stimuli-induced endothelial-barrier protection through FoxO-mediated tight-junction protein turnover
Q42086463Clinicopathological signature of p21-activated kinase 1 in prostate cancer and its regulation of proliferation and autophagy via the mTOR signaling pathway
Q89939464DEP Domain-Containing Protein 1B (DEPDC1B) Promotes Migration and Invasion in Pancreatic Cancer Through the Rac1/PAK1-LIMK1-Cofilin1 Signaling Pathway
Q36963000Diallyl disulfide suppresses epithelial-mesenchymal transition, invasion and proliferation by downregulation of LIMK1 in gastric cancer
Q90087899Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion
Q47427215Ganoderma lucidum polysaccharide inhibits prostate cancer cell migration via the protein arginine methyltransferase 6 signaling pathway
Q52674354Glyoxalase 1 sustains the metastatic phenotype of prostate cancer cells via EMT control.
Q88947003Isoform-specific effects of transforming growth factor β on endothelial-to-mesenchymal transition
Q36957793Liposome-mediated delivery of the p21 activated kinase-1 (PAK-1) inhibitor IPA-3 limits prostate tumor growth in vivo
Q64119982MicroRNA-506 inhibits tumor growth and metastasis in nasopharyngeal carcinoma through the inactivation of the Wnt/β-catenin signaling pathway by down-regulating LHX2
Q38810246MicroRNA-663 suppresses cell invasion and migration by targeting transforming growth factor beta 1 in papillary thyroid carcinoma
Q58732411Modulation in the microRNA repertoire is responsible for the stage-specific effects of Akt suppression on murine neuroendocrine prostate cancer
Q99630289P21-Activated Kinase 1: Emerging biological functions and potential therapeutic targets in Cancer
Q28551296P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate
Q91886070PAK1 promotes proliferation, migration and invasion of hepatocellular carcinoma by facilitating EMT via directly up-regulating Snail
Q36031247Potential role of p21 Activated Kinase 1 (PAK1) in the invasion and motility of oral cancer cells
Q52622319Regulating Cdc42 and Its Signaling Pathways in Cancer: Small Molecules and MicroRNA as New Treatment Candidates.
Q99551806Sterically stabilized liposomes targeting P21 (RAC1) activated kinase-1 and secreted phospholipase A2 suppress prostate cancer growth and metastasis
Q50590583Suppression of Akt1-β-catenin pathway in advanced prostate cancer promotes TGFβ1-mediated epithelial to mesenchymal transition and metastasis.
Q38904873Synergistic immunologic targets for the treatment of prostate cancer
Q48199906TRAF6 regulates tumour metastasis through EMT and CSC phenotypes in head and neck squamous cell carcinoma.
Q64054193Targeting p21-activated kinase 1 inhibits growth and metastasis via Raf1/MEK1/ERK signaling in esophageal squamous cell carcinoma cells
Q50082534The concomitant apoptosis and EMT underlie the fundamental functions of TGF-β.
Q54977610The p21-activated kinase 4-Slug transcription factor axis promotes epithelial-mesenchymal transition and worsens prognosis in prostate cancer.
Q38846822The role of small GTPases of the Rho/Rac family in TGF-β-induced EMT and cell motility in cancer
Q57810885Unfractionated and Low Molecular Weight Heparin Reduce Platelet Induced Epithelial-Mesenchymal Transition in Pancreatic and Prostate Cancer Cells

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